The prize is for discovering «the brain's navigation system»: place cells,
cells in the hippocampus which are active whenever a rat is in a particular place, and grid cells, cells in the entorhinal cortex which are active when the animal is at multiple locations in a grid pattern.
Not exact matches
Specifically, they drew RNA from the
hippocampus,
which is the part of the brain that helps regulate learning and memory, and from leukocytes, white blood
cells that play a key role
in the immune system.
Neurons
in the
hippocampus —
which are affected
in Alzheimer's disease, epilepsy, and other illnesses — were strongly activated, but the neurons above them were not affected, the group reports today
in Cell.
Thus both
in the cerebellum and
hippocampus (previous image), insulin receptors are highly expressed
in cells that form synapses onto MHCI - expressing neurons,
which suggests MHCI and insulin receptors could interact, either directly or indirectly,
in the living brain.
In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
In a new study published
in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
in Science, the laboratory of Sebastian Jessberger, professor
in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
in the Brain Research Institute of the University of Zurich, has shown for the first time the process by
which neural stem
cells divide and newborn neurons integrate
in the adult mouse hippocampu
in the adult mouse
hippocampus.
Glutamate indirectly activates the substantia nigra and ventral tegmental area,
which contain
cells whose axons release dopamine
in the
hippocampus.
Given that lot of those brain
cells seemed to form down
in the area of the
hippocampus,
which is involved with the memory and with learning, it was an easy jump to naturally assume that they must be involved with that
in some way.
Chen and his team began by studying how reactive glial
cells respond to a specific protein, NeuroD1,
which is known to be important
in the formation of nerve
cells in the
hippocampus area of adult brains.
The research team selectively overexpressed a transcription factor, Klf9, only
in older neurons
in mice,
which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the
hippocampus circuitry by two-fold, and activated neural stem
cells.
«We also noticed an accumulation of debris of interneurons — the
cells that serve as a connection between sensory and motor pathways for reflexes —
in the
hippocampus,
which is responsible for memory storage.»
John O'Keefe, along with John Dostrovsky, discovered
in 1971 that the
hippocampus contains special nerve
cells that are involved
in determining an animal's specific location,
which they called place
cells.
The scientists implanted neural stem
cells into the
hippocampus,
which is a brain region involved
in making new memories and connecting them to emotions.
The CBM now forms the core of the new Kavli Institute at Trondheim,
which was inaugurated
in August 2007 and where research continues on grid
cells, as well as areas such as understanding the role of the
hippocampus in shaping memory.
Dr. O'Keefe's research identified neurons
in the
hippocampus, called place
cells,
which respond selectively to an animal's location.
As its name implies, FTD is a fatal disease that destroys
cells, or neurons, that comprise the frontal and temporal lobes of the brain — as opposed to Alzheimer's
which mainly affects brain's memory centers
in the
hippocampus.
Studies
in rats have shown that physical exercise boosts BDNF (brain - derived neurotrophic factor — a molecule that promotes the growth and survival of brain
cells) levels
in the
hippocampus,
which is a brain structure crucial for learning and memory formation.
Develops new nerve
cells from the stem
cells (blank
cells)
in the
hippocampus,
which is the part of the brain related to memory and learning.
Cortisol has been shown to damage and kill
cells in the
hippocampus,
which is the area of the brain responsible for episodic memory.
Cortisol overproduction has been shown to shrink nerve
cells in the
hippocampus and stop the formation of new
hippocampus neurons,
which can cause aging and memory problems.
Stress - activated cortisol bombards the memory center, killing nerve
cells in the
hippocampus, and attacks the immune system,
which often causes depression and anxiety.