Not exact matches
Further experiments showed that the metabolic and the
cell cycle oscillators could in fact be
uncoupled.
To accomplish this deception biologically, Bartfai and Conti genetically engineered mice to overexpress
uncoupling protein 2, which causes the mitochondria in
cells to produce heat instead of ATP, the fuel source of cellular activity.
Liu, K.Q., Bunnell, S.C., Gurniak, C.B. & Berg, L.J. T
cell receptor - initiated calcium release is
uncoupled from capacitative calcium entry in Itk - deficient T
cells.
To
uncouple the effect of out - of - plane curvature from the lateral confinement experienced by the
cells in these geometries, we compare our results to experiments performed on narrow adhesive tracks.
Uncoupling cell proliferation from apoptosis and possibly from
cell migration can lead to pathologies such as cancer.
Indeed,
uncoupling of the Exocyst subunit Sec5 from GEF - H1 impairs RhoA activation, generation of traction forces and
cell dissemination.
These compounds aren't just hard to pronounce, they're hard for our
cells to tolerate and lead to mitochondrial
uncoupling, DNA damage, free radical cascades and other
cell - damaging events that accelerate the aging process and contribute to disabling disease.