Sentences with phrase «cells leading to their death»

As a result they are unable to provide nutrients to the nerve cells leading to their death and burning pain.

Not exact matches

As irresponsible as that was — leading to the death of a covert asset who had infiltrated a dangerous terror cell — it taught Failing POTUS one thing: he has the authority to declassify anything any time.

In wet AMD, fluid leakage damages the RPE, leading to the death of light - sensitive cells and loss of vision.

The results could provide insights into the Zika virus» recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.

When this level was high enough, stress signals can lead to DNA damage and then trigger a form of cell death called parthanatos.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

There is also some evidence that repeated bouts of intense exercise on consecutive days can lead to white blood cell death or dysfunction.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

A malfunction of fatty acid regulation can, however, lead to cell death and — depending on the type of cell — trigger diseases such as diabetes.»

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

If another molecule, for example an antibody, touches this switch, a lethal mechanism is triggered that can lead to very fast cell death.

Roughly 2 % of people over age 35 have chronic glaucoma, in which fluid builds up inside the eyeball, leading to increased pressure and eventual death of cells in the optic nerve.

Now, two new studies have added another disease: multiple sclerosis (MS), an autoimmune disorder that strips away nerve cells» protective covers, leading to muscle weakness, blindness, and even death.

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.»

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

«After circulatory arrest, spreading depolarization marks the loss of stored electrochemical energy in brain cells and the onset of toxic processes that eventually lead to death.

Telomeres shorten every time a cell divides, and ultimately the loss of telomeres leads to cellular senescence, where cells cease to divide, and eventually, cell death.

Brain injuries, whether caused by trauma or neurodegeneration, lead to cell death accompanied by considerable functional impairment.

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

These proteins are thought to be a hallmark of Alzheimer's disease, and their formation may trigger other changes that lead to the death of brain cells.

«Shutting off vital tumour growth processes can lead to the death of human brain tumour - initiating cells.

Even a change in temperature of + / - 5 ° C subjects the cell to a heat shock or cold shock, which can lead to cell death after a few hours.

These defects, in turn, affect the cell's ability to generate energy and can potentially lead to cell death and are associated with aging and various neurological diseases.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

The researchers from UC Berkeley, UC San Francisco Benioff Children's Hospital Oakland Research Institute (CHORI) and the University of Utah School of Medicine hope to re-infuse patients with the edited stem cells and alleviate symptoms of the disease, which primarily afflicts those of African descent and leads to anemia, painful blood blockages and early death.

Then, in the presence of TB drugs, that increased respiration will lead to rapid death of the cells.

«Since cocaine works exclusively to modulate autophagy versus other cell death programs, there's a better chance that we can develop new targeted therapeutics to suppress its toxicity,» says Maged M. Harraz, Ph.D., a research associate at Johns Hopkins and lead co-author of the paper.

Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.

They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

The Duke team, lead by Timothy Haystead, Ph.D., a professor in the Department of Pharmacology and Cancer Biology, and Emily Derbyshire, Ph.D., assistant professor in the Department of Chemistry, conducted cell - based experiments to learn how the Takinib molecule influences a series of events to suppress cell death.

Plaque hinders neuronal activity by gumming up synapses (spaces between cells through which chemical or electrical information is transmitted), eventually damaging nerve cell branches and leading to neuronal death.

The prolonged presence of asbestos fibers lodged in the organ lining initiates a vicious cycle of chronic cell death and chronic inflammation that, over a period of many years, can lead to mesothelioma.

One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to cellular dysfunction or cell death.

Arising from the Schwann cells of the vestibular (balance) nerve, these tumors can grow to the point of damaging nearby structures — and can lead to death by compressing the brainstem.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

They found that mice that had beta cells in which autophagy didn't work properly showed elevated levels of toxic IAPP, which led to the death of the beta cells.

Mitochondrial diseases affect the batteries of the cell and can lead to muscular weakness, blindness, fatal heart failure, learning disability, liver failure, diabetes and can lead to death in early infancy.

«This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.

These similarities have led the team to dub the process microbe - programmed cell death, or microptosis.

Yet, this increases the probability that the other stem cells in the root stem cell niche will die due to the cold, leading to the plant's death.

Inflammation also erodes telomeres, the «caps» at the ends of chromosomes that protect genes from degradation, which can lead to early cell death, premature aging and even cancer.

«Lithium chloride is known to block many pathways that lead to brain cell death, while promoting others that lead to survival, like brain - derived neurotrophic factor, or BDNF,» says Saito, a research assistant professor at NYU Langone.

«Our results solve the controversy about the possible side effects of APC / C inhibitors,» says Malumbres, adding that: «we have shown in vivo that their elimination leads to the death of rapidly dividing cells.»

In healthy cells constant growth can overwhelm cellular factories like the ER, leading to cell stress and death, but cancer cells manage to keep their factories running at high capacity to fuel non-stop growth.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

«If you have an immature lung that is genetically predisposed to getting BPD, then it's getting hit with supplemental oxygen, this sets off inflammation and leads to cell death.

This leads to the death of some islet cells, in turn decreasing the secretion of insulin and causing type 2 diabetes.