Sentences with phrase «cells with abnormalities»

Scientists can use the technique to develop populations of cells with abnormalities that lead to disease.

What does it mean if a quarter of the cells from the placenta carry a genetic abnormality — how likely is it that the child will have cells with this abnormality, too?

Not exact matches

In a study, his team found that female incest survivors had abnormalities in the ratios of immune cells, compared with untraumatised women, exposing them to autoimmune diseases.

Because hair cells are also critical for the sense of balance, mice with damaged or missing hair cells show balance abnormalities.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

«This is the first demonstration that cells carrying a genetic disease are capable of spreading into the normal mammalian brain and lead to the manifestation of behavioral abnormalities associated with the disease,» says Francesca Cicchetti, professor at the Université Laval Faculty of Medecine and researcher at Centre de recherche du CHU de Québec - Université Laval.

The abnormalities seen with the iPS cells may be related to viruses used to create them.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

When they administered minocycline — a tetracycline antibiotic with anti-inflammatory properties commonly used to treat bacterial infections, acne and arthritis — many of the abnormalities in the astroglial cells were corrected and there were more healthy interactions between the astroglia and neurons compared to the control cells without the defect.

Results suggest that while isotretinoin was associated with a change in the average value of some laboratory tests (white blood cell count and hepatic and lipid panels), the average change across a patient group did not meet the criteria for high - risk and the proportion of patients with laboratory abnormalities was low, the authors report.

Different abnormalities such as cleft palates, small skulls, and problems with higher brain function were seen depending on which cell types lacked Smc3 expression, but the phenotypes were similar to those seen in CdLS patients.

In a report published in Development, they describe early abnormalities in the way Huntington's neurons look, and how these cells form larger structures that had not previously been associated with the disease.

In 2013, Dr. Sharifi discovered that prostate cancer cells with the genetic abnormality survive ADT by producing their own androgens.

It was clarified that GLUT4 with abnormalities in the N - glycan chain was transiently translocated to the cell membrane but was rapidly internalized without retention on the cell membrane, and that the N - glycan chain played a role in retaining GLUT4 on the cell membrane.

While assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI)-- which involves the direct injection of sperm into the egg cell — can overcome head or tail abnormalities in sperm, recent animal research suggests that fertility doctors must use these techniques with care.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

Further testing could reveal genetic abnormalities or other problems with the cells that would prevent their use in therapies.

On examination, the patient - derived Purkinje cells showed structural abnormalities in dendrites (the projections neurons use to take in signals) and signs of impaired development of synapses (junctions with other neurons).

Various procedures are currently available to detect genetic defects in embryos prior to implantation, but these approaches are often invasive, requiring the removal of cells from the growing embryo, and do not simultaneously detect both chromosomal abnormalities and DNA sequence variations associated with genetic disorders.

Through whole - genome sequencing of individual egg cells, the new method detects chromosomal abnormalities and DNA sequence variations associated with genetic disorders.

Through this technology, scientists obtained stem cells from individuals with a genetic abnormality that confers increased susceptibility to schizophrenia, and they observed deficits during nerve development that could be traced to a specific gene called CYFIP1, which helps maintain a nerve cell's structure.

«Studies of fetuses and babies with the telltale small brains and heads of microcephaly in Zika - affected areas have found abnormalities in the cortex, and Zika virus has been found in the fetal tissue,» says Guo - li Ming, M.D., Ph.D., a professor of neurology, neuroscience, and psychiatry and behavioral science at Johns Hopkins» Institute for Cell Engineering.

In these tests, StemFit not only delivered higher cell proliferation, but also showed characteristics such as homogeneity of gene expression compared with iPS cells cultured with four other media without any chromosomal abnormalities.

«In fact, abnormal cells with numerical and / or structural anomalies of chromosomes have been observed in as many as 80 - 90 % of human early stage embryos following in vitro fertilization,» says Professor Thierry Voet from the Wellcome Trust Sanger Institute, UK, and the University of Leuven, Belgium, another senior author of this paper, «and CSV tests may expose some degree of these abnormalities.»

(14,15)-RRB- have found age - related satellite cell attrition consistent with the senescence of a subset thereof; moreover, one such study (15) reported that decreases in the number and quality of satellite cells with aging are reliably associated with elevated expression of p16Ink4a (contrary to (14)-RRB-, and with secretory and proteomic abnormalities consistent with a rising burden of senescent cells.

Howard Hughes Medical Institute researchers have tracked the cause of insulin resistance in the offspring of patients with type 2 diabetes to abnormalities in their mitochondria, the cell's «power...

December 17, 2013 Cancer genetics pioneer Janet Rowley, 1925 - 2013 A pioneer in connecting the development of cancer with genetic abnormalities, Janet D. Rowley, MD, the Blum - Riese Distinguished Service Professor of Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago, died from complications of ovarian cancer on December, 17, 2013, at her home.

It is unfortunate that the investigators did not assess insulin secretion, insulin action, or systemic inflammation in early - aging BubR1H / H; INK - ATTAC mice, with and without ablation of senescent adipose cells, but reasonable to be optimistic that doing so would yield some normalization of age - related metabolic abnormalities.

Several targeted drugs (e.g., imatinib [Gleevec ®], dasatinib [Sprycel ®]-RRB- are effective for treating CML because they attack cells with the Philadelphia chromosome, the genetic abnormality that is the hallmark of this type of leukemia.

We are now collaborating with Sheng Ding, PhD, a chemist at Gladstone, to find a drug - like compound that could correct the abnormality in patient cells.»

In previous studies, TERT - / - mice have been generated on either a C57BL / 6J or a 129 / C57BL / 6J mixed genetic background strain, both of which have «very heterogeneous and unusually long telomeres,» again raising the possibility that any developmental abnormalities might be due to subpopulations of stem cells with critically - short telomeres.

Background: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood - cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer.

Sickle cell disease (SCD) is caused by a genetic abnormalities in the hemoglobin genes which leads to the production of abnormally shaped mature red blood cells, provoking various acute and chronic complications with an accompanying high mortality rate [1].

According to the University of Maryland Medical Centre «people with abnormal levels of red blood cells or abnormalities in their red blood cells» should be cautious about vitamin B12 (31.)

Telomeres protect a cell's chromosomes from fusing with each other or rearranging — abnormalities which can lead to cancer — and so cells are normally destroyed when their telomeres are consumed.

The abstract concept that human cells contain chromosomes made of genes was made more concrete through these karyotypes and the photos of children with chromosomal abnormalities.

Often the initial pre-cancerous abnormalities of cervical cells are caused by infection with the human papillomavirus (HPV).