Sentences with phrase «cells increased with»

The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

Not exact matches

«Generally it is seen with products that increase cell turnover such as retinoid or hydroxy acids,» Dr. Shah said.

With the money from the SBA, the cluster has worked to increase the awareness and adoption of fuel - cell technology, Rinebold says.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

There are a number of competing solar cell technologies (c - Si, perovskite, CIGS, etc), but currently with 80 tonnes of silver necessary to generate one GW of solar power, should solar really become ubiquitous, a steady and increasing demand driver for silver is in place.

«In its 4.6 billion years circling the sun, the Earth has harbored an increasing diversity of life forms: for the last 3.6 billion years, simple cells (prokaryotes); for the last 3.4 billion years, cyanobacteria performing ph - otosynthesis; for the last 2 billion years, complex cells (eukaryotes); for the last 1 billion years, multicellular life; for the last 600 million years, simple animals; for the last 550 million years, bilaterians, animals with a front and a back; for the last 500 million years, fish and proto - amphibians; for the last 475 million years, land plants; for the last 400 million years, insects and seeds; for the last 360 million years, amphibians; for the last 300 million years, reptiles; for the last 200 million years, mammals; for the last 150 million years, birds; for the last 130 million years, flowers; for the last 60 million years, the primates, for the last 20 million years, the family H - ominidae (great apes); for the last 2.5 million years, the genus H - omo (human predecessors); for the last 200,000 years, anatomically modern humans.»

In various experiments with various conditions, scientists have been able to create a wide range of cell - like structures of increasing complexity on the road toward a simple self - replicating organism.

We anticipate some sort of growth toward increased complexity: increasingly larger organic macromolecules, then the convergence of many macromolecules to constitute a simple living system, either as a cell with its protective wall and vital nucleus or as some functional analogue, then the convergence of many cells to form larger organisms.

Planetary life started with the simplest living cells and amoebae - like creatures, yet out of them, through increasing complexity, our own species eventually evolved.

Duly reverential, the panel satisfied itself with simply listing all the research possibilities, including the improvement and increased safety of IVF, the creation of cell lines that might someday be useful for bone marrow transplantation, repair of spinal cord injuries, skin replacement and, naturally, the hint of a greater understanding of cancer.»

The load cell type SLCAD - ST offers extra safety in applications with heavy rollers and increased temperature compensation.

They are also packed with B vitamins that bring energy to your cells and increase the metabolism.

The technique is the same, though — by placing fruit in syrup with gradually increased sugar content, their cell liquid is getting replaced by sugar.

A 2012 study found that consuming maltodextrin increased bacterial adhesion to human intestinal epithelial cells and enhanced E. coli adhesion, which is associated with autoimmune disorders and dybiosis in your gut.

Its a dry oil so it absorbs right away and has high levels of Vitamin A so causes increased cell turn over helping with wrinkles, pigmentation, and acne!

The risk that an athlete with sickle cell trait will suffer exertional sickling is increased by:

In fact, according to researchers Laura Glynn and Curt Sandman, the volume of gray matter (or number of neural cell bodies) increases in the above regions in new mothers and is associated with their positive feelings toward their infants.

White blood cell count increases with vigorous crying, suggesting the body is preparing a survival response.

With an allergic reaction, there is a release of mast cells, which contain heparin and histamine and then follows by an increase in IgE.

Clamping the cord, especially at an early stage, may also cause the extra blood trapped within the placenta to be forced back through the placenta into the mothers blood supply with the third stage contractions.32 33 This feto - maternal haemorrhage (FMH) increases the chance of future blood group incompatibility problems, which occur when the current baby's blood enters the mother's blood stream, causing an immune reaction which can be reactivated in a subsequent pregnancy, destroying the baby's blood cells and causing anaemia or even death.

EGF, TGF - alpha, and human milk stimulate fetal small intestinal cell proliferation in vitro, with the greatest increase in cell proliferation seen following exposure to human milk.

In most cases, with an increase of fluids and food, the body will respond and pass the excess cells.

Women with PCOS have cells that are less sensitive to insulin, resulting in higher insulin levels and increased production of male hormones.

Choose an obstetrician or health care provider Interview potential doctors Contact health insurance company about coverage Start and pregnancy and birth budget Discuss financial effects of pregnancy and baby with partner Stop smoking Stop drinking Stop using street drugs Talk to your physician about any prescription medications Drink at least 8 glasses of water every day Visit the doctor at least once per month or every 4 weeks Do not dye or perm hair Stop drinking coffee and other caffeinated beverages Exercise daily Start taking prenatal vitamins Eat foods rich in folic acid Eat iron rich foods Increase daily intake of whole grains, fruits and vegetables Nap as much as possible as fatigue is common Eat fish with low levels of mercury no more than 2 days per week Do not eat undercooked meats Do not eat unpasteurized dairy producs Do not eat cold cut deli meats Allow someone else to clean out the kitty litter, if applicable Limit exposure to chemicals Try to limit stress and tension Complete all prenatal tests — HIV, Chlamydia, Gonorrhea, Anemia, Blood Typing, Sickle Cell Anemia, Urine Screening and Rubella.

Milk sodium concentration is a marker of tight junction closure between mammary epithelial cells; with the onset of secretory activation (stage II lactogenesis) milk sodium concentrations decrease sharply as potassium concentrations increase [14].

Pregnant women, mothers who have recently given birth, and people with sickle cell disease also require increased folate.

The government has increased rotations of North Korean border guards, cracked down on brokers who assist people trying to leave, and prosecuted use of Chinese cell phones to communicate with the outside world.

There was also an association between using all four types of technology before bed and increased cell phone use at night, such as waking up to text someone, with watching TV resulting in the highest odds.

Disruptions to the ability of developing brain cells to form branching connections with other cells, using a specific microRNA — miR - 9, was associated with an increase in the strength of fear - related memories in adulthood.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Treating patients with an antibody called pembrolizumab (sold under the brand name Keytruda) caused these T cells to increase in number, says coauthor Kellie Smith, a cancer immunologist at Johns Hopkins University.

Silencing five genes whose expression negatively correlated with caspase activity significantly increased cancer cells» sensitivity to radiation (Genome Research, DOI: 10.1101 / gr.122044.111).

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

Increasing evidence suggests that fat is transported into the cells along similar pathways as glucose, Davis says, with the hormone insulin playing a critical role.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

At the same time it was also found that increased values for maternal and umbilical cord blood miR - 223 correlate with low regulatory T - cell numbers.

Immunohistochemical imaging of female human amniotic stem cells incubated with nanoparticles demonstrated a significant increase in uptake compared to male cells.

But when the researchers treated the resistant cells with the SYK inhibitor fostamatinib, they were able to increase the paclitaxel sensitivity of the cells.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Activation of beta - arrestin - 1 causes lung cancer cells to produce proteins associated with increased motility and invasion.

Plaque formation accelerated in the models transplanted with Tet2 - deficient bone marrow cells, likely through increasing macrophage - driven inflammation in the artery wall.

An overabundance of the bacteria Veillonella in the digestive tract may increase pain in patients with sickle cell disease (SCD).

By creating fibrous hydrogels with different levels of crosslinks, the team was able to show that cells surrounded by matrices with fewer crosslinks were better able to draw in fibers and increase the number of focal adhesions around them.

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

As more and more patients successfully manage diabetes with drugs that increase their insulin sensitivity, doctors and researchers have observed a serious problem: The drugs seem to decrease the activity of cells that produce bone, leaving patients prone to fractures and osteoporosis.

Furthermore, when healthy neurons in a dish were treated with serum from the patients and antibodies against leiomodin - 1, they did not survive, but removing the antibodies increased brain cell survival.

It was unlikely that all 24 genes would be altered simultaneously in any one bacterium, so the cycle was repeated over and over to increase the proportion of cells with mutations in all 24 genes.

They found that a certain protein, known as S100B, is markedly increased in astroglial cells from patients with Down syndrome compared with those from healthy controls.

DHA (docosahexaenoic acid) occurs naturally in cell membranes with the highest levels in brain cells, but levels can be increased by diet or supplements.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.