GM - CSF is thought to act by moving progenitor
cells out of the bone marrow so that they can replenish the linings of blood vessels.
Not exact matches
The cancerous
cells win
out over the healthy blood
cells in the
bone marrow, which in turn leads to kidney problems when the cancer
cells make abnormal proteins instead
of antibodies.
And it's a production powerhouse, full
of life - giving stem
cells — pumping
out red blood
cells, white blood
cells,
bone cells, and fat
cells.
These
cells, which can become several different types
of blood
cells, are similar to the specialized stem
cells found in
bone marrow that can churn
out new blood
cells.
Infused with tiny «flavor
cells,» this
bone will keep your pup entertained; all you do is spread the flavor spread into the little divots on the sides
of the
bone, making it difficult for your dog to get all
of the yummy flavor
out.
Figuring
out how blank slate stem
cells decide which kind
of cell they want to be when they grow up — a muscle
cell, a
bone cell, a neuron — has been no small task for science.
But in multiple myeloma, plasma
cells grow
out of control in the
bone marrow, crowding
out healthy
cells.
This basic fact makes it difficult for researchers to discern the underlying mechanism
of the disease: «It's very difficult to figure
out what's wrong, because the
bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Cen
bone marrow is nearly empty
of these
cells,» said Bessler, the director
of CHOP's Pediatric and Adult Comprehensive
Bone Marrow Failure Cen
Bone Marrow Failure Center.
In 1868, however, the German pathologist Ernst Neumann discovered immature precursor
cells in
bone marrow, which turned
out to be the actual site
of blood
cell formation, also known as hematopoiesis.
Since the 1970s tissue engineers have been figuring
out how to grow skin,
bone, cartilage, and even parts
of vital organs using
cells harvested directly from patients.
Experience with lymphoma patients, who receive a transplant
of their own blood or
bone cells after radiation to wipe
out their cancer, has shown «there's no doubt it helps,» says
bone marrow transplant expert Nelson Chao
of Duke University in Durham, North Carolina.
In both acute and chronic myelogenous leukemia, immature white blood
cells in the
bone marrow multiply
out of control.
A sleep deficit
of just four hours affects by as much as 50 percent the ability
of stem
cells of the blood and immune system to migrate to the proper spots in the
bone marrow
of recipient mice and churn
out the
cell types necessary to reconstitute a damaged immune system, the researchers found.
The second branch
of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned
out to not primarily target the tumor
cells, but to act on the recruitment
of yet another tumor - promoting
cell population from the
bone marrow.
In
out -
of - the - body gene therapy, researchers take blood or
bone marrow from a patient and separate
out immature
cells.
Doctors built a trachea for Hannah by creating a «scaffold» or windpipe mold
out of non-absorbable nanofibers and seeding it with stem
cells from her
bone marrow.
Researchers at the Stanford University School
of Medicine have mapped
out the sets
of biological and chemical signals necessary to quickly and efficiently direct human embryonic stem
cells to become pure populations
of any
of 12
cell types, including
bone, heart muscle and cartilage.
When blasted with 10 Gy
of irradiation — enough to wipe
out all blood stem
cells in the
bone marrow
of normal mice — mutant mice that were unable to fully activate p53 experienced only a modest blood count drop.
In order to collect a large number
of stem
cells, the
bone marrow is stimulated to mobilize the stem
cells from inside the
bone marrow
out into the blood stream where it is easily accessible.
This work, published in «Blood», was carried
out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport
of the telomerase gene to the
bone marrow
cells using gene therapy, a completely new strategy in the treatment
of aplastic anaemia
By looking for
cell populations that would resemble the vertebrate chordamesoderm (a population
of mesodermal midline
cells that converge medially to give rise to the notochord; red in Fig. 1A), we identified segmental pairs
of mesodermal
cells on the non —
bone morphogenetic protein (BMP) body side (5) that stood
out by early and continuous expression
of colA1, encoding collagen type A (Fig. 2, A to D).
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Cancers
of the blood white
cells (lymphoma, leukemias) or those that crowd
out the red blood
cell - forming
cells of the pet's
bone marrow can also cause anemia (see M: E ratio).
It's called Panleukopenia because
of how the virus will temporarily wipe
out the infected cat or kitten's
bone marrow
of the precursor
cells that produce white blood
cells, red blood
cells, and platelets.
(ref) Phosphorus moves in and
out of bone through the blood stream because it is an essential ingredient in all living body
cells.
Leukemia is a progressive, malignant disease that involves
out -
of - control growth
of white blood
cells (leukocytes) in a dog's blood and
bone marrow.
White blood
cells and other inflammatory mediators will leak
out of the periodontal tissues and into the periodontal space (between the gum or
bone and the tooth).