Sentences with phrase «cells increases over»

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

Its a dry oil so it absorbs right away and has high levels of Vitamin A so causes increased cell turn over helping with wrinkles, pigmentation, and acne!

However, despite constant reminders, alarming stastistics from AAA of Western and Central New York show that over the last five years there has been a 50 percent increase in cell...

In blood samples from these patients, the researchers found an increase in the percentage of gamma delta T cells, similar to what they observed in mice, which remained stable over years.

The building block of silicon solar cells has dropped so much in price that the venerable solar technology actually increased its share of the solar market over thin films in 2010, now accounting for nearly 90 percent of the photovoltaic market at a cost of roughly $ 1.20 per watt, not including installation.

It was unlikely that all 24 genes would be altered simultaneously in any one bacterium, so the cycle was repeated over and over to increase the proportion of cells with mutations in all 24 genes.

Immunotherapy caused an increase in peanut - specific T cells, accompanied by a change in the distribution of T - cell subtypes over time.

Roughly 2 % of people over age 35 have chronic glaucoma, in which fluid builds up inside the eyeball, leading to increased pressure and eventual death of cells in the optic nerve.

«This suggests that altering the ability of tumor cells to handle that stress or increasing the stress just a bit is enough to push the cell over the edge and it dies,» Dyer said.

With this technique, the Empa team has again been able to significantly increase the energy conversion efficiency from sunlight into electricity using CIGS thin film solar cells on flexible plastic foils — to a new record level of 20.4 %, representing a marked improvement over the previous record of 18.7 % established by the same team in May 2011.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

The tanks of electroactive materials can be made as large as needed — increasing total amount of energy the system can store — or the central cell can be tweaked to release that energy faster or slower, altering the amount of power (energy released over time) that the system can generate.

The authors highlight an intriguing finding, which was that the level of antibody tinkering — known as somatic hypermutation — did not increase in volunteers» B cells over time after seasonal flu immunization.

GLUT1 appears here because these cells have been taken over by the virus, which increases demand for more glucose to continue its infectious path.

But an even more surprising observation was that the cells didn't go away — they hung around at a 10-fold increase over prepregnancy levels for more than 100 days after birth (the equivalent of 4 years to 5 years in humans).

Then, they looked for an increase in cell growth over a few weeks, after which they extracted and sequenced DNA from the isolated microorganisms.

The increase in use of so called ride - sharing services — which allow prospective passengers to use a cell phone app to connect with owner - operator drivers — fuels debate over whether they can be a safer method of travel.

Over the course of about five seconds increasing numbers of red dots appear outside the nucleus, in the cell's cytoplasm.

However, this is unlikely given that the frequency of in - frame mutations remained stable over nearly four weeks in culture, that there was no significant increase in cell death between control cultures and those treated with X4 - ZFNs, and that the most common in - frame mutant was not expressed on the cell surface and thus can not maintain functionality.

The use of viral vectors in research is beneficial for a number of reasons, including but not limited to: helping to get difficult - to - deliver DNA into mammalian cells, increasing the efficiency of gene transduction, allowing for control over which cells are infected through viral pseudotyping, and ease of vector cloning and modification.

Urea secretion in the enhanced hiPS - HEP cells is lower than in hphep cells, but it increases over time.

The exception was one cell line, out of 5, where the mitochondrial DNA type associated with the transferred pronuclei increased over time to much higher levels than present in the embryo after PNT.

In a third of MDS cases, over time, very immature bone marrow cells called blasts may increase in number and fill the bone marrow, displacing the normal red and white blood cells and platelets that are produced there.

Same thing in giant turtles who normoglycemic or hypoglycemic for their entire life; Centenarians have reduced blood glucose levels and reduced blood glucose increase over the years, their blood glucose is monotonic plateau, where as elders dying below 80s show blood glucose rise each decade until their death, their pancreatic Beta cells can't secrete enough insulin and they are mildly pre - diabetic / insulin resistant.

Though the life expectancy of a person with sickle cell disease has increased dramatically over the past few decades, it is still much shorter than the average life expectancy.

Over time, these cells will increase in numbers.

«Over the past few years, City of Hope has seen an increase in patients coming for sickle cell disease treatment,» Rosenthal said.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

With a minimal 2 - hour therapy period, this study found that castor oil packs produced a «significant» temporary increase in the number of T - 11 cells that increased over a 7 hour period following treatment and then returned to normal levels within 24 hours later.

Research has shown that green tea can increase your metabolic rate up to 4 % over a 24 - hour period and also inhibit the movement of glucose into fat cells, which prevents high insulin spikes and fat gain.

Research findings over the last decade suggest inducing greater muscle cell activity by increasing the intensity of the exercise with the use of heavy weights in order to achieve greater growth.

«Increases in inflammatory activity are a very adaptive response when you have them once in a while, but to have lots of these activations over the course of a day or a week could potentially lead to chronic levels of inflammation which can be damaging to other cells and to organs.»

In fact, the 4g dose found in CELL - TECH HYPER - BUILD has been scientifically shown to increase max strength by over 40 % in just 12 weeks!

Because the fat spill - over from your obesity is preventing insulin to allow that increased sugar from the potato into your cells?

Not only does lactoferrin increase osteoblast activity, it also reduces the formation of osteoclasts, and these bone cells help to increase bone turn - over or bone loss.

In a 2015 double - blinded randomized placebo controlled trial (the gold standard for clinical trials) of over fifty pregnant women, with one group taking 1 mg of FA daily for four weeks, Lisa Houghton and her research team found that with supplementation the red blood cell levels increased but the levels of folate in breast milk did not change.

My diet virtually always increases LDL particle size (I have measured this for over a decade), such that they are not harmful (less oxidized), but rather beneficial, and can be delivered as necessary to make new cell membranes and cells.

Krill oil - an excellent source of phospholipid bound EPA / DHA with improved efficiency over fish oil at increasing red blood cell levels of omega - 3s, krill oil is an excellent source of phospholipid bound EPA / DHA with improved efficiency over fish oil at increasing red blood cell levels of omega - 3s.

People living sedentary lives eating 300g a day in carbs which is the SAD diet, are over eating and having all that increased insulin response shoving everything into their fat cells and they aren't excercising enough to utilize all those carbs.

Five studies conducted on 4,443 breast cancer survivors over a period of nine years found that the benefits of vitamin D help to increase communication between cells by turning on a protein that blocks cells division.

With use over time, the increase of blood circulation can help to stimulate skin cell regeneration for a youthful, radiant glow.

Studies have shown that it increases neuron plasticity — the ability of brain nerve cells to take over some of the activities of brain cells destroyed or damaged by stroke.

Lab Lowdown: A test of 34 women indicated that over 22 days of use, the lotion increased cell turnover, revealing brighter skin, according to evaluations.

Your skin benefits from increased levels of Glutathione due to its free radical destroying abilities as well as intense cell support, so you'll notice an obvious «glow» straight away and improved skin texture and volume over continued intake.

You'll find Retinol, the gold standard ingredient for topical skin care to even out skin tone, increase cell turn over and improve fine lines and wrinkles.

Malkovich met with near - universal critical praise and garnered an Academy Award nomination for the neophyte feature director — as well as supporting actress Catherine Keener and writer Charlie Kaufman — though Stipe and the film itself were passed over for a Best Picture nod.Despite Single Cell's increasing prominence in the industry, Stipe continued to support C - Hundred for smaller - budgeted niche features such as writer - director Tom Gilroy's Spring Forward and McKay's coming - of - age drama Our Song, both of which were featured at the 2000 Sundance Film Festival.

Although Hyundai has yet to name the new model, it promises increased range, performance, and durability over the outgoing ix35 Fuel Cell, known as the Tucson Fuel Cell here in the U.S.

It has been proven that when you place the Reticare protective sheet over electronic devices screens the survival rates of retina cells increase up to 83 %.

Because insulin resistance requires increased insulin secretion to maintain euglycemia, which over time also leads to β - cell failure, it is a core abnormality in type 2 diabetes.