Sentences with phrase «cells in the laboratory with»

Dr. Bauman and her colleagues treated human head and neck cancer cells in the laboratory with varying doses of sulforaphane and a control, and compared them to normal, healthy cells that line the throat and mouth.

Not exact matches

By encapsulating the follicles in the alginate and providing the growing cells with precise mixtures of nutrients and hormones, researchers at the ONPRC and elsewhere have been able to mimic the ovary's natural structure in the laboratory.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer development.

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

The researchers instructed 146 college students to sit in an austere laboratory for up to 15 minutes without cell phones, books or other distractions, entertaining themselves with only their thoughts.

We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.

They simulated pressures that were beyond the highest possible pressures attainable in the laboratory with instruments called diamond anvil cells.

Beginning in the 1970s, physicians learned how to harvest skin stem cells from a patient with extensive burn wounds, grow them in the laboratory, then apply the lab - grown tissue to close and protect a patient's wounds.

When RCGD 423 was applied to joint cartilage cells in the laboratory, the cells proliferated more and died less, and when injected into the knees of rats with damaged cartilage, the animals could more effectively heal their injuries.

Research for the study was conducted by first co-authors Dr. Ranit Kedmi and Nuphar Veiga and colleagues at Prof. Peer's TAU Laboratory, in collaboration with Prof. Itai Benhar of TAU's School of Molecular Cell Biology and Biotechnology, Dr. Michael Harlev of TAU's Veterinary Service Center, Dr. Mark Belkhe of Integrated DNA Technologies (IDT) and Prof. Judy Lieberman of Boston Chidren's Hospital and Harvard Medical School.

Scores of laboratories at universities and in private industry are uncovering how to use these cells, which transform into neurons, astrocytes (the cells that regulate transmission of electrical impulses in the brain) and oligodendrocytes (which insulate nerve fibers with a fatty coating).

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

The prize will be equally split between biophysicist Venkatraman Ramakrishnan of the MRC Laboratory of Molecular Biology in Cambridge in England, biochemist Thomas Steitz of Yale University and molecular biologist Ada Yonath of the Weizmann Institute of Science in Rehovot, Israel, for their work in using x-ray crystallography to get a precise, atomic - scale map of the ribosome — the protein - making machine in all cells with nuclei that makes life possible.

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.

Results suggest that while isotretinoin was associated with a change in the average value of some laboratory tests (white blood cell count and hepatic and lipid panels), the average change across a patient group did not meet the criteria for high - risk and the proportion of patients with laboratory abnormalities was low, the authors report.

Isoflavones have been shown to slow the growth of breast cancer cells in laboratory studies, and epidemiological analyses in East Asian women with breast cancer found links between higher isoflavone intake and reduced mortality.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

In conjunction with the laboratory of Matthew J. Evans, PhD, from the Department of Microbiology at Icahn School of Medicine at Mount Sinai, investigators demonstrated the functionality of the liver cells generated from the progenitors, as the liver cells can be infected by the hepatitis C virus, a property restricted to liver cells exclusively.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

Health: Combined Optical and Magnetic Resonance Microscope - «Studying cells in real time» Dr. Robert Wind, Scientist at Pacific Northwest National Laboratory in Richland, WA helped develop a combined microscope that can study live cells at the same time with two completely different microscopic techniques.

«All the exciting efficiencies and any energy claims that are associated with [perovskite solar cells] should be taken with a grain of salt,» according to Keith Emery, the manager of the National Renewable Energy Laboratory's (NREL) photovoltaic cell and module performance characterisation group in the US.

«Despite the fact that the literature describes only correlation between verbal memory tests and hippocampal cell densities in patients with left hippocampal sclerosis, we found a correlation between right hippocampal cell densities and performance on visual memory tests, including both immediate and delayed recall,» says authors Sandra Mara Comper and Anaclara Prada Jardim, students in the laboratory of Dr. Elza Marcia Yacubian at the Federal University of São Paulo.

So Ke Cheng, Hu Zhang, Jinying Zhang and colleagues wanted to see whether placing stem cells in inexpensive hydrogels with designed tiny pores that are made in the laboratory would work.

When combined with the compound, called ganciclovir, these loaded nanoparticles were 100 percent effective at killing glioma cells grown in laboratory dishes.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

Their approach is to combine the study of cells isolated from TB - infected patients with micro-engineering in 3D in the laboratory to investigate how TB damages the lungs.

In 2005, Rudolf Jaenisch's laboratory at Whitehead reported preliminary success with this strategy, using mouse cells.

Researchers remove these mechanically and, with some luck, can nurture them into an embryonic stem cell line that lives in perpetuity in the laboratory.

In the new paper, Kajimura's team collaborated with the laboratory of Yasushi Ishihama, PhD, of the University of Kyoto, Japan, to search for differences in how white and brown fat cells respond to the cold using a technique called phosphoproteomicIn the new paper, Kajimura's team collaborated with the laboratory of Yasushi Ishihama, PhD, of the University of Kyoto, Japan, to search for differences in how white and brown fat cells respond to the cold using a technique called phosphoproteomicin how white and brown fat cells respond to the cold using a technique called phosphoproteomics.

Indeed, when fat stem cells isolated from healthy obese individuals were exposed to interleukin - 6 in the laboratory, they behaved like those obtained from individuals with risk of diabetes.»

Dieter Egli and Scott Noggle of the New York Stem Cell Foundation Laboratory in New York City and colleagues fused skin cells with unfertilised human eggs.

Bruce Buchholz of the Lawrence Livermore National Laboratory used cellular markers for a study in which he concluded that we're more or less stuck with the number of fat cells we have at about age 20.

When the researchers used gene engineering techniques to knock out DDX3 expression in laboratory - grown cell cultures that highly expressed this protein, cell proliferation was half that of cell cultures with high DDX3 expression.

Greider, a young new investigator at Cold Spring Harbor Laboratory (CSHL) on Long Island, New York, and her collaborator, molecular biologist Calvin Harley of McMaster University in Hamilton, Ontario, had shown 2 years earlier that telomeres shorten with each cell division.

Lives of soldiers and others injured in remote locations could be saved with a cell - free protein synthesis system developed at the Department of Energy's Oak Ridge National Laboratory.

«The results were remarkable, with significant shrinkage in patient - derived tumors,» said Memarzadeh, who also is an associate professor of obstetrics and gynecology and the director of the G.O. Discovery Laboratory at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and associate professor.

«We demonstrated that in the absence of Numb, photoreceptors are unable to send a molecule essential for vision to the correct compartment, which causes the cells to progressively degenerate and ultimately die,» adds Dr. Ramamurthy, who carried out the project in Dr. Cayouette's laboratory in collaboration with Christine Jolicoeur, research assistant.

The study used a well - known line of pancreatic cancer cells (AsPC - 1) in the laboratory and assessed how well this grew when treated with either the chemotherapy drug gemcitabine or different levels of commercially available chokeberry extract alone, and when treated with a combination of gemcitabine and chokeberry extract.

In laboratory experiments, Gefter and his colleagues showed that T cells from allergic people can be made tolerant to the complete allergen if they are presented beforehand with isolated epitopes.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humanIn research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humanin Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humCell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humcell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humanin laboratory mice with liver and heart disease that mimicked these conditions in humanin humans.

The iPSCs were then reprogrammed to become neurons in collaboration with the laboratory of Larry Goldstein, PhD, director of the UC San Diego Sanford Stem Cell Clinical Center.

In experiments on dog cancer cells in the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitIn experiments on dog cancer cells in the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitin the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitin fact, bind to canine cancer cells with greater specificity.

To find out more about how RNAi works, a team led by biochemist Scott Hammond of Cold Spring Harbor Laboratory in New York picked double - stranded RNA known to interfere with a gene involved in promoting cell division.

Moreover, they suggest, laboratory experiments with drugs designed to clear up these cellular «traffic jams» restored normal transport in and out of the nucleus and saved the cells.

In May 2001, the U.S. Justice Department charged two Japanese - born scientists with conspiring to «benefit a foreign government» by stealing trade secrets in the form of cell lines and DNA samples from a laboratory at the Cleveland Clinic Foundation in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274In May 2001, the U.S. Justice Department charged two Japanese - born scientists with conspiring to «benefit a foreign government» by stealing trade secrets in the form of cell lines and DNA samples from a laboratory at the Cleveland Clinic Foundation in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274in the form of cell lines and DNA samples from a laboratory at the Cleveland Clinic Foundation in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274).

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

«The researchers now plan to team up with other world - leading experts in cancer signalling based in Manchester including Professor Nic Jones, Director of MCRC and Cancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental stress.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.