Sentences with phrase «cells using genetically»

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In the second half of 2017, the United States Food and Drug Administration (FDA) approved two immunotherapies that use genetically engineered T cells (CAR - T cell therapy) to fight cancer.

These stem cells would be genetically identical to the patient from whom the original adult cell was taken and could be used for research and therapeutic purposes.

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

Lexicon's solution is to create a bank of genetically altered mouse cells that can quickly be used to develop knockout strains.

In optogenetics, light is used to control genetically modified cells.

«We concluded that stem cells used in cardiac therapy should be drawn from healthy donors or be better genetically engineered for the patient.»

Researchers in optogenetics can control genetically modified brain cells using light but because of these modifications, the technique is not yet deemed safe to use in humans.

They use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two — into the tissue, where a nanoparticle turns the near - infrared light into blue light, and that directs the activity of genetically engineered immune cells.

Only stem cells from healthy donors or genetically engineered cells should be used in treating cardiac conditions.»

«This shows iPS cells have a lot of problems, but that doesn't mean they don't have potential — just not with the established methodologies used to create them,» says tissue engineer Anthony Atala, director of Wake Forest University Baptist Medical Center's Institute for Regenerative Medicine in Winston — Salem, N.C. «It's a solvable problem, but it looks as if one should look away from methods that don't genetically modify the cell.»

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat epilepsy in rats, and it could soon be tested in humans.

With materials and instructions from the kit, I will introduce CRISPR into the bacteria cells, and use it to rewrite a tiny part of their DNA, creating genetically altered cells that happily thrive on streptomycin.

Moreover, Dolly's birth did not prove that cloning could be used to create animals from cells that had been genetically manipulated.

The tremors and other movement impairments of Parkinson's are triggered by the death of dopamine - producing cells in the brain, so the investigators used flies that had been genetically engineered to have their dopamine cells die off as they age.

The new product is made using genetically engineered hamster cells in fermenters, and requires a number of refining stages.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

In addition to using normal breast cancer cells in the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYR1.

You describe a technique to use genetically tweaked red blood cells to deliver drugs that would otherwise break down after...

* No sperm necessary: By combining genetically altered cells, Japanese scientists create a healthy baby mouse using only female DNA.

Invasion assays using Glioblastoma (GBM) cells on the left lacking Id4, in comparison to the same cells being genetically engineered to express Id4 on the right.

With the help of optogenetics, the research group was able to deactivate specific genetically altered brain cells using light.

Using this test, the team found that genetically - intact HIV hides in specific subsets of CD4 + T - cells.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body, such as bacteria, viruses or foreign cells.

Because the cells used to seed the platform can come from anyone, the new tissues could be genetically identical to the intended host, reducing the risk of organ rejection.

«A few years ago we recognized that stem cells could be used to continuously deliver these therapeutic toxins to tumors in the brain, but first we needed to genetically engineer stem cells that could resist being killed themselves by the toxins,» he said.

The team led by Dr Rubén López — of the UAB's Department of Cell Biology, Physiology and Immunology and Institute of Neuroscience, and the Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED)-- used a genetically modified mouse that produces the human form of IL - 37 to study the function of this protein.

Using cell models and genetically engineered mice, the authors then could reproduce kidney disease changes upon expression of APOL1 gene variants, but the disease required the presence suPAR.

Discuss how mouse models can be used to study human immune responses against leukemia (using primary or genetically modified leukemia cells) and melanoma

In the new study, published yesterday in PLOS Biology, Heitman and colleagues set out to explore whether genetically identical, unisexually reproducing C. neoformans cells were using aneuploidy to generate offspring that differed from themselves.

Scientists in Germany last year reported that they could transform adult mouse spermatogonial progenitors into cells genetically resembling ESCs by using a different growth medium for just a few weeks.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

Gorelick, the lead author, Halpern and Alice Hung of Carnegie, along with Luke Iwanowicz and Vicki Blazer of the Fish Health Branch of the U.S. Geological Survey, used genetically modified zebrafish that show estrogen receptor activity on a cell's DNA.

Schaal, dean of the faculty of arts and sciences at Washington University in St. Louis, called for more effective communication and public engagement by scientists in explaining their work, both to policy makers and to the general public, across a range of topics — climate change, evolution, stem cells, and use of genetically modified organisms (GMOs) in agriculture.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat an epilepsy - like condition in rats, and it could soon be trialled in humans.

Using a technique called optogenetics, they were able to turn on genetically engineered brain cells in rats using a blue light delivered directly to those cells via an optic fUsing a technique called optogenetics, they were able to turn on genetically engineered brain cells in rats using a blue light delivered directly to those cells via an optic fusing a blue light delivered directly to those cells via an optic fiber.

The study, «Modulating Behavior in C.elegans Using Electroshock and Antiepileptic Drugs,» just published in PLOS One, has led the researchers to build on the current animal models for inducing seizures via electroconvulsion in the genetically modifiable C.elegans that only has 302 brain cells called neurons.

Through the use of localization - based super-resolution microscopy, researchers are able to photoactivate, image and follow these genetically encoded fluorescent proteins, one at a time, to study what is happening inside a cell at the molecular level.

The embryo used to derive an ES cell is not genetically identical to the donor of the cell that is transformed into an iPS cell, so researchers expect some discrepancies in gene activity.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

Ploegh envisions the technique being used to create a new type of personalized therapy in the future — your own cells could be isolated, used to create stem cells that differentiate into erythroblasts, genetically modified to carry a molecule, and reinjected into your body.

For their study, the Max Planck researchers used genetically modified fish larvae, in which the targeted muscle cells of the heart chamber were destroyed by the administration of a substance.

«By using the patient's own skin cells, we should be able to generate transplantable OPCs that are genetically identical to the patient's natural OPCs,» Yang said.

We used yeast — a system easily accessible genetically — and asked the question how does one part of the cell know what is going on in another part.

Simultaneously, they made use of a genetically encoded fluorescent protein to measure bipolar cell output.

Doctors use a technique called preimplantation genetic diagnosis (PGD), in which a single cell is removed from the embryo and genetically tested.

A study led by UCLA's Drs. Robert Prins and Linda Liau, both UCLA Jonsson Comprehensive Cancer Center members, looked at the impact of a combined treatment using a chemotherapy drug called decitabine and genetically modified immune cells or T cell immunotherapy.

No one thought that it would be possible to take a cell from an adult mammal and use it to grow another, genetically identical clone.

The rescue of memories, which changed both the structure of neurons as well as the behavior of mice, was achieved using optogenetics, a method for manipulating genetically tagged cells with precise bursts of light.

Moreover, examination of the role of Mcf1 can be dissected genetically using mutants that either interfere with its endocytosis into target cells, or Rac signalling mutants that hint at early and unexpected Mcf1 mediated effects on the phagocyte cytoskeleton.