Sentences with phrase «cells reprogrammed from»

This information will be particularly important for future evaluation of ES - like induced pluripotent stem (iPS) cells reprogrammed from somatic tissues that can be potentially used to derive pancreatic cells, cardiomyocytes or neurons for organ regeneration [21], [65]--[67].

In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.

Scientists can either harvest the cells directly from the patient, harvest them from another patient, or they can genetically reprogram adult cells.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

The MYC protein — which is one of the molecules used to reprogram iPSCs from adult cells — likely plays a role in dictating which sites in the genome are randomly methylated during the reprogramming process, the researchers hypothesized.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

«When we reprogram cells, we see small differences when we compare them to stem cells that come from an embryo.

Partial reprogramming of cells within prematurely aging mice's bodies extended the rodents» average life span from 18 weeks to 24 weeks, researchers report December 15 in Cell.

A group in Japan hopes to test a similar approach in humans using stem cells from reprogrammed adult cells within the next three years.

The team demonstrated that cell sex considerably influenced cellular uptake of nanoparticles and found that cells from men and women responded differently to reprogramming techniques used to enhance the ability of the cells to differentiate into a greater variety of cell types.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

ORDINARY cells from people with a genetic disease can be «fixed» by gene therapy and then reprogrammed to be stem cells that will produce a limitless supply of defect - free cells.

Then his team turned to liver cells, which seemed from previous reprogramming experiments to be easier to send back to an embryonic state.

That drug stops the tumour from reprogramming immune cells.

Unpublished results from the researchers hint that significantly fewer anomalies are seen in iPS cells created via virus - free reprogramming strategies, such as ones that use proteins or small - molecule drugs.

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

Like a cruel form of mind control, some cancerous tumours can reprogram some immune cells to «block» other immune cells from attacking, leaving the tumour free to grow.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

They then tried to reprogram skin cells from the animals, turning them into induced pluripotent stem cells (iPS), which are capable of forming other types of cell.

In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases — and eventually in treating them.

This year they succeeded in generating mini-livers, or liver buds, from stem cells that were taken from human skin and reprogrammed to an embryonic state.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

The research team took skin fibroblast tissue from adult mole - rats and reprogrammed the cells to revert to pluripotent stem cells.

These are cells taken from adult non-muscle tissues, such as skin or blood, and reprogrammed to revert to a primordial state.

In one promising approach, cellular reprogramming, stem cells can be generated by fusing adult skin cells with embryonic stem cells from existing cell lines.

Last week, scientists at Harvard University and Columbia University announced that they had proved the viability of a new way to study a disease — amyotrophic lateral sclerosis — by reprogramming cells from a patient to become pluripotent stem cells, which can then become any type of cell or tissue.

Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dish.

The research team from the Department of Biochemistry and Molecular Biology headed by Professor Susanne Mandrup are publishing a paper entitled «Browning of human adipocytes requires KLF11 and reprogramming of PPAR super-enhancers» in the January 1 edition of the scientific journal Genes & Development that describes their results from working with «brite» fat cells.

Like a Texan who keeps his drawl after moving to California, adult cells reprogrammed to resemble embryonic cells retain some signatures of the tissue from which they came.

Now researchers from the University of Southern Denmark have uncovered the mechanism by which white fat cells from humans get reprogrammed to become browner.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

In the future, such developments could enable cancer cells to be reprogrammed, thereby preventing them from dividing at an uncontrollable rate.

The term «pluripotent» refers to the fact iPS cells can be «reprogrammed» to become any type of cell, from skin to liver to nerve cells.

Patients could benefit from having their own cells reprogrammed into ones that could help treat disease, potentially eliminating the prospect of immune rejection.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

Researchers might generate personalized brain organoids from the reprogrammed skin cells of individuals with, say, schizophrenia and test which medications work best for patients with particular genetic profiles of the illness.

And by creating personalized organoids from the reprogrammed cells of patients, scientists could study disease in a very individualized way — or maybe even use organoid structures to replace certain damaged tissues, such as in the liver or spinal cord.

Researchers are also working to develop a trial where they will reprogram CAR T cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the cancer cells from more than one angle with the initial round of T - cell immunotherapy.

To conduct the study, scientists took dental pulp cells from donated baby teeth of three children with diagnoses of non-syndromic autism (part of the on - going «Tooth Fairy Project») and reprogrammed the cells to become either neurons or astrocytes, a type of glia or support cell abundantly found in the brain.

The group isolated cells from patient urine samples, amplified them, reprogrammed them into iPSCs and finally instructed them to become liver cells.

Two groups of researchers report today that washing human skin cells in similar cocktails of four genes enabled them to reprogram the cells to resemble those harvested from embryos.

Skin - producing cells called fibroblasts from the tip of an adult mouse's tail have been reprogrammed to make eggs, Japanese researchers report online October 17 in Nature.

Together with Kathrin Plath from UCLA, Vincent Pasque from KU Leuven led an international study into how adult cells reprogram to iPS cells.

This time, instead of using skin cells, the team reprogrammed lymphocytes (immune cells) from six entirely new bipolar patients, some of whom are known lithium responders.

«Maybe at the one - cell or two - cell stage,» Eggan and his colleagues reasoned, «there's still some of that stuff in there...» And if they picked the right moment of cell division, when these powerful reprogramming factors were still floating around in the periphery of the cell, they might be able to use drugs to temporarily freeze the cell in the middle of division, stick in the needle of a micromanipulator to suck out the embryonic DNA, squirt in DNA from an adult animal, and then kick - start the process of reprogramming — hours, perhaps even days after an egg had been fertilized.

The idea is that, by placing an adult cell from a diabetic, for example, into a human egg cell, the egg cell could turn back the clock of the adult DNA, or reprogram it, to its initial, pristine state.