Sentences with phrase «cells rodent models»
Because of the rarity of bRG cells rodent models, the mechanisms controlling proliferation and self - renewal of these neural stem cells remain largely unexplored.
https://science.institut-curie.org/ Not exact matches
Dr Sottile added: «This new system gave us an advantage over previous rodent models as we could study more accurately how specifically human cells would be affected by a decrease in temperature.
You would create a mouse model of attention deficit / hyperactivity disorder (ADHD) or depression and dose the rodent with molecules carefully designed to close one cell receptor or open another.
Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy - induced neuropathy and HIV.
Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.
It has been reported that in a Tg rodent (rat) model expressing hIAPP, diabetes onset coincides with a ∼ 60 % deficit in β cell mass (Butler et al., 2004), which resembles the ∼ 70 % loss of β cell mass observed in patients with T2D (Butler et al., 2003).
Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.
We investigate cellular and molecular mechanisms of retinal degeneration and regeneration using rodents and human cells as model systems.
Review of «Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.
Madalena Pereira (Ader, TUD)-- «Cell - based replacement of retinal pigment epithelium in rodent models of retinal degeneration» (2014)
To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;
Inhibition of DPP - 4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner
The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.
Paul Sawchenko uses cell biological and genetic approaches in rodent models to study how stress - responsive systems are organized at a molecular level within the body and particularly within the brain.
In a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung function.
In rodent models of T1D induced by streptozotocin, it was found that THC mitigated the severity of the immune response, transiently prevented hyperglycemia and loss of pancreatic insulin, and decreased expression of pro-inflammatory elements including CD3 + T cells, IL - 12, IFN - γ and TNF - α (50).
The rodent models have shown that microglial cells, which normally provide an immune defense for the central nervous system, become abnormally activated in ALS to produce neurotoxicity.