Significantly, disabling both anti-apoptotic proteins, Bcl - 2 and Bcl - xL, in conjunction with Mcl - 1, caused profound cell death of leukemia
cells in the test tube as well as in animal models of AML.
Now researchers have found a way to kill tumor
cells in test tubes without inflicting any collateral damage on healthy cells.
In 2010, Gordon's team demonstrated they could reverse an asthmatic response in human
cells in a test tube.
Numerous small studies show a reduction in depression and fatigue in cancer patients who received Reiki, and a rigorously controlled study in the Journal of Orthopaedic Research showed that
cells in test tubes treated by Reiki practitioners grew better than those in an untreated control group.
And in a recent University of Michigan study, a red wine compound helped kill ovarian cancer
cells in a test tube.
Since these experiments were only performed on cancer
cells in test tubes, the researchers took the next step and ran tests on breast cancer tumors in live mice.
Not exact matches
Researchers at Tufts Medical School noticed that cancer
cells being grown
in the lab multiplied more quickly
in polyester
test tubes than
in glass.
The audience roars with laughter as Polish tells how he initiated select new members into the
cell biology lab he worked
in after college with strategically placed miniature dry - ice bombs fabricated from plastic Eppendorf
test tubes.
Further experiments
in test tubes showed which portion of the sugar molecule the liver
cells were noticing.
Stahelin and co-investigator Smita Soni, a postdoctoral researcher at the Indiana University School of Medicine, found that VP40 is able to assemble
in vitro (i.e.,
in a
test tube), without any human
cells present and mediate formation of virus - like particles when the human lipid phosphatidylserine is found
in solution with VP40, but not other control lipids.
To start, she used a cotton swab to get a sample of
cells from her cheek, boiled them
in a
test tube in her kitchen to free the DNA, then added primers, nucleic acids that mark the part of the sequence.
Smider and colleagues took serum — blood with the
cells removed, leaving antibodies behind — from four immunized cows and
tested it against different types of HIV virus
in a
test tube.
Test -
tube experiments showed that BMAA can kill motor nerve
cells in the spinal cord, the very ones destroyed by ALS.
In further
test tube experiments, the researchers treated the immortalized white blood
cells with both chemical and genetic blockers, called small interfering RNA (siRNA), designed to render either p70S6K or GRB10 nonfunctional.
Living
cells have been doing this for billions of years, and researchers have done it
in test tubes for decades.
In test tubes, this gene caused the
cells to produce extra amounts of a chaperone molecule that ordinarily helps a
cell recognize misfolded proteins.
To determine if Sup35 could change shape on its own or if it needed help from other molecules
in the
cell, the team studied the purified protein
in the
test tube.
De Lange cautions that they still need to demonstrate that what they see
in their
test tube studies occurs
in living
cells.
To see if the same chain of events happens
in rheumatoid arthritis, Smith's team
tested whether various kinds of fibroblasts would spur T
cell migration
in test tubes.
While most research studies begin
in test tubes,
cells grown
in the laboratory and animal models before moving to humans, the opposite is true here.
«The chemistry of
cells, unlike more traditional chemistry
in test tubes, is highly dependent on where a chemical reaction is occurring,» said Christine Payne, an associate professor
in the Georgia Tech School of Chemistry and Biochemistry and one of the paper's senior authors.
The placebo - controlled trial
in nearly 9500 women
tested a gel called PRO 2000, a so - called polyanion that prevented the AIDS virus from entering human
cells in test -
tube and monkey studies.
Using
in vitro, or
test tube, experiments, the researchers applied these chemicals to human cancer
cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.
But fetal tissue is scarce, and research
in the past several years suggests that stem
cells, which can be mass produced
in a
test tube, can also replace damaged brain tissue.
In test - tube experiments with hamster cells, the DNA vaccine created mRNA that both copied itself like it would in the alphavirus and produced antige
In test -
tube experiments with hamster
cells, the DNA vaccine created mRNA that both copied itself like it would
in the alphavirus and produced antige
in the alphavirus and produced antigen.
The researchers note that this study of digestion
in the
test tube is limited by not including the roles of gut
cells, which absorb and secrete metabolites as well.
By combining different fractions
in a trial - and - error fashion with the known NER proteins, Wood's team eventually identified the simplest mixture that would repair DNA
in the
test tube (
Cell, vol 80, p 859).
Other than
in previous publications, optical rogue waves
in this system are clearly ruled by atmospheric turbulence
in a gas
cell, effectively enabling the observation of a storm
in a
test tube.
According to McCague, «the rarity of human prostate cancer
cell cultures makes studying tamandron's potential difficult
in the
test tube.»
Applying a new method that is used mainly
in stem -
cell research and regenerative medicine, researchers from the Technical University of Munich have now devised a robust intestinal model for molecular research into incretin release
in a
test tube (
in vitro).
Researchers at the
Cells - in - Motion Cluster of Excellence at the University of Münster (Germany) have now developed a method enabling them to better evaluate and study the activity of inflammatory cells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organ
Cells -
in - Motion Cluster of Excellence at the University of Münster (Germany) have now developed a method enabling them to better evaluate and study the activity of inflammatory
cells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organ
cells in mice: they have succeeded
in genetically modifying precursors of immune
cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organ
cells, then increasing their numbers
in a
test tube and finally tracking them spatially and temporally
in living organisms.
«A change that makes a slightly less effective protein
in the
test tube can turn into a completely fatal mutation
in the
cell.
They used immortalized myeloid precursor
cells — so - called ERHoxb8
cells — which multiply almost endlessly
in a
test tube and, under certain conditions, can develop into immune
cells.
Their idea emerged from
test -
tube experiments that Munn did years ago, when he showed that some macrophages could stop T
cells in their tracks by starving them of a building block called tryptophan.
A series of experiments showed that SW033291 could inactivate 15 - PGDH
in a
test tube and inside a
cell, and, most importantly, when injected into animal models.
In test -
tube experiments, WS
cells are much more susceptible than normal to harm from a compound that is toxic to DNA.
But that was achieved
in test tubes, not inside living
cells.
For one, Brca1 might behave differently when floating free
in a
test tube than
in the
cell, where it's only been observed bound to other proteins.
Scientists will have to wait a while to find out whether
cells that live longer
in a
test tube will translate into longer lived animals: Cows can live about 20 years.
The researchers have demonstrated that
in test tubes a particular chemical, called CAI - 1, can induce deadly cholera
cells to turn off their virulence genes.
In test tube experiments, they linked virus fragments to human
cell proteins; adding this complex to the T
cells provoked them to fight the virus.
Using genetic techniques, the Imperial team knocked out the Hhat function
in pancreatic cancer
cells and, as they hoped, the cancer
cells showed substantially reduced growth and ability to spread
in a
test -
tube assay.
The
test tube finding, reported
in the current
Cell, could help explain the formation of prions — the tangled proteins that are implicated
in mad cow disease and several human brain disorders — and eventually may lead to a way to smooth out these rogue proteins.
«One of the unique features of µSCALE is that it allows researchers to rapidly isolate a single desired
cell from hundreds of thousands of other
cells,» said Bob Chen, a doctoral student
in Cochran's lab who wrote the software to examine and detect signs of interesting protein activity within the
test tubes.
Next,
in a laboratory
test -
tube experiment they found that mixing serum from women with classic or atypical HELLP together with a monoclonal antibody the blocks complement, resulted
in a significant decrease
in the killing of
cells in the modified Ham
test — from about a 34 % kill rate down to a 5 % kill rate, the amount seen
in healthy individuals.
In test tube studies and experiments with
cells, the researchers found that the TIA1 mutation causes the protein to become more «sticky,» delaying the normal disassembly of stress granules, trapping TDP - 43.
It can be made
in a biodegradable ink form, enabling the researchers to 3D print it into structures that encourage cartilage
cells in the knee to form and grow — a process that they have demonstrated
in test tubes.
In the
test tube, the nanogenerators killed leukaemia, lymphoma, breast, ovarian, neuroblastoma, and prostate human cancer
cells.
In their study Loeken and her group, including Yichao Wu, Marta Viana, and Shoba Thirumangalathu, used mice and cell lines to test their hypothesis that AMPK might be stimulated in the embryo and that stimulation of AMPK was responsible for blocking Pax3 expression and causing neural tube defects in response to high glucos
In their study Loeken and her group, including Yichao Wu, Marta Viana, and Shoba Thirumangalathu, used mice and
cell lines to
test their hypothesis that AMPK might be stimulated
in the embryo and that stimulation of AMPK was responsible for blocking Pax3 expression and causing neural tube defects in response to high glucos
in the embryo and that stimulation of AMPK was responsible for blocking Pax3 expression and causing neural
tube defects
in response to high glucos
in response to high glucose.
Because scientists could use the new stem
cells to make any tissue
in a
test tube, they might have an easier time studying certain diseases and treatments.