Sentences with phrase «cells targeted for»

«The AAV - DJ / 8 subtype combines multiple serotypes, giving us a broader range of cell targets for the delivery of our CRISPR / Cas9 system,» Dr. Hu said.

Not exact matches

Gene therapy, for example, frequently involves using a virus to deliver a gene to the cells that scientists are targeting.

The technology's possibilities are staggering — in theory, allowing medical scientists to do everything from cure genetic disorders like sickle cell disease to identify gene targets for combating HIV.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Most of the action is coordinated by white blood cells, which direct the lines of attack like football coaches, churning out antibodies that target the opponent for destruction.

One recent example: Stemcentrx, which rode an unproven approach targeting cancer stem cells to a summertime financing round of nearly $ 250 million and a $ 5 billion valuation, the most for a venture - backed drug maker and second to Theranos in health care.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

The Japanese government has set a target price of ¥ 2.2 million — around US $ 18,000 — for fuel - cell vehicles by 2025.

What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investCell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investcell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

A 17 - year - old California girl won $ 100,000 in a national science competition for her creation of a nanoparticle that can target and kill cancer cells.

Eilersen has announced it is releasing a new series of digital load cells in a hygienic (aseptic) design for dynamic and process weighing, filling, packaging, and general weighing applications targeted primarily at food and pharmaceutical customers.

The load cells transmit weight gain information to the controller, which steps down the feed rate to a trickle and stops the conveyor immediately before reaching the target weight to compensate for material in flight.

These are the main target cells for HIV.

CoolScultping, for instance, uses an applicator to target, cool and eliminate fat cells without damaging your skin.

And it CAN be a good for political organizing, if your targets are in populations with high cell - phone and / or Twitter usage (for instance, younger — and plugged - in — urban black and latino voters).

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

«xIAP has other roles in the cell, such as regulation of cell death, so it is a tricky target for treating inflammatory diseases.

A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

These results significantly advance understanding of how cancer cells are made to move during metastasis and may provide more precise targets for drugs to stop cancer metastasis in patients where there are oncogenic mutations.

Still, «for something that really tends to interfere with your everyday life, I would think that a treatment that targets just these cells could be appropriate,» she said.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.

The autophagy machinery in yeast cells is similar to that in human cells, and Ohsumi's work, which began in the 1990s, gives scientists new targets for possible treatments.

Nevertheless, our results show that RNA modules have great potential in biotechnology for controlling processes in bacterial cells in a targeted manner.»

The new technology, described in the journal Molecular Cell, offers a new way to seek drug targets for many diseases, not just Parkinson's, says Timothy Lu, an MIT associate professor of electrical engineering and computer science and of biological engineering.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context.

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Heacell research at Moores Cancer Center at UC San Diego Health.

If it does, he will then study BCCA chemical networks in living cells to determine promising targets for new drugs.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

To hunt for drugs that target these cells, Piyush Gupta, a molecular biologist at the Broad Institute at the Massachusetts Institute of Technology, and colleagues genetically engineered ordinary human cells so that they acquired some of the properties of cancer stem cells, including being impervious to chemotherapy.

«The paper shows that the timing of development is important for the mechanism that a cell uses to find a target,» he says.

But while Venter's synthetic genome will be housed within an existing bacterial cell, other scientists are aiming for the even more ambitious target of building an entire living cell from the basic chemical ingredients.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma.»

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

«Our work strongly supports that cancer stem cells are the main source of growth in these tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper.

For example, an MDM2 - targeting drug shrank deep - tissue fat cell tumors in just one out of 20 patients in a phase I safety trial, published in 2012.

In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carriers.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

We designed chimeric antigen receptor (CAR) T cells that specifically target podoplanin (PDPN), a key protein for the progression of solid tumors, including GBM.»

By combining this strategy with cancer cell - targeting materials, we should be able to develop a therapy for glioblastoma and other challenging cancers in the future.»

To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR - T cells.

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

Artist's conception of nanoparticle - carrying immune cells that target tumors and release drug - loaded nanoparticles for cancer treatment.