My hope is to discover how age - related mitochondria dysfunction in
cells of the retina lead to macular degeneration.
Final Report Summary: Glaucoma is a silent disease that, over time, kills the nerve
cells of the retina leading to irreversible blindness.
Not exact matches
«The dog has a
retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model
of the disease,» said
lead researcher Ehud Isacoff, professor
of molecular and
cell biology at UC Berkeley.
Many diseases that
lead to blindness, such as glaucoma and macular degeneration, are caused by the death
of certain
cells in the human
retina that lack the ability to regenerate.
Without this waste, that part
of the eye «steals» glucose from the
retina,
leading to the death
of retinal
cells and likely vision loss.
The condition is hereditary or age - related, and causes degeneration
of the photoreceptors — light - sensitive
cells in the
retina —
leading to blindness.
Age - related macular degeneration, a disease that slowly degrades light - sensitive
cells in the
retina, is the
leading cause
of vision loss and blindness among people 65 and older, according to the Centers for Disease Control...
«With this finding, we have discovered that retinal horizontal
cells are required for maintaining the integrity
of the
retina and that their deficiency can
lead to retinal degradation,» explains Mu.
It also supports our belief that in the future, one might be able to use this approach for replacement
of cells lost or malfunctioning due to other more common diseases
of the
retina,» said
lead study author
cell biologist Jason Meyer, Ph.D., assistant professor
of biology in the School
of Science at Indiana University - Purdue University Indianapolis.
A team
of UK stem
cell scientists,
led by Dr. Robin Ali from UCL Institute
of Ophthalmology in London, has developed a new strategy for repairing the
retina by transplanting photoreceptor
cells generated in the laboratory from embryonic stem
cells.
Imagine how difficult it is for a patient and their family and friends when they lose vision, as is the case in a disorder such as age - related macular degeneration (AMD), where the unexpected sprouting
of weak and leaky new blood vessels
leads to death the ath
of the nerve
cells of the
retina.
The light information registered by these
cells is partially processed in the
retina and subsequently forwarded to the brain for further processing and integration with other sensory systems, eventually
leading to outputs such as endocrine regulation
of behaviours.
Cone - Rod Dystrophy 1 - Progressive Retinal Atrophy (cord1 - PRA) is an inherited disease
of the eye that affects the cone and rod
cells that make up the dog's
retina and often
leading to blindness.