Sentences with phrase «cells than normal mice»

However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

Not exact matches

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

In order to generate enough energy, the bone cells in our mice therefore take up much more glucose than normal.»

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

When they exposed these mice to the cold, the animals developed far fewer beige fat cells than did normal animals, suggesting that macrophages were key to browning of white fat.

Experiments on mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human growth factor, can put infant heart cells on a path that mimics normal growth rather than stalling out.

He notes, however, that other attempts to stimulate bone growth in mice by manipulating cell signaling proteins have produced denser than normal bones — and he's surprised that Helms's team didn't see the same.

In another experiment, mice lacking the cells that produce serotonin scratched less than normal mice when exposed to a skin irritant.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

When the researchers injected extra copies of the betatrophin gene into the liver of normal mice, the animals» pancreases responded by making as much as 30 times more β cells than usual.

However, by the time these mice reached adulthood, around 8 months old, the level of photoreceptor cells in these knockout mice was less than half the normal level.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.

First, they found that the mice on a high - fat diet had many more intestinal stem cells than mice on a normal diet.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.

They found that the mice developed earlier and more severe disease than mice that had normal Tob1 expression in all cells including CD4 +.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Some studies have identified a number of regions of methylated DNA (one key way in which epigenetic changes occur) that are different in fat cells of mice fed high - fat diets than in cells of mice with normal diets.

Remarkably, outcomes following loss of the switch mirrored what the group had previously observed when they physically removed the gene itself: the lungs of mutant mice contained many more melanoma cells than did lungs of normal mice.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

Takeda et al. engineered mice that were either unable to produce a particular LPA receptor on their T - cells, or that produced less LPA than normal.