Sentences with phrase «cells transferred into»

We found that naive T cells transferred into MHC negative or allogeneic environments often fail to survive because of rejection and / or competition by natural killer (NK) cells, rather than failure to recognize a particular MHC allele.

Here we controlled for some of the features that differed among the earlier studies, and analyzed both the survival and expansion of naive CD4 + T cells transferred into MHC syngeneic, allogeneic, or MHC negative environments.

Not exact matches

Nanoengineers might dig into the molecular structure of battery materials to speed up how they transfer more voltage per cell.

This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).

In somatic cell nuclear transfer, a nucleus from a mature body cell is transplanted into an egg cell without a nucleus.

To solve this, West proposed «therapeutic cloning» — taking the nucleus out of a patient's cell, transferring it into an egg cell to create a cloned embryo, then using that embryo to derive patient - matched stem - cell lines.

In a one - in - a-million event, only slightly more likely than running into a flying reindeer, the coral DNA might have moved from her blood into a virus - like genetic element that transferred it into the egg cell that formed Rudolph.

This summer Wagers published research [subscription required] showing that when muscle stem cells were transferred into mice with a type of muscular dystrophy, the rodents» muscle function improved.

While previous vectors have only been able to penetrate the cochlea's inner hair cells, the first Nature Biotechnology study showed that a new synthetic vector, Anc80, safely transferred genes to the hard - to - reach outer hair cells when introduced into the cochlea (see images).

In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cells.

In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.

Rodríguez - Perales, Torres and Ramírez have shown that by transferring the RGEN components into primary human cells, regions of the exchanged chromosomes in some tumours can be marked, thus generating cuts in those chromosomes.

This maneuver «froze» the cells in a quiescent phase of their division cycle and may have made their chromosomes more susceptible to being reprogrammed to initiate the growth of a new organism after the nuclei were transferred into an egg.

Using a standard inverted microscope, researchers can then lift the desired cells and transfer them into individual sample tubes or microtiter wells.

The nuclei are inserted into egg cells which have had their original nucleus removed, a process called nuclear transfer.

Other researchers have previously cloned animals, including mammals, by transferring nuclei from embryonic cells into such enucleated eggs.

One approach would be to identify immune cells in a tumour, grow them in a lab, and then infuse them back into the patient — a technique called adoptive cell transfer.

During infection, many viral pathogens transfer their genetic information into the host cells as double - stranded RNA (dsRNA).

Some researchers have been trying an alternative route: engineering gene - delivery vehicles such as viruses to transfer neurotrophic - factor genes directly into brain cells.

In one such approach, researchers surgically remove brain cells, use viruses to transfer genes to the cells, and then graft them back into the animal's brain tissue.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

This group of about 800 receptors plays a central role in transferring signals from the environment into the cell and is of great interest for drug development.

Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy human ADA genes into a modified mouse retrovirus — a type of virus that can enter human cells and transfer new genetic material right into the DNA strands in their nuclei.

«We think that differentiation is a way that opens some doors and makes it easier for nuclear transfer programming to go back into embryonic stem cells.»

However, this method raises the following problem: in every nuclear transfer, a small number of defective mitochondria are transferred into the healthy egg cell.

A technician in a Kyoto University lab uses an electronic pipette to transfer cells into petri dishes before they are placed into an incubator.

Day 0: Around 9,000 stem cells are transferred into V - shaped wells and suspended in a cocktail of vitamins, amino acids and (for the first six days) Y - 27632, a chemical to prevent the stem cells from committing suicide.

The patent gives California - based Geron Corp. exclusive rights to animal embryos prepared by transferring the nucleus of a quiescent diploid donor cell into a suitable recipient cell up to and including the blastocyst stage.

The scientists starved the cells into quiescence, then transferred their DNA - carrying nuclei into egg cells stripped of their own nuclei.

Next, the Stanford group plans to engineer their retroviruses to transfer IL - 4 genes directly into cells in live mice.

Venter has already transferred the genome of one species into the cell body of another.

In order to survive, a virus must infiltrate a host organism undetected and transfer its genetic material into the host's cells, where it will use the host to replicate and proliferate.

His team's approach is based on gene therapy, where a «tame» virus is harnessed to transfer a gene into target cells in the recipient.

«We could potentially transfer these specialised super potent killer T cells into patients, or we could treat patients with proteins that can drag these specialised killer T - cells into the right spots, specifically to the hot spots where HIV can hide on antiviral treatment,» Professor Lewin said.

But the next step — transferring the nucleus — was different; rather than fusing the donor cell with the enucleated egg cell, the team removed the donor nucleus with a very fine needle and injected it into the donor egg.

A nucleus extracted from such cells could be transferred to an egg cell emptied of its own DNA to create an embryo and ultimately to bring new life into the world.

Meanwhile, the Food and Drug Administration (FDA) has erected roadblocks in front of a fertility specialist and a stem cell biologist who want to clinically test a different IVF strategy: swapping out a woman's mitochondria by transferring chromosomes from her egg into an egg from another woman.

Scientists managed to transfer the extinct frog's nuclei into the egg cells of a barred frog (right), but so far, the embryos have yet to fully develop.

I already mentioned dye - sensitized solar cells, which is about trying to improve the efficiency of charged transfer of an electron going from a molecule into a semiconductor.

To confirm that these cells were, in fact, stem cells, the scientists transferred them into the kidneys of adult mice.

PARTICLE acts in three different ways to prevent expression of the MAT2A gene: 1) by winding around the MAT2A gene to create a DNA: RNA triple helix structure locking down the MAT2A gene promoter, 2) by binding the messenger RNA product of the MAT2A gene and preventing it being used for MAT2A protein synthesis and 3) transferring MAT2A messenger RNA into intracellular vesicles that are subsequently ejected from the cell.

Bacteria share DNA with other organisms with which they come into contact, so an antibiotic - resistant gene can transfer from one type of bacterium to another, and a bacterial cell can become resistant to numerous antibiotics at once.

Transferring the mutant B cells into mice, the researchers further showed that Foxo1 has a vital role in the cycling of B cells between light and dark zones.

Using a process called somatic cell nuclear transfer (SCNT), a team from Oregon Health & Science University (O.H.S.U.) in Portland implanted the contents of individual skin cells from adult male rhesus macaques into each of 304 macaque egg cells stripped of their genetic material.

The researchers then transferred nuclei from nearly 1900 of the cultured cells into egg cells whose nuclei had been removed, eventually producing six calves.

After many attempts, CC was created by coaxing the nucleus of a cell from a calico cat into an enucleated egg; an electrical spark prompted the hybrid to divide, and the resulting embryo was then transferred into a surrogate mother.

Of the 29 early embryos created by somatic - cell nuclear transfer and implanted into various ewes by Roslin researchers, only one, Dolly, survived, suggesting that the technique currently has a high rate of embryonic and fetal loss.

She also collected visceral fat tissue from women undergoing hysterectomies and found that when the fat secretions had more of the FGF2 protein, more of the cells formed cancerous tumors when transferred into mice.

The new finding brings a measure of closure to a story that first rocked the science world in February 2004, when Hwang and colleagues at Seoul National University announced they had cloned a female donor's cell by transferring its nucleus into one of her egg cells stripped of its nucleus in a procedure known as somatic cell nuclear transfer (SCNT), and harvested embryonic stem cells from the resulting fusion.

That was enough time for the team to transfer new nuclei into dozens of egg cells.