Sentences with phrase «cells in the tumor environment»

Identifying and exploiting a novel mechanism that may disrupt this process by inhibiting the interactions between tumor cells and cells in the tumor environment will speed clinical investigations, and ultimately lead to improved outcomes for dogs with this devastating disease.

Not exact matches

When tumor cells are present in an environment that lacks oxygen and nutrients, they receive a signal that it is time for the cells to move to a different part of the body.

These might make a cell hardier in a foreign environment — say, when a breast cell relocates to bone — or more able to escape the primary tumor and survive while rushed through the bloodstream.

Researchers at the University of Southampton have engineered cells with a «built - in genetic circuit» that produces a molecule that inhibits the ability of tumors to survive and grow in their low oxygen environment.

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia AgostiniIn this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostiniin the tumor,» says Patrizia Agostinis.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

The new «tumor in a dish» method begins by taking the cancerous tissue removed during surgery or biopsy, cutting it up into small pieces and putting them in a special collagen gel that maintains them as «organoids» that retain the three - dimensional structure of the original tumor and include supporting cells from the tumor's environment.

«We need to get the [tumor] stem cells to grow in an environment much more like a patient's brain,» he said.

Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.

Cancer stem cells are not limited to the tumor itself and they are able to engage again in healthy environment and stimulate the disease.

They found that cancer stem cells seemed to appear in the highest numbers along the edges of the engineered tumor environments, particularly where there were corners and convex curves.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeareIn the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appearein the tumor the stem cells appeared.

Beyond the fundamental science of finding and understanding these cancer - spreading cells, he also sees engineered tumor environments as having therapeutic applications in personalized medicine.

«The antibody - driven innate response creates an environment such that when the T cells come in, they can kill the tumor.

«This trial showed that there is a need to target additional antigens in glioblastoma, as well as overcome the immunosuppressive environment that the CAR T cells encountered in the tumor,» Maus said.

They found that, by using math models to understand the complex dynamics within cancers, they could use small changes in the environment to promote the growth of cells that are less aggressive and thereby decrease tumor growth.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

While previous research had shown some effectiveness of this molecule in a mouse model of ovarian cancer, that benefit was limited by the immunosuppressive environment within tumors, particularly the presence of regulatory T cells (Tregs).

«Our study pinpoints a novel way in which tumor cells not only survive but actually continue to divide in spite of a low oxygen environment.

The system can help scientists determine more about how a cell reacts to its immediate environment, Bissell says, and how that process goes wrong in growing or spreading tumors, in which cells lose their ability to read signals from their environment that would prevent them from dividing.

The discovery sheds light on the tiny «environments» that stem cells occupy in animal bodies and may help explain how stem cells in tumors replenish themselves, the researchers report in the May 8 issue of the journal Cell Reports.

Zhang's laboratory now seeks to understand the mechanisms of the tissue - environment influence, opening the possibility that the environment could be altered in a way that fights cancer by preventing tumor cell growth.

«So a cell that rewires its metabolism early on to scarf up nutrients from the environment is more likely to do what the tyrosine kinase pathway sets in motion; it's more likely to have all the things it needs to become a tumor.»

The team is also studying changes in the tumor microenvironment — the cells that support cancerous cells in a tumor — to see if there are changes and the environment is more or less «inhabitable» following treatment.

They looked for correlations between specific mutations in the tumor cells and the composition of the tumor microbiome — the types of bacteria present in the tumor's immediate environment and their relative abundance — and found relationships between the two.

While the cancer normally excludes immune T - cells, the Evans lab discovered that modified vitamin D reprograms the cancer environment in a way that may allow the Merck drug Keytruda ® to invade and destroy the tumor.

Hunter's breakthrough, which set the story in motion, was a product of basic research on a chicken RNA tumor virus: the 1979 discovery of the first tyrosine kinase paved the way for our understanding of how cells perceive their environment and respond appropriately to growth signals.

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For example, most of these tumors make growth factors that they need to survive, or they «coerce» cells in their environment to do this for them.