Sentences with phrase «cells increased from»

The p53 activity in the 293 and 293T cells increased from 12 through 24 h after treatment with 10 nM ActD (Fig. 2).

At 48 hours after treatment with 20 μmol / L rapamycin, the percentage of Annexin V — positive cells increased from 18 % to 41 % (A, bottom left).

Not exact matches

The study found an increased risk of cardiac schwannoma, a tumor type that typically originates from cells found in neurons.

With the money from the SBA, the cluster has worked to increase the awareness and adoption of fuel - cell technology, Rinebold says.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The evolutionary sequence from protons, molecules, cells, plants and animals to people would be interpreted as an increase in complexity of experience and degree of self - determination.

Far from being stultified by overcrowding, the cells of individual freedom, in a concerted action growing more powerful as they increase in numbers, will rectify and redress themselves when they begin to move in the direction towards which they are inwardly polarized.

The objects of his study range from a class of molecules that have the basic self - duplicating property of living things, through cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control by impersonal laws of nature.

A number of lab and animal studies have found that healthy organic food may increase antioxidant content, helping to protect cells from damage.

Exposure to smoke increases a child's risk for illness and infection, but the immune - fighting cells in breast milk help protect a baby from those illnesses.

Other essential nutrients in onions are antioxidants that promote cellular structuring, increase immunity, and protect from free radical damage to the cells.

However, despite constant reminders, alarming stastistics from AAA of Western and Central New York show that over the last five years there has been a 50 percent increase in cell...

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

In blood samples from these patients, the researchers found an increase in the percentage of gamma delta T cells, similar to what they observed in mice, which remained stable over years.

The brainlike structures created from cells taken from autistic children showed increased activity in genes that control brain - cell growth and development.

The Chinese government hopes to avoid an auto - driven environmental apocalypse both by mandating increasing fuel efficiency but also by pushing these domestic vehicle manufacturers for homegrown hybrid, electric and fuel - cell vehicles under its «863» program — deriving its name from its launch back in March 1986.

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

Unlike the differential effect on Treg cell proliferation following PD - L1 blockage, the researchers observed an increase in the proliferation of killer T cells from all HIV study groups, regardless of their viral load.

Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.

In addition, compared to mice on a regular diet, brain cells from animals in the olive oil group showed a dramatic increase in nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

In addition, they found that PD - L1 blockade increased virus production in the cell culture from such patients.

But in some cases, the theory goes, leftover antibodies from the first illness can actually help the second infection invade cells, increasing the risk of severe dengue disease.

Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

«Knowing these cells are leading to increased cancer risk may allow us to find drugs to keep mature cells from starting to divide and multiply,» Mills said.

The discovery, based on DNA evidence and reported in the Cell Press journal Current Biology on July 30, increases the overall biodiversity of the Canidae — the group including dogs, wolves, foxes, and jackals — from 35 living species to 36.

Furthermore, when healthy neurons in a dish were treated with serum from the patients and antibodies against leiomodin - 1, they did not survive, but removing the antibodies increased brain cell survival.

They found that a certain protein, known as S100B, is markedly increased in astroglial cells from patients with Down syndrome compared with those from healthy controls.

Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts.

The temporal association — the number of bacteria increased in the blood before the SIV appeared in the blood — led him to believe that the virus first attacks CD4 + T cells that help protect the gut wall from microbial translocation.

The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive immune cells, called type II NKT - TFH, that promote the development of plasma cells.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

Giving the mice antibiotics helped gemcitabine kill tumor cells, increasing the number of tumor cells going through a type of cell death called apoptosis from about 15 percent to 60 percent or more.

MicroRNAs that reduce cholesterol export from cells are encoded in the same genes that increase cholesterol synthesis.

He noted that even the Obama administration's 75 approved stem cell lines (increased from the Bush administration's 21) are not enough for robust research in the field.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

In the study, they reported that a PPMO designed to prevent creation of the AcrA protein significantly increased the efficacy of antibiotics against E. coli in cell models — from two - to 40-fold.

But the increased mental muster did not come from neurons, the lanky nerve cells that swap electrical signals and stimulate muscles.

Increasing the expression of one of the proteins, SIX3, in the insulin - producing cells isolated from younger donors enhanced their ability to respond efficiently to rising glucose levels.

With this technique, the Empa team has again been able to significantly increase the energy conversion efficiency from sunlight into electricity using CIGS thin film solar cells on flexible plastic foils — to a new record level of 20.4 %, representing a marked improvement over the previous record of 18.7 % established by the same team in May 2011.

«Although we found that chemotherapy activated the T cells, the levels of the protein PD - L1 [to which the immune checkpoint molecule PD - 1 binds to disable T cells and prevent them from recognizing and destroying the cancer cells] remained the same or increased.

The paper not only seemed to validate the group's claim a year earlier that it had created a single cell line from a cloned human embryo, but it also reported a huge increase in efficiency for the technique.

Some experts suspect that an excess of TIGR could cause increased eye pressure by gumming up the space between the meshwork cells and blocking the normal outflow of fluid from the eye.

Carpenter told the congressional panel that most of the studies that have shown an increased risk are from Scandinavia, where cell phones have been popular since the early 1990s.

Eventually, she says, it might be possible to use our increased understanding of RFX transcription factor to treat hearing loss, by either protecting hair cells from death or fostering their growth.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

«We have some very encouraging data from an ongoing study that you can modify the status of cells and increase the efficiency of cloning,» he adds.

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.