Identifying cancer stem cells, the small number of
cells in a tumor believed to fuel its growth and spread
Not exact matches
Although changes
in treatment methodology still have to be studied, Dr. Cripe
believes it may be that the timing of various treatments is what matters, and that perhaps initially suppressing immunity could allow the virus to infect a large number of
tumor cells before relieving the immunosuppression to allow the body's own T
cells to fight off the
tumor.
«We
believe the
cells lacking myoferlin are made softer
in the
tumor so they can't physically detach away.
The study, which appears August 3
in the peer - reviewed journal Nature Communications, showed that pairing the chemotherapy with an experimental drug eliminates the deadly population of
cells believed to be responsible for repopulating the
tumor.
Researchers
believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient
tumor tissues instead of
cell lines grown
in the laboratory.
Cancer biologists once
believed that all
cells in a
tumor were pretty much the same.
It is generally
believed that a series of mutations
in multiple genes are needed for cancer
cells to become metastatic; however, recent cancer stem
cell theory, which still remains as a hypothesis, predicts that metastatic
tumor cells are, by definition, cancer stem
cells and that these
cells may exist
in tumor mass even at an early stage.
LA JOLLA, CA — Scientists have long
believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain
tumor, begins
in glial
cells that make up supportive tissue
in the brain...
Although we
believe our approaches have broad potential across multiple therapeutic areas, we are focused
in oncology and have engineered our technologies to activate the immune system's natural ability to create
tumor - specific cytotoxic T
cells, or CTLs, to fight cancer.
Frouws» team
believe the drug may boost the immune system's ability to detect and destroy circulating
tumor cells in the blood.
Dr. Zihai Li, of the University of Connecticut Stem
Cell Institute, said
in a news release that by immunizing the host with stem
cells, the researchers were are able to «fool» the immune system to
believe that cancer
cells are present and thus to initiate a
tumor - combating immune program.