Such images could help researchers learn how cancer
cells invade other tissues.
Not exact matches
Cancer Research UK scientists at The University of Manchester found that some melanoma
cells are particularly fast growing, but not very good at
invading the surrounding
tissue, while
other melanoma
cells are the opposite — highly invasive but slow - growing.
The research suggests that reducing production of the protein, called myoferlin, affects cancer
cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal
cell behavior, and by altering mechanical properties of cancer
cells — including their shape and ability to
invade — so they are more likely to remain nested together rather than breaking away to travel to
other tissues.
L1CAM protein (brown in top panel) resides in
cells poised to break from the cancer's bulk (
cells with b - catenin are brown in bottom panel) and
invade other tissues.
In this transition,
cells lose the ability to adhere strongly to each
other, enabling them to disperse and
invade tissues, where they can become established and multiply.
In the case of cancer, ineffective
cell adhesion allows tumour
cells to detach and
invade other tissues, thereby spreading cancer throughout the body.
In these circumstances,
cells from primary tumors in breast, colon, prostate, or
other organs
invade lung
tissue via the bloodstream.
The result is a fly tumor:
cells that proliferate,
invade nearby
tissues, and even metastasize to
other parts of the body.
Probably a number of embryonic genes, after being turned off for decades, are reexpressed in cancer
cells, enabling those
cells to regain their embryonic capacity to move around and
invade other tissues.»
Like
other cancers, breast cancer arises when the
cells of the breast lose control over their division and start to
invade neighboring
tissues.
However, cancer
cells often
invade other tissues where the availability of certain nutrients is drastically different or grow so quickly that the blood supply, and the accessibility to oxygen and
other nutrients that comes with it, becomes scarce.
Learn how loss of certain proteins makes prostate cancer
cells able to change shape, migrate, and
invade other tissues.
Cancer
cells acquire the ability to
invade and migrate, or metastasize, to
other tissues, through a process called Epithelial - Mesenchymal Transition (EMT).