Sentences with phrase «cells than mice»

In a study of obese mice that received a diet rich in either coconut or safflower oil, mice that received the coconut oil were found to have made much less fat cells than mice that received the safflower oil.

First, they found that the mice on a high - fat diet had many more intestinal stem cells than mice on a normal diet.

Not exact matches

Yesterday's ruling effectively said that Feng Zhang's adoption of the technique in human and mouse cells was, in fact, a new and patentable invention rather than an «obvious» extension of Doudna's and Charpentier's work.

(The reason for growing the organ within a rat rather than a mouse was that the scientists needed to produce enough insulin - producing cells to reverse diabetes» effects in mice.)

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

Residual tumors, spawned from the remaining cancer cells, were 3.5 times smaller in the treated mice than in untreated mice.

«We've been hearing about their potential for more than a decade, but the results have always been in mice and rats, and no one has shown they're safe or effective in humans long term,» says Robert Lanza of Advanced Cell Technology in Marlborough, Massachusetts, the company that carried out the stem cell interventCell Technology in Marlborough, Massachusetts, the company that carried out the stem cell interventcell intervention.

In the latest research, described online this week in the journal Cell Reports, Stelzer used the reporter system in mice to discover that imprinted methylation in developing and adult tissues is actively regulated rather than merely maintained in stable fashion.

Encouragingly, Hochedlinger's cells do seem to be safer than conventional mouse iPS cells.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

The mice produced more memory T - cells, which kick in when bugs come back, than mice not given the drug.

Like the Rosetta Stone that scholars used to decode hieroglyphics, researchers trained the algorithm with more than 4,600 T cell receptors and then used it to correctly assign 81 percent of the human T cells and 78 percent of mouse T cells to one of 10 different viral epitopes.

The mice treated with rapamycin also ended up with better quality memory T - cells than the control mice.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

They're much more complex than similar cells in a mouse.»

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

When the huntingtin gene is deleted at an age older than four months, these mice appeared to stay healthy, despite having lost their huntingtin genes in cells all over their bodies.

The brown cells are new neurons, which are more numerous in active mice than sedentary mice, and the blue cells are mature neurons.

The study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation of bone in mice,» says Darwin Prockop, a stem cell researcher at Texas A&M College of Medicine in Temple, who was not involved in the work.

One, known as MIRA - 1, turned out to kill more than cancer cells: It was toxic in mice.

In order to generate enough energy, the bone cells in our mice therefore take up much more glucose than normal.»

Instead mice injected with stem cells developed a far greater number of synapses, or connections between neurons, at the damaged site than control mice did.

When injected with cancer cells, animals housed there developed tumors 80 % smaller than those in control mice, or no tumors at all.

But a study of mice shows that breast cancer cells decamp in groups, and the clumps of cells have a better chance of establishing a colony than loners do, Kevin Cheung of Johns Hopkins University reported December 7 at the annual meeting of the American Society for Cell Biology.

Fat tissue taken from mice on a high - fat diet rich in omega - 3 fatty acids (right) has fewer inflammatory immune cells (shown in green) than fat tissue taken from mice that did not receive the omega - 3 supplement (left).

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

BYE BYE BUDS Mice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (leMice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (lemice of a healthy weight on a regular diet (left).

In both cell cultures and mice, these mineralized viruses proved to be significantly more infectious — and deadly — than the native viruses.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

Their embryos had more profound defects than were seen in the Esrp1 - null mice, including craniofacial and forelimb defects, and the complete absence of lungs and salivary glands — two organs made up largely of epithelial cells.

Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was active in 24 per cent of airway cells after two months, a far better proportion than achieved by other delivery methods (New Scientist, 10 March 2001, p 19).

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

These organoids had more stem cells than those isolated from wild - type mice.

Stem cells harvested from embryos rather than adults remain the most powerful for cloning and other purposes; Yang's team showed that cloning from such cells succeeded in 49 percent of attempts and led to 18 mouse pups.

For example, they succeeded in inserting a gene into a predefined position in the genome (knock - in) in more than 60 per cent of all manipulated mouse cells.

In a boost for a controversial theory of aging, mice engineered to make a human protein that sponges up cell - damaging molecules live 19 % longer than other mice.

«In a single dose, APC - mimetic scaffolds led to two - to ten-fold greater expansion of primary mouse and human T cells than Dynabeads.

An APC - mimetic scaffold that was engineered to activate a specific type of CAR - T cell was able to generate higher numbers of the modified T cells over longer periods of culture than analogously designed expansion beads, and the resulting cells were similarly effective in killing the lymphoma cells in the mice.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

The analysis found the mice that were exposed to BPA had a significant decrease in beta cell mass and lower levels of insulin secretion than the control animals.

The experiments also left white blood cells cancer free for more than 30 weeks in live mice.

In humans, as in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fat.

However, mice lacking Ggamma13 in their olfactory cells required more than 8 minutes to perform the same task.

«Simply by counting cell types, we immediately saw that there were more Tregs in the older mice with diabetes than any other group.»

«Stem cells function far differently in mice than in monkeys,» says biologist Shoukhrat Mitalipov, a senior scientist in the Division of Reproductive and Developmental Sciences at Oregon National Primate Research Center and lead author of the monkey study.

Previous attempts to do the same in monkeys, however, have failed — a disappointment because monkeys are more similar than mice to humans, and thus likely a better harbinger of how stem cell treatments will fare in people.