Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer
cells involves inhibition of cyclin dependent kinase 2.
Genes
involved in DNA damage control and
inhibition of DNA synthesis [49], in particular Atm, Chk1 and Chk2, are also highly expressed in ES
cells, but decline during differentiation.