Not exact matches
Investigators at Johns Hopkins report they have developed human induced - pluripotent stem
cells (iPSCs) capable of
repairing damaged
retinal vascular tissue in mice.
The white arrow shows iPSC - derived vascular stem
cells incorporating into a damaged
retinal blood vessel and
repairing it.
Future studies can now address how to maintain induced
retinal cell cultures in a proliferative, multipotent state and drive them to all the
retinal cell classes necessary to
repair a damaged or degenerating mature retina.
I firmly believe that basic knowledge is absolutely necessary; if we are going to be able to
repair injured retinas, we need to know how different
retinal cells are made normally, so we can remake them in a culture dish and use them to replace injured
retinal cells.
So for the last 15 years I've been studying
retinal ganglion
cell biology trying to understand why they fail to survive after injury or in degenerative diseases like glaucoma and also when their connections to the brain are interrupted why do they fail to regenerate to regrow, why do they fail to
repair themselves, it's this fundamental problem that leads to permanent vision loss in glaucoma.
His laboratory is currently trying to understand how to regenerate the diseased and injured visual system and is now initiating pre-clinical studies in humans using virtual reality to try to stimulation
repair and recovery of
retinal cells in glaucoma and other degenerative conditions.
His laboratory at Stanford University School of Medicine is developing novel stem
cell and nanotherapeutics approaches for ocular
repair, studying
retinal ganglion
cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.