Sentences with phrase «cells repair double»

Sung's expertise is in how cells repair double - stranded breaks in DNA.

Not exact matches

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

A major concern of the CRISPR - Cas9 approach, in which the double - stranded DNA molecule is cut, is how the cell responds to that cut and how it is repaired.

But after high - dose damage, too many cells would have double - strand breaks to replace them all, and repair would make more sense.

Kheradmand and her graduate student Ms. Ran You found that this form of carbon black caused double - stranded breaks in the cell's DNA, a state that is very difficult to repair, and activates T helper 17 cells, inducing chronic inflammation in the lungs.

Agata Smogorzewska, head of the Laboratory of Genome Maintenance, wants to understand how cells repair interstrand cross-links, a particular type of DNA damage in which the two strands of the double helix that normally twine about each other become physically linked.

They have also had several clues that the proteins are involved in DNA repair: They consort with known repair proteins, and mutant versions make cells virtually unable to repair DNA when both strands of the double helix are broken.

The injured pancreases, forced to repair themselves, soon swelled with double the normal number of beta cells.

More importantly, depletion of SA1 rendered those SA2 - mutated cells more susceptible to DNA damage, especially double - strand breaks (DSBs), due to reduced functionality of DNA repair.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits Repair of Interstrand DNA Crosslink, enhances DNA Double - strand Break, and sensitizes Cancer Cells to Cisplatin.

Mikolaj Slabicki (Buchholz, MPG)-- «A systematic investigation of DNA double strand break repair by a genome - wide RNAi screen in human cells» (2008)

Programmable nucleases, ZFN, TALEN and RGENs enable gene knockout in cultured cells and organisms by producing site - specific DNA double - strand breaks, whose repair via error - prone non-homologous end joining (NHEJ) or microhomology - mediated end joining (MMEJ) gives rise to frameshift mutations.

In dividing cells, BRCA1 helps repair a type of DNA damage known as double - strand breaks that can occur when cells are injured.

In Drosophila cells, «safe» homologous recombination repair of heterochromatic double - strand breaks (DSBs) relies on a specialized pathway that relocalizes repair sites to the nuclear periphery.

Cells divide for normal growth and repair, and to do this they double then split their DNA — their genetic blueprint.

But in a recent study, researchers described a balancing act that seems more counterintuitive than most: Bacterial cells prioritize transcription — the process of making RNA transcripts of genes as the first step in protein production — over repairing double - strand breaks in their DNA.

Cells lacking HRR must repair double - strand DNA breaks through more error - prone forms of DNA repair such as nonhomologous end joining.