Sentences with phrase «cells reprogrammed into»

The 2012 platform also repeats previous calls for expanding federal funding «for the stem - cell research that now offers the greatest hope for many afflictions — with adult stem cells, umbilical cord blood, and cells reprogrammed into pluripotent stem cells — without the destruction of embryonic human life.»

Patients could benefit from having their own cells reprogrammed into ones that could help treat disease, potentially eliminating the prospect of immune rejection.

Efficient B cell reprogramming into iPS cells and transdifferentiation by C / EBPa (Graf's group in collaboration with Beato's, Nature, 2014; Mol Cell, 2012; Stem Cell Reports, 2015; Nature Cell Biol 2016; Cell Stem Cell, 2016).

Not exact matches

Making personalized, or «autologous» stem - cell treatments, can make the process go a lot faster, since a person's cells don't need to be shipped out, reprogrammed, then reinserted into the body.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

A few months ago, a team at Harvard succeeded in reprogramming cells using a virus that did not integrate into the cell's DNA.

The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.

«Altering Huntington's patients» skin cells into brain cells sheds light on disease: Reprogrammed brain cells exhibit «symptoms» of fatal disorder.»

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

To solve these problems, Hingtgen's group wanted to see whether they could skip a step in the genetic reprogramming process, which first transforms adult skin cells into standard stem cells and then turns those into neural stem cells.

Researchers chemically reprogrammed human stem cells into small bundles of functional brain cells that mimic the developing brain.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

Previous failures in reprogramming primate cells probably happened because the egg ran into roadblocks — portions of the body cell's DNA known as reprogramming - resistant regions, say study coauthor Mu - ming Poo, director of the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai, and his colleagues.

Adding ascorbic acid to culture medium could help overcome the main roadblock in reprogramming human, mouse cells into iPS cells

Since it is proteins that do the reprogramming, rather than the genes that make them, the researchers reasoned that they simply needed to get enough of the proteins into the target cells.

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embcell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embCell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

Further ahead, he is looking to an emerging technology known as induced pluripotent stem cells (iPSCs), in which adult cells are reprogrammed to be like embryonic stem cells so they can transform into any type of cell.

For the first time, specialised cells have been reprogrammed into the equivalent of embryonic stem cells without using genes that might trigger cancer.

The team demonstrated that cell sex considerably influenced cellular uptake of nanoparticles and found that cells from men and women responded differently to reprogramming techniques used to enhance the ability of the cells to differentiate into a greater variety of cell types.

Cellular reprogramming turns an adult cell, such as a skin cell, into an induced pluripotent stem (iPS) cell.

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

They reprogrammed the skin cells, rejuvenating them into an embryolike state (using the four - gene approach described in 2007).

Such a recollection can be an advantage if scientists are looking to turn a reprogrammed skin cell back into skin cells, he noted.

«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again — the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

This maneuver «froze» the cells in a quiescent phase of their division cycle and may have made their chromosomes more susceptible to being reprogrammed to initiate the growth of a new organism after the nuclei were transferred into an egg.

They then tried to reprogram skin cells from the animals, turning them into induced pluripotent stem cells (iPS), which are capable of forming other types of cell.

The scientists found that if they replaced MYC with LIN41 in the cocktail of genes involved in reprogramming — meaning if they used O, S, K and LIN41 — they could convert adult cells into iPSCs with the same efficiency.

In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases — and eventually in treating them.

But to convert adult cells into embryonic - like cells means genetic reprogramming, for example with a virus, and the reprogrammed cells do not yet match embryonic stem cells.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Two new studies document one reason why: Adult cells maintain a memory of their original tissue even after being reprogrammed into iPS cells.

The researchers also employed a cutting - edge technology developed by their collaborators at Columbia University to reprogram the child's skin cells into early progenitor cells, then differentiate those into lung cells, the front lines of influenza infections.

Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dish.

«To put this into perspective, reprogramming to induced pluripotency in cell culture takes several days to weeks whereas reprogramming to totipotency in zygotes occurs in less than 24 h,» says Kikuë Tachibana - Konwalski, who devotes her laboratory's research to understanding the molecular secrets of egg cells and zygotes.

The observations add weight to the theory that transforming an adult cell's DNA into an embryonic state is a gradual reprogramming process, Hochedlinger says.

The challenge is to reprogram the energy storing white fat cells into so - called «brite» (brown - in - white) fat cells in the body's white adipose tissue and thus make adipose tissue burn off excess energy as heat instead of storing it.

Stem cells could likewise be reprogrammed into differentiated organ cells.

Doctors at Kobe City Medical Center General Hospital used her skin cells to grow iPS cells, which were reprogrammed into retinal cells and implanted in her eye.

Since Yamanaka's breakthrough, dozens of groups have reported other ways of reprogramming cells as well as techniques to control differentiation of stem cells into neurons, cardiovascular cells, and other tissues of interest for regenerative medicine.

In addition, scientists want to learn more about how an oocyte can reprogram a mature cell back into an ES cell.

By reprogramming skin cells into nerve cells, researchers at Karolinska Institutet are creating cell models of the human brain.

In the online edition of Science, he and his colleagues report that Oct4 and Sox2 were capable of converting neonatal foreskin fibroblasts into cells similar to Yamanaka's, whereas Nanog significantly boosted the frequency of reprogramming and Lin28 upped it by a moderate amount.

The group isolated cells from patient urine samples, amplified them, reprogrammed them into iPSCs and finally instructed them to become liver cells.

Together with Kathrin Plath from UCLA, Vincent Pasque from KU Leuven led an international study into how adult cells reprogram to iPS cells.

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) provides a powerful tool for in vitro disease modeling and drug screening.