Sentences with phrase «cells increased only»

We found that, in the allogeneic group, IFN - γ +, IL - 17A +, and IFN - γ / IL -17 A double - positive CD4 + T cells derived from spleen (Fig. 2A, 2B) and MLN (Supplemental Fig. 1A, 1B) increased since the early stage after transplantation compared with the syngeneic group, whereas the IFN - γ — and / or IL - 17A — producing CD8 + T cells increased only at the late stage (Supplemental Fig. 1C, 1D).

Not exact matches

While the mechanisms at play aren't totally understood, he said, young organisms» blood not only contains all sorts of proteins that improve cell function; somehow it also prompts the recipients» body to increase its production of those proteins.

Blakemore argues that a single gene mutation could in fact have been the cause of this increase - for in fact only one extra cell - division step would cause a doubling of brain size.

The BCAA leucine is the only amino acid that helps to stimulate muscle cell DNA to increase muscle protein synthesis.

Your little one weighs almost 10 ounces, which is a major increase in weight since starting out as a single dividing cell, only 18 weeks ago.

These cells are sparse up until 38 weeks, increasing gradually after that time, and increasing 300-fold after labor has begun.7 The relative scarcity of oxytocin receptor sites is one of the main lines of defense for keeping the uterus quiescent throughout the entire preterm period — but it is not the only one.

The research team found that when it increased levels of E-NTPDase2 in tadpole embryos that consisted of only eight cells, they could cause parts of the eye to form not only on the heads of the amphibians, but also in tissues in other parts of their bodies, including their tails.

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

He notes that the increase could be misleading; it's possible, for example, that the drug changes the architecture of cancer cells in the prostate, making them only look worse.

Increasing levels of PUMA only affected stem - like cells that were starting to spread and not the growth of primary tumors.

The paper not only seemed to validate the group's claim a year earlier that it had created a single cell line from a cloned human embryo, but it also reported a huge increase in efficiency for the technique.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

Using iPS cell technology, the scientists found that only cells harboring the FOP gene mutation would respond to Activin - A by significantly increasing their BMP signaling.

They found that when IGF - 1 was added to the cultured blood cells there was increased lithium sensitivity only in the blood cells of those bipolar disorder patients who did not respond to lithium therapy.

However, the current study found that harmine causes only modest increases in c - MYC levels, and no beta cell death.

Dr. Qu said not only did disc height increase, but stem cell transplant also increased disc water content and improved appropriate gene expression.

This cell only responded to higher frequencies, especially at low volume levels; increased volume expanded the cell's frequency range of response.

According to Bolton, 8 - PN showed only a slight increase of metabolism in breast cells, while the other two compounds did not have significant effects in either cell line.

«We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.»

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Albertini's group now suggests not only that these outside cells tell the egg where to locate the polar body — and, therefore, the nucleus and spindle — but also that their plumbing lines soften up the egg cell's rind in the opposite, or vegetal pole, to increase the odds that sperm will penetrate the hemisphere opposite the nucleus.

Not only did increased stress relaxation dramatically increase early osteogenic differentiation but those cells continued to grow as bone cells weeks after their initial differentiation and formed an interconnected mineralized matrix rich in collagen, key structural features of bone.

This protein causes the amount of lactic acid in the cell to increase, which normally only happens at low oxygen levels.

Unlike most biomarkers for cancer, DDX3 mRNA expression only increased slightly in the exposed breast cells, but the corresponding proteins levels were significantly higher.

«Our chip is currently the only device that can potentially capture circulating tumor cells and exosomes directly on the chip, which should increase its ability to detect metastasis.

But if the cells can be fertilized and develop normally, Caplan predicts, they will only increase the concerns of opponents to ES cell research.

Only those possessing SGI1 were found to be more virulent, as measured by a dramatic increase in their ability to invade intestinal cells after exposure to protozoa.

The research team selectively overexpressed a transcription factor, Klf9, only in older neurons in mice, which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the hippocampus circuitry by two-fold, and activated neural stem cells.

Only the precise stimulation of engram cells was able to increase the number of spines and bring about the memory improvement in AD mice.

«Work continues to identify the other factors, including small molecules, necessary to not only promote the maturation and survival of the newly generated hair cells, but also increase their number,» Zuo said.

We observed similar robust increases of intracellular calcium concentrations in response to KCl and ATP in both GFP - expressing (n = 28) and GFP - nonexpressing cells (n = 12), whereas 5 - HT elicited an increase in intracellular calcium only in GFP - expressing cells (KCl: t (40) = 0.98, p = 0.33; ATP t (38) = 1.04, p = 0.30; 5 - HT: t (38) = 5.24, p < 0.0001 Student's t tests; Fig. 4A, B, F).

In the nose, these cells could increase production of proteins that are typically abundant only in the intestines and that are particularly effective against pathogens such as S. aureus.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.

From 1990 to 2010, the efficiency of solar cells only increased 1.3 percent, from converting 25.1 percent of absorbed light to 26.4 percent.

Of note today: non-exclusive breastfeeding increases the risk of HIV transmission via the alteration of gut microbiome / T - cell activation; Fasting altered the gut microbiome in beneficial ways but only in mice previously fed a high fat diet; An investigation into new species of the honey and bumblebee gut commensal genus Gilliamella; Catfish development shapes gut microbial community structure independent of diet; A metagenomic analysis of the skin microbiome of the frog, Craugastor fitzingeri; The microbiome is altered during the bioremediation of herbicide contaminated soil; The impact of urban density on the soil microbiome; A randomized placebo controlled clinical trial of a microbiota based drug for the prevention of Clostridium difficile Infection; and the virome of the Cuatro Ciénegas Basin of Mexico

A full accounting of what is going on under the hood still remains to be accomplished, but the most plausible mechanism appears to be increased stem cell activity, while effects on cancer may involve a more active immune system - though that is only speculative theory at this point.

Whilst the supplements did not affect maximal oxygen uptake or the results of a 20 metre shuttle test, the results showed that markers for the production of new muscle mitochondria — the power supply for cells — increased only in the group without supplements.

That combination — of just three genes, Oct3 / 4, Sox2 and Klf4, plus valproic acid — not only produced iPS cells but also increased the efficiency of the procedure a hundredfold.

This increased the likelihood of obtaining wells containing only single cells and minimized the existence of doublets, which prevent the derivation of a clonal population.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.

This approach not only enables us to get highly pure populations of DA progenitor cells (> 90 %), but it also increases our final yield of transplantable cells > 40 times when compared to previous embryoid body protocols starting with the same number of cells.

Immune aging and dysfunction results in part from there being only a small supply of such new cells, so any method of increasing that supply will probably prove useful.

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MCells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267).

Testing eight different combinations of the corrective tRNAs, each designed with or without the RP import signal, its modified aminoacyl stem, or the MTS, they found that with the inclusion of all three modifications — and only with their inclusion — expression of their constructs induced a substantial increase in mitochondrially - encoded protein synthesis (6 -8-fold) and respiration (~ 2.5-fold) in mutant cybrid cells.

However, the suit went to the Court of Appeals, which reversed the dismissal when it ruled that Sherley and Deisher were harmed by Obama's policy; as they only worked with adult stem cells, theoretically they would have to deal with increased federal funding competition (due to an increase in hESC research).

In cells treated with both anti-Nrf2 siRNA and HPP - 4382, HMOX1 E2 ARE occupancy by Nrf2 was also increased relative to the levels observed in cells treated with anti-Nrf2 siRNA only, but not to the level observed in cells treated with HPP - 4382 without Nrf2 silencing (Figure 5C).

TNF not only initiates a cascade of other chemical messengers but also increases blood - vessel permeability, allowing white blood cells to pass easily out of the capillaries to reach the site of an infection.

Only in the last 10 years, with increasing knowledge of the senescent phenotype and the ability to detect senescent cells in human tissues, have biologists been able to investigate the relationship between cellular senescence and disease.