Sentences with phrase «cells targeted against»

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

Jacob's team has transplanted the back - up or «alternative» respiratory machinery from the mitochondria of lower organisms to human cells, showing that it can protect against pathological stresses, and even lethal poisons like cyanide, that target the mitochondria.

«It's blue sky, but we can certainly envision making different inhibitors of channels with monobodies, which could perhaps be targeted against harmful cells and microorganisms.»

Drugs that targeted the RAS pathway showed little activity against the tumor cells.

Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

As with innate immunity, the adaptive immune system — the T cells and antibodies produced by B cells that target specific molecules on invading cells — contributes to pathology or may also fight against it.

Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»

For patients, down the road Dr. Ohashi envisions a new era of combined therapies to simultaneously target and kill these suppressive cells while augmenting the immune response against cancer.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

They prepared a similar weapon against liver cancer by piggybacking rhenium 18 on antibodies that target HBx, a viral antigen made by cancerous liver cells.

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

HIV's favorite target is the CD4 T cell, which orchestrates our entire immune response against the disease.

Pyrethroids, the main class of pesticides used against bedbugs today, targets sodium channels in bedbug cells, just like DDT.

Once in the lymph nodes, these vaccines can stimulate production of huge numbers of T cells against the vaccine target.

Such hybrid carriers have several advantages: low toxicity, efficient intracellular delivery and protection of siRNA against premature degradation prior to reaching the target cells.

Scientists from Tomsk Polytechnic University together with their colleagues from St. Petersburg and London have elaborated a new approach to deliver anti-viral RNAi to target cells against H1N1 influenza virus infection.

Scientists were able to selectively target the cells that cause autoimmune disease by dampening down their aggression against the body's own tissues while converting them into cells capable of protecting against disease.

«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.

A T - cell marker panel that can identify subsets of tumor - associated T - cells allows scientists to identify and target subpopulations of T - cells playing unique roles in the immune response against a tumor.

Neoantigens are molecules on cell's surfaces that are produced by DNA mutations that are present in cancer cells but not in normal cells, making neoantigens ideal targets for immune therapy against cancer, say the scientists.

An alternative approach, most common for anti-infectives, is to use compounds («phenotypic inhibitors») which have already been shown to be active against the target organism in the living pathogenic cell as chemical leads for improvement by Medicinal Chemistry, towards systemically active Candidate Drugs.

They also identified targets for potential therapies: bolstering levels of either a particular chaperone or a growth factor in brain cells can protect against the toxic effects of misfolded proteins.

Furthermore, niclosamide showed significant antitumor activity against a panel of cervical cancer cell lines via inhibition of mitochondrial respiration and the mammalian target of rapamycin (mTOR) signaling pathway [42].

The discovery could prove to be a major asset in the fight against several pathologies via the targeting of a single immune cell component.»

'» In all patients who were vaccinated, his team found tumor - targeting T cells, and he noted that in addition to augmenting pre-existing T cell responses, the vaccine also stimulated new T cell responses against tumors.

Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.

Targeting inhibitory proteins within cytotoxic T cells as a means to improve T cell activity against cancer has led to impressive clinical successes, but only in a minority of treated patients (1).

Enhanced phosphorylation of Nbs1, a member of DNA repair / checkpoint complex Mre11 - RAD50 - Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR / ABL - positive leukemia cells.

Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.

Once inside, the cells could provoke an immune response that would confer immunity against the target viral protein.

Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.

He said traditional drugs to treat tapeworm infection — which target the whole organism at the larval stage - might not have been effective against tapeworm cancer cells, and it's also unclear whether chemotherapy for normal human cancer cells could have helped shrink the tumors.

They were the first successful forms of immunotherapy for lymphoma, with rituximab (Rituxan), a monoclonal antibody against the CD20 target, now the standard of care for all B cell lymphomas.

His previous work at IDRI has included investigations into the physiology of the M.tuberculosis (Mtb) cell wall, the development of an overexpression library for high throughput target identification, and the development of target based high throughput screens for potential drug candidates against Mtb.

«If we can come up with strategies to carefully target fat cells, then I think activating this pathway could be effective in the fight against obesity,» he says.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

T lymphocytes, or T cells, are removed from patients» peripheral blood and reprogrammed with a gene, CAR, that when expressed actually redirects all of the T cells against a single target.

Next, we demonstrated the expression of PSCA and MUC1 in NSCLC, followed by the generation and confirmation of the specificity and efficacy of PSCA - and MUC1 - targeting CAR T cells against NSCLC cell lines in vitro.

It is Dr. Chou's hope that, by treating colon cancer stem cells with DAC and then exposing them to immune cells that have been primed to recognize NY - ESO - 1, he can generate a targeted and durable immune response against these cells without harming healthy cells.

This customized library is screened against the target to detect binding or modulation of target activity in biochemical or cell - based assays.

In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.

Stephan's foggy early morning brainwave illuminated an unexpectedly simple approach to making cell - based immunotherapy, in which cancer - targeting immune cells are enlisted to fight tumor cells, as effective against solid tumors as it has been against blood cancers like leukemia.

Adults with advanced renal cell carcinoma after targeted therapy against vascular endothelial growth factor (VEGF)

This study just found (in mice) that the common therapeutic target for the anti-TNF medication treatment of IBD, may actually protect against intestinal inflammation by inhibiting pathogenic T - cells.

«We're using the whole tumor cell, and that allows us to stimulate a response that's broad, that's against multiple targets, and that's against targets that are unique to that individual patient,» Avigan said.

A pilot study demonstrated this combination elicited a powerful, targeted immune response directed against osteosarcoma cells in patients suffering from this type of cancer.

One of their key modes of action is targeted against microbial membranes and cell walls, which are then disrupted by the higher frequiencies being generated.

In other words, when agents get a warrant to use a cell - site simulator against a suspect target, and in doing so inevitably capture private phone information from countless innocent bystanders, the new policy still lets agents use that incidentally captured information against those bystanders if they get court permission.