Sentences with phrase «cells reprogrammed back»

Induced pluripotent stem cells (iPSCs)-- adult cells reprogrammed back to an embryonic stem cell - like state — may better model the genetic contributions to each patient's particular disease.

Not exact matches

One can not help but be intrigued by the implications of the fact that these adult stem cells can be induced to «reprogram» themselves back to their beginning — all the way back to their embryonic beginning.

The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.

Then his team turned to liver cells, which seemed from previous reprogramming experiments to be easier to send back to an embryonic state.

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell.

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

Such a recollection can be an advantage if scientists are looking to turn a reprogrammed skin cell back into skin cells, he noted.

«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again — the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

In mice, when adult cells are forced to fuse with stem cells, occasionally one of the adult cells reprograms itself, regressing back to an undifferentiated state.

In addition, scientists want to learn more about how an oocyte can reprogram a mature cell back into an ES cell.

The idea is that, by placing an adult cell from a diabetic, for example, into a human egg cell, the egg cell could turn back the clock of the adult DNA, or reprogram it, to its initial, pristine state.

In 2006, Japanese biologist Shinya Yamanaka found a solution: He reprogrammed skin cells from a mouse, turning them back into embryo - like cells, with the potential to grow into any tissue, simply by adding four genes.

In a laboratory study in Oxford, researchers have shown how it might be possible to reverse blindness using gene therapy to reprogram cells at the back of the eye to become light sensitive.

Although no one knows exactly how Wnt works, other studies have suggested that the signals may cause cells around an injury to revert to a state similar to that of stem cells, allowing them to be reprogrammed to grow back the missing part.

IPSC's are derived from the donated skin or blood cells of adults and, with the reactivation of four genes, are reprogrammed back to an embryonic stem cell - like state.

They will also use it to study cell reprogramming, in which an adult cell is converted back into its pluripotent state.

«That meant you could reprogram an adult cell nucleus back to an embryonic stage.»

It can reprogram human somatic (nonreproductive) cells, rewinding them back to an embryoniclike state.

Also, rather than using such compounds to reprogram cells all the way back to the pluripotent state, we are also working on more direct ways to change one type of cell directly into another.

Basically, the cells to be reprogrammed are removed from their normal culture system and exposed to the genes (in a gene delivery system), then put back into a new culture system.

This is beautiful science continuing directly from lasts week's publications to identify genes or factors critical for reprogramming a differentiated adult cell back into a pluripotent stem cell.

The first reports of the successful reprogramming of adult human cells back into so - called induced pluripotent stem (iPS) cells, which by all appearances looked and acted liked embryonic stem cells created a media stir.

Direct reprogramming could revolutionize the field of regenerative medicine, as it lets scientists transform one adult cell type into another without first having to revert back to the stem cell state.

Demonstrated that not a single «master» transcription factor, but rather a combination of factors, are important for reprogramming of cell fate from one somatic lineage back to a pluripotent state.

The first reports of the successful reprogramming of adult human cells back into so - called induced pluripotent stem (iPS) cells, which by all appearances looked and acted liked embryonic...

In 2010, Srivastava and a former postdoctoral fellow, Masaki Ieda, PhD, expanded on that breakthrough with direct reprogramming in a dish, which allows scientists to transform one adult cell type into another without first reverting back to a stem cell state.