Sentences with phrase «cells in tissue samples»

Twenty - four hours after the injection, the researchers saw large numbers of immune system white blood cells in tissue samples of the rodent brains near the site of injury of those mice injected with the cytokine IL - 1b, but not in the brain tissue of the control group of mice.

At the heart of mass spectrometry is the ability to precisely measure tiny samples of substances such as chemicals in soil and water or cancer cells in a tissue sample.

Not exact matches

But scientists published in Cell Reports that they've discovered a way to regenerate those cells in mouse, primate and human tissue samples.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

«When we analyzed tissue samples in the lab, we found that exposing white fat to macrophage cells from the immune system inhibited the transformation.»

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

These triple - mutant H7 hemagglutinins also successfully latched onto cells in samples of human trachea tissue.

In this study, rather than studying one iPS cell line, the researchers derived and sequenced 10 iPS cell clones from each patient tissue sample to get a better understanding of mitochondrial DNA mutation rates.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

Looking at just one or two molecules in cell or tissue samples is fairly straightforward.

Scientists aim to freeze a sample of the boys» testicular tissue so that when they reach adulthood, spermatogonial stem cells (SSCs) found in the tissue can be reproduced and transplanted back into the patients.

«Our study addressed an important safety issue — whether cancer cells that might be present in testicular tissue samples can survive the process to replicate the sperm - producing stem cells,» said lead author Hooman Sadri - Ardekani, M.D., Ph.D., an instructor in urology and regenerative medicine at Wake Forest Baptist Medical Center.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The new method has numerous advantages: researchers can sample individual cells of a tissue culture directly in the petri dish.

The scientist tested their set - up using frozen human skin cells, segments of pig heart tissue, and sections of pig arteries in volumes almost 20 times larger than previously attempted samples.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

Imaging techniques that rely on light — such as taking pictures of cells tagged with a «reporter gene» that codes for green fluorescent protein — only work in tissue samples removed from the body.

For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.

Working with the brains of six normal children and seven autistic children ages 2 to 16, most of whom died of drowning, Courchesne has studied neurons under the microscope and even counted the number of neural cells in different tissue samples.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

But locating the cells that contain the 50 - nanometer particles has been like looking for a needle in a haystack, in part because the tissue - dissolving methods used to identify magnetite turn biological samples to mush.

They observed similar results in ART - controlled, HIV - infected patients who had undergone elective abdominal surgery: their SVF samples are positive for HIV DNA, and the researchers could show the presence of infected and virus - producing cells within the patients» adipose tissue and more specifically among adipose CD4 + T cells.

The rate of JAK2 amplification in these tissues was similar to samples obtained after chemotherapy, suggesting that JAK2 plays a supporting role in drug resistance and cancer stem cell - like features.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

At the moment, prenatal diagnosis for a small number of genetic conditions is usually done from fetal cells that doctors capture from fluid in the womb (amniocentesis) or a snippet of placental tissue (chorionic villus sampling).

These steps are intended to crack open the biological material in the sample: from the comparatively massive eukaryotic cells of bat tissue, to simpler gut microbiota, to tiny viral particles.

The research used skin samples from five men to create what are known as induced pluripotent stem cells, which closely resemble embryonic stem cells in their ability to become nearly any tissue in the body.

Almost all peaks (96 %) were observed in at least 2 samples, but most were present in less than half of samples, suggesting a lot of cell / tissue / sample specificity.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

Samples matrixes suitable for metabolomics analyses include in vitro: cell lysate and medium, and in vivo: Plasma, serum, urine, CSF, micro-dialysate and tissues

«Our research is possible thanks to the accessibility of primary tissues at the University of Birmingham, which allows basic research in cells to occur alongside studies that examine patient samples.

The researchers took healthy tissue and tumor samples from mice, and trained the nanoparticle - GFP sensors to recognize the bad cells, and for the GFP to fluoresce in the presence of metastatic tissues.

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

After more than a year of planning, the project had an easy - to - use, online consent form in which MBC patients could agree to share medical records, treatment history and tumor tissue and donate saliva samples (allowing researchers to analyze both their cancerous tumors and noncancerous cells).

The technique is insensitive to the level of mutated cancer cells in the sample, and the information about mutations can be linked directly to the way the tumour cells are growing in the tissue sample.

Previous studies of this type relied on microscopic examination of tissue samples from sacrificed animals, but this new approach allows researchers to watch the life or death of cells in real time.

There are many more glial cells in the brain than neurons, and astrocytes are the most abundant of the glia, so if you take a sample of brain tissue, you're fairly sure to get some astrocytes as part of the bargain.

Just fill up the vat with embryonic stem cell fluid, pop in a tissue sample and set the dial to «gestate.»

Due to the heterogeneous structure of the brain, with many nuclei and cell - types organized in complex networks, it is difficult to achieve a comprehensive overview in a 1 mm tissue sample.

Protein expression is annotated in 76 different normal cell types present in these tissue samples.

In a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyIn a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin the body).

UNISI will provide expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a Cytometric bead assay.

Such stem cells are «immortal» in the lab, meaning there is no need for new cell cultures or re-harvesting from additional tissue samples.