Not exact matches
«Cells sequester trash in
compartments called autophagosomes» Cells follow a set recipe for recycling: First, the autophagosome is formed around the trash, next autophagosomes are transported and merged with lysosomes — another
cellular compartment — and finally, the contents are degraded and either secreted or reused
by the cell.
Because the amount of ROS present in cells is tightly regulated
by iron - dependent processes in the mitochondria (the
cellular compartments in which energy is generated), the researchers had proposed iron import into the mitochondria to be essential for this process.
Wolfram syndrome is caused
by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another
cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.
Importantly, these newly identified helper proteins channel the
cellular garbage
by a «self - eating» pathway (autophagy) to the lysosome, a
compartment of cells dedicated for destruction and recycling.
Bits of misfolded proteins processed
by specialty organelles may accumulate in the main
compartment of the cell, the cytosol, where they can be tagged for disposal
by the
cellular garbage service.
Apoptosis stimulated
by the 91 - kDa caspase cleavage MEKK1 fragment requires translocation to soluble
cellular compartments.
Autophagy (more specifically macroautophagy) is the process
by which
cellular compartments, such as membranes and organelles and also protein aggregates, are recycled back into their building blocks [122].
It has recently been proposed that the primary role of
cellular senescence is in mitotic
compartments of fixed size in which spatial considerations dictate that a deleted cell is replaced
by a neighboring cell.
«Cells sequester trash in
compartments called autophagosomes» Cells follow a set recipe for recycling: First, the autophagosome is formed around the trash, next autophagosomes are transported and merged with lysosomes - another
cellular compartment — and finally, the contents are degraded and either secreted or reused
by the cell.