CD4 + T
cells transfer HIV through connections called virological synapses that require interactions between several cell membrane proteins, such as ICAM - 1 and LFA - 1.
Not exact matches
Using lymphoid tissue infected with
HIV, the scientists compared
cell death rates between
cell - to -
cell and
cell - free virus
transfer.
«We could potentially
transfer these specialised super potent killer T
cells into patients, or we could treat patients with proteins that can drag these specialised killer T -
cells into the right spots, specifically to the hot spots where
HIV can hide on antiviral treatment,» Professor Lewin said.
In addition, transgenic autologous hematopoietic stem
cells can be successfully transplanted in
HIV - infected individuals [18] and several phase I adoptive
transfer trials of CD4 + T
cells treated with R5 - ZFNs in
HIV infected individuals are currently underway.
The low - cost technology could allow us to
transfer the gene mutations that make some people naturally resistant to
HIV into other people's immune
cells, creating a potentially permanent cure for the virus.