Scientists use cell reprogramming techniques to produce
cells in the lab so that they can study diseases.
Not exact matches
So why is it that with all of our science and technology we are unable to create even the simplest
cell in the
lab under the perfect conditions?
In 2015, she and colleagues in Church's lab used CRISPR to eliminate from pig cells 62 genes so potentially dangerous their very existence nixed previous efforts to turn pigs into organ donor
In 2015, she and colleagues
in Church's lab used CRISPR to eliminate from pig cells 62 genes so potentially dangerous their very existence nixed previous efforts to turn pigs into organ donor
in Church's
lab used CRISPR to eliminate from pig
cells 62 genes
so potentially dangerous their very existence nixed previous efforts to turn pigs into organ donors.
So far, researchers have mostly turned on genes with CRISPRa
in cells growing
in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved
in the new study.
For the past several years, researchers have been modifying T
cells so they can attack leukemia, but the
cells must be painstakingly isolated from the patients themselves and grown
in a
lab.
So far Kajander and his colleagues have found the nanobacteria
in cattle blood,
in 80 % of samples of commercial cow serum
in which mammalian
cells are grown
in the
lab, and
in the blood of nearly 6 % of more than 1000 Finnish adults tested.
So when biologists
in Catharina Svanborg's
lab saw mothers» milk kill cancer
cells, they knew they were onto something big.
So Welham's team set out to engineer vocal fold mucosae
in the
lab using the two main
cell types that make up the tissue — connective fibroblasts, which form the main body, and epithelial
cells, which line the surface.
Scientists want to be able to clone early human embryos, using
cells from patients with various diseases,
so they can study the diseases
in the
lab and develop new treatments for them.
«Bone
cells aren't solely studied
in isolation
in the
lab as both local and systemic factors play an important role
in their function,
so it's important to unpick the multitude of biological factors that can affect their proliferation,» says Dr Pablo Roman - Garcia, a first author from the Wellcome Trust Sanger Institute.
Another is that the transplanted bits of tumor act nothing like cancers
in actual human brains, Fine and colleagues reported
in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem
cells, but tumor stem
cells don't grow well
in the
lab,
so they don't get transplanted into those mouse brains.
«This is why some cancers can be
so difficult to treat with chemotherapy, because the
cells can be
in different states — some sensitive to treatment and some resistant to treatment, all
in the same tumor,» says Sandro Santagata, a former visiting scientist
in the
lab of Whitehead Member Susan Lindquist.
Diego Grassi, PhD, a research associate
in Lasmézas»
lab, made this discovery by labeling the pα - syn * with an antibody
so he could follow it throughout the
cell after it was created.
The microbes rely on oxygen, carbon and other nutrients
in their deep environment to live, but Røy's team found that carbon is
so limited that the
cells respire oxygen 10,000 times slower than bacteria
in lab - grown cultures.
He says, «Cytopathologists spend most of the workday
in the
lab looking at
cell and tissue slides,
so I really relished the opportunity to get out and speak with patients.»
This capability allowed the researchers to maneuver the nanospears
in a
lab dish to modify brain cancer
cells so that they expressed a green fluorescent protein.
So instead of studying the whole animals, he began isolating single nerve
cells from the mole rats and investigating them
in lab dishes to track the molecular basis of the rodent's pain insensitivity.
And because CRISPR works
so well
in cells growing
in a
lab dish, some tests can forgo using animals altogether.
«The blood - brain barrier forms pretty early
in gestation,
so the thyroid hormone, even from the mother, is probably not getting through the barrier and into the brain, likely leading to developmental deficits,» says Shusta, whose group was among the first to develop blood - brain barriers from patient - derived stem
cells in the
lab dish.
The findings —
so far observed only
in cells and minibrains grown
in the
lab — offer a possible explanation for the misshapen heads that are the hallmark of microcephaly, a condition that afflicts some babies infected with Zika.
The latest findings from Sullivan's
lab, published
in the June 5 issue of Journal of
Cell Biology, reveal new aspects of a remarkable mechanism that carries broken chromosomes through the process of cell division so that they can be repaired and function normally in the daughter ce
Cell Biology, reveal new aspects of a remarkable mechanism that carries broken chromosomes through the process of
cell division so that they can be repaired and function normally in the daughter ce
cell division
so that they can be repaired and function normally
in the daughter
cells.
Anyone who does, say, research
in my
lab isolating
cells and isolating DNA and sequencing them, they can continue that work
in some other laboratory because the laboratories need technician [s],
so someone can do a part - time job while still taking course [s].
Update:
In an e-mail, a spokesman for Veridex said the collaboration with Mass General is «is just beginning,» so there are «no details about what this future system will look like,» except that it will be small enough to sit on a lab bench and will be able to zero in on the biology of rare cell
In an e-mail, a spokesman for Veridex said the collaboration with Mass General is «is just beginning,»
so there are «no details about what this future system will look like,» except that it will be small enough to sit on a
lab bench and will be able to zero
in on the biology of rare cell
in on the biology of rare
cells.
In their earlier work, the Halle
lab already proved that the bacteria introduce numerous harmful proteins,
so - called effectors, into plant
cells via a specialised secretion system which works like a molecular syringe.
Stem
cell technology has advanced
so much that scientists can grow miniature versions of human brains — called organoids, or mini-brains if you want to be cute about it —
in the
lab, but medical ethicists are concerned about recent developments
in this field involving the growth of these tiny brains
in other animals.
When researchers express interest
in obtaining a certain knockout mouse line, the repositories will send them live mice, frozen embryos, sperm, and / or ES
cells,
so they can study the mice
in their own
labs.
Embryonic stem
cells — the subject of
so much controversy (witness the new ruling blocking their use)-- were first cultured
in the
lab a little more than a decade ago;
in 2006, there was another breakthrough when adult
cells were coaxed into becoming induced pluripotent stem
cells.
When Walter arrived
in Blobel's
lab as a fresh - faced apprentice, Blobel and his colleagues had limned the outlines of the
so - called signal hypothesis, which purported to explain how proteins, which are made
in cellular machines called ribosomes, find their pre-destined locations within
cells.
So far our work has been spread across
Labs at the Centre of Bacteria
Cell Biology (at Newcastle University), Northumbria University and Civil Engineering as well as the workshops
in Architecture at Newcastle University.
«This mouse strain is great model for this research because they are otherwise healthy and normal, including
in their vision,
so it allows us to conduct studies focused on
cell integration,» said the publication's lead author, Jie Zhu, PhD, a postdoctoral researcher who started
in Lamba's
lab three years ago.
They are popular
in the
lab because they are single
cells —
so they are considerably easier to study than multi-celled organisms — but they still have the complex internal organization common to plants, animals, and fungi.
The blood is efficiently separated
so that mononuclear white blood
cells and peripheral blood stem
cells can be transferred to a collection bag which will be transferred to the
lab and frozen for later use
in adult stem
cell therapy.
«The problem is that brain
cells from actual people don't survive well
in a dish,
so we need to engineer human
cells in the
lab,» explained Gan, senior investigator at the Gladstone Institutes.
And to do
so, Ottersbach and her team are trying to understand how the disease might begin, even before birth, by looking at
cells in the
lab as well as young mice with the disease.
So Dupont sent some of Melvin's skin
cells off to the
lab in South Korea.
If you have a female cat that is not spayed, your veterinarian may also do a vaginal cytology, a
lab analysis of the
cells in the vagina
so that the stage of estrus (heat) she is
in can be determined.
And meanwhile, university researchers can and do work on embryonic stem
cells — just
so long as they don't use federal funds (which makes for some complicated partitioning of
lab equipment
in many a US university department).
I was a physiologist by training and education, but the new
lab was a stem
cell / molecular biology research
lab,
so I was trained
in th...