Sentences with phrase «cells in our immune system called»

CD4 CD8 Ratio Panel (Immune System Analysis)-- We have cells in our immune system called «helper cells» that help our white blood cells attack foreign innovators.

Not exact matches

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

Tesaro has a coveted position as a leader in the so - called immuno - oncology sector, which harnesses the body's own immune system to combat cancer cells.

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

Allison's seminal work focuses on a protein called CTLA - 4, which reins in T - cell activation in the immune system.

Dr. Cripe and his colleagues at The Ohio State University, the University of Pittsburgh School of Medicine and Cincinnati Children's Hospital Medical Center tested how well the oncolytic viral therapy — a cancer - killing form of the herpes simplex virus, called oHSV — infected and killed tumor cells in mice with and without a healthy immune system.

Others include transplanting so - called Schwann cells from peripheral nerves, using growth factors to stimulate nerve growth, and boosting the immune system in the damaged area (New Scientist magazine, 14 August 1999, p 36).

In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipIn a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tips.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

And researchers must figure out how to build in some core features: the necessary blood vessels, immune - system cells called microglia and connections from other brain regions, such as the thalamus and cerebellum.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

«We have immune cells called T - cells that are really good at killing off cancer cells, but there is an inhibition system in place to prevent autoimmunity,» said the study's senior author Maureen Su, MD, UNC Lineberger member and associate professor in the UNC School of Medicine Division of Pediatric Endocrinology.

And the key to vaccine success is that, afterward, the immune system starts to create fast - response infection fighters called memory cells that will circulate throughout the body and be able to recognize (and fend off) that same pathogen in the future.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body, such as bacteria, viruses or foreign cells.

One promising strategy in the fight against cancer is to use the body's own immune system to remove tumor cells, but due to a phenomenon called immune tolerance, the immune system has a difficult time identifying which cells to attack.

But mounting evidence implicates the immune system in the overproduction of cell - signalling molecules called cytokines, which stimulate skin cells called keratinocytes to express genes that maintain an inflammatory microenvironment.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

Cells in the innate immune system respond immediately by secreting inflammatory factors called cytokines to stop the spread of infection.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

Previous studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part of the intrinsic immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

When susceptible people come into contact with flakes of cat skin called dander, T cells in their immune systems set off a chemical chain reaction that produces the familiar symptoms of allergy, including sneezing, runny noses, itching and asthma.

Looking for immune abnormalities throughout the lifespan of the mice, the group found that most immune system components stayed the same in number, but a type of brain - resident immune cells called microglia that are known first responders to infection begin to divide and change early in the disease.

One drug, Protolin, contains bacterial components that rev up immune - system cells in the brain, called microglia, to chew through the beta - amyloid.

In healthy individuals, immune cells produce proteins called antibodies that attack foreign invaders to destroy them and clear them out of the system.

Johannes Scheid, a student in Nussenzweig's lab, isolated it several years ago from an HIV - infected patient whose immune system had an exceptional ability to neutralize HIV in the blood by preventing the virus from infecting and destroying a specific type of immune cells, called CD4 cells, in patients.

Shortly after infection, HIV levels skyrocket, but then the immune system and other antiviral factors produced by cells drive down the amount of virus in the blood — the so - called viral load — and establish a «set point.»

Cells of the immune system, called lymphocytes, play an important role in fighting infection and eliminating cancer cells from the Cells of the immune system, called lymphocytes, play an important role in fighting infection and eliminating cancer cells from the cells from the body.

Researchers at St. Jude Children's Research Hospital have discovered the mechanism by which immune cells called regulatory T cells keep themselves intact and functional during their demanding task of holding the immune system in check.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T - cells that are tailored to the molecular structure of that invader.

This makes it impossible for sugars on the surface of immune system cells called T cells to attach in multiple spots at once and trigger inflammation.

The findings have implications for the design of cancer vaccines and what are called adoptive T cell therapies; when T cells are collected from a patient and grown in the laboratory, increasing in number before they are given back to the patient to help the immune system fight disease.

They fused mouse B cells — antibody - producing cells of the immune system — with human myeloma (also known as B cell cancer) cell lines in a new technique called hybridoma technology.

Another technique - one used by the herpes simplex virus which causes cold sores - is to hide from the immune system in nerve cells called neurones.

In the immune system, T helper cells help immune cells recognize and fight toxins by secreting a protein called interleukin 9 (IL - 9).

For HIV to develop into full - blown AIDS, the virus must deplete a subset of immune cells called CD4 + T cells, disabling an infected person's adaptive immune system in the process.

Specialized glial cells - called «microglia» - serve as a resident immune system cells in the brain, activating in response to damage.

In the rare, life - threatening disease called paroxysmal nocturnal hemoglobinuria (PNH), patients are stricken with chronic anemia and blood clots, when the oldest part of the immune system — known as complement — turns against its own red blood cells, or erythrocytes.

In their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodieIn their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodiein the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodies.

Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and immune cell differentiation, they tested the drugs on a mouse model for uveitis, an incurable eye condition in which the immune system mistakenly attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).

In a paper published online Aug. 31, by Nature Medicine, researchers report that using a monoclonal antibody called anti-CD47, which blocks the «don't - eat - me» signal on malignant cells, to treat mice with an intact immune system provides a much more lifelike way to study and develop an immune - based cancer therapy.

Penn State College of Medicine researchers homed in on the role of a particular cytokine — a cell - signaling protein — called interferon gamma, that is involved in the immune system.

Under normal conditions, so - called checkpoint inhibitor molecules rein in the immune system to ensure that it does not attack the body's own cells, tissues and organs.

For decades, scientists have been seeking a new type of vaccine that activates another player in the immune system called a T cell to fight off infections within different organs.

It is also the first in an emerging class of therapies called «checkpoint blockade,» which enhance the immune system's ability to attack cancer by interfering with immunological checkpoints that slow or stop immune cell activation and proliferation in the presence of tumors or chronic viral infection.

Through his work with large patient groups, he has managed to show that narcolepsy is closely genetically linked to so - called HLA molecules, which play a key part in the immune system by presenting foreign substances to immune cells.