Sentences with phrase «cells needs further»

But its utility for editing genomes of human and other cells needs further testing.

Not exact matches

The increasing use of in - vitro - fertilisation techniques, and the emergence of new possibilities involving human cloning, mixing of human and animal genetic elements, and the use of embryonic stem cells for research, among other things, brought the need for further teaching.

We need no further evidence, in my view, to prove scientifically that the social in - folding which we are undergoing is nothing other than the direct and logical extension, over our heads, of the process of cosmic in - folding which gave birth to the first cell and the first thought on earth.

He is totally shot away, the brain cells are rebelling inside his hippohead.He never ceases to amaze me.Does he really think that fans are so dense that they do nt remember what he says from friday till monday.What a jerk, if he wanted to look at fringe players then put Nene on, put Poyet on, give Amalifitano a go, even though he should be far more than a fringe player imho.He only used one sub out of three on saturday.Were we playing so well we did nt need to put on a couple of these so called fringe players.No, instead we got Cole.This guy is a grade1 muppet.Go talk a load of crap somewhere else, were all sick of your rubbish!

Some studies even indicate the possibility of carrying around cells from our great - grandmothers, though more research is needed on this to determine how far one can go back to tracing how many fetal cells are in a woman's body.

In a human brain, the cells would need to travel a matter of millimeters or centimeters, up to 20 times farther than the 500 microns tested here, he says.

Through strategic acquisitions, our portfolio was further developed to suit the emerging needs and complexities of the regenerative medicine and cell therapy industry.

Although de Lange notes that telomere shortening needs further investigation, she says there's now no doubt that telomeres play a critical role in limiting human cell division and that telomerase can reactivate the process.

Further preclinical work will be needed to use the herpes - loaded stem cells for breast, lung and skin cancer tumors that metastasize to the brain.

The team injected two milliliters of the stem - cell derived blood cells back into the patient — an amount far smaller than would be needed in a typical transfusion.

While these results suggest that boosting autophagy in the gut is generally beneficial, Hansen cautions that further research is needed: «Before we can consider regulating autophagy to manage disease, we need to learn a lot more about how the process works both in a single cell as well as in the whole organism.»

Further study is needed to gain a better understanding about whether exosomes entering cells via macropinocytosis have other features that could enhance their anti-tumor capabilities.»

According to researchers, such margin guidelines are needed because as many as two - thirds of the hundreds of thousands of suspicious skin moles removed each year in the United States require re-excision (further cutting out of mole cells missed on the first attempt).

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

«Specifically, the protein expression responsible for endothelial cell degeneration and tight junction damage we identified in this study needs to be confirmed through further tests.

«Further research is needed to characterize how we can potentially remove or block this protein to stop the proliferation of leukemia cells.»

So far, the electrode can not generate enough power to do this on its own, but even so it could reduce the amount of solar cells needed, making the process far cheaper, says Gamelin (Energy and Environmental Science, DOI: 10.1039 / c0ee00030b).

To do this, they need far more energy than healthy cells do.

The surprises are apparently far from over: Another kind of RNA can detect levels of small molecules that help a cell run smoothly, and switch genes on or off depending on the cell's needs.

While further research is needed to achieve these goals, the current approach can already help to characterize and assess treatments aimed at inhibiting influenza entry into cells.

The unexpected findings reported in the Cell Press journal Current Biology on September 8 highlight the urgent need for further study of the four genetically isolated species and for greater conservation efforts for the world's tallest mammal, the researchers say.

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

The far - reaching potential of iPS research, combined with a higher likelihood that cell lines will stay linked to a single donor (and that donor's health history), heightens the need for consensus, said Timothy Caulfield, research director of the Health Law Institute at the University of Alberta in Edmonton.

«We found that some of the active toxins manage to escape this route and intoxicate neighboring cells, so we need to investigate this further and find out how.»

The technique holds the greatest potential for treating diseases like muscular dystrophy, in which billions of far - flung cells need new DNA.

Coleman added that further research is needed to determine whether cell fusion events between normal human cell types result in genomic catastrophe and neoplastic transformation.

«Further studies are needed to understand the connections we're uncovering and the roles of these proteins, but we're clearly seeing evidence that these genetic variants have an effect in this type of immune cell.»

But he cautions that further research is needed to understand the effects of removing senescent cells.

Experiments with mouse embryo support cells that express mutant DUB or pseudo-DUB proteins show an impaired immune response when infected with a virus and impaired DNA damage repair when exposed to ionizing radiation, further validating the need for complex's correct structure.

Researchers know that the cells of species such as yeast, flies and humans make far more RNA molecules — copied from DNA — than they seem to need.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

Further tests — such as injecting the cells into mouse or chick embryos to see if they establish proper connections — will be needed to see if they are full - fledged neurons.

Further, its side effects are intolerable for many patients, limiting its use and creating an urgent need for more targeted drugs with minimal risks,» said Evan Snyder, M.D., Ph.D., professor and director of the Center for Stem Cells and Regenerative Medicine at SBP, and senior author of the study.

Giving PPAR - delta a boost with an existing drug was protective in HD cells and mice, but we'll likely need to research and test it further before it can go to the HD clinic.

And findings from clinical trials in humans can, conversely, generate hypotheses that need to be further investigated in cells or animal models in the lab.

Although further investigation regarding CSCs is still needed, there is evidence that these cells play an important role in the prognosis of cancer, progression, and therapeutic strategy.

To get there, researchers will need to resolve certain obstacles associated with CAR - T, including further customization of the technology to recognize specific / other tumor types, and predicting and limiting cross-reactivity, where CAR - T immune cells start attacking healthy cells as well.

The authors say that it's possible that the new trabecular meshwork cells generated from the stem cell treatment could eventually succumb to the same mechanisms that caused the fluid buildup in the first place, but further research is needed in that area.

However, further investigations are needed to clarify whether previous metabolic influences at the level of quiescent satellite cells in vivo can induce irreversible metabolic changes in cultured human myotubes.

The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.

Further, as people get older, their stem cells also tend to lose their ability to differentiate into new cell lines, including much - needed immune cells.

Muehlenbachs said further investigation is needed to determine whether it is limited to tapeworms or whether the situation is worse — that there's some «underlying biological phenomena» that might lead to transmissible cancer cells developing in other creatures that can pass them along to humans.

However, the further development this type of therapy requires a reliable source for the large amounts of homogenous functional patient - specific NK cells needed and this has led to the generation of NK cells from human induced pluripotent stem cells (iPSCs)[3].

Further research is needed to determine the best way to keep retinal cells from becoming senescent while maintaining their function.»

Further study is needed to translate these findings to humans as the researchers still have to determine if the same group of brain cells they targeted in rats also influences alcohol addiction in humans.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

«PRISM makes it far less cumbersome to get the data you need from a panel of cell lines.»

Although evidence that the system might work in human cells was presented, it needs further validation in more rigorous pluripotent assays [10], [11].

Patient - specific stem cells may offer an alternative to embryonic stem cells that will skirt the need for immunosuppressive therapy as well as the social and political ramifications of embryonic stem cell research, but their utility extends far beyond such groundbreaking advances and will assist future clinical practice and patient care.

Feldman believes that his findings thus far demonstrate that the combination of higher energy demands, lower body fat stores, and lower glycogen stores in LMHRs trigger increased production of LDLs for the purpose of carrying energy (triglycerides) to cells that need them, with cholesterol mainly along for the ride but also used by the cells for repair and other purposes, as needed.