Sentences with phrase «cellular components by»

Glutathione is a well - known antioxidant that prevents damage to important cellular components by ROS.

Not exact matches

But when dominant occasions in animals and the occasions in empty space in cells are included in the animal and cellular societies, then the activities of the societies can be explained by the activities of the components when they are components of those societies.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

By blocking a cellular rather than viral component, the treatment may minimize the evolution of drug - resistant viruses.

«Our goal was to find what happened to cellular components affected by the WNT10A mutation to make better treatments.»

NAD + is central to intermediary metabolism, the intracellular process by which food is converted into cellular components in the body.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

Because of that, many different components are present in minute quantities, which inevitably leads to random variations in cellular processes which are also called «noise» by chemists.

In his research, Forth uses an optical trapping technique to quantify the forces exerted by components of cellular structures like the mitotic spindle.

While previous research had shown that TTLL7 modifies microtubules (hollow tubes that transport cellular components and act as highways and scaffolding in the cell) by adding one or more molecules of the amino acid glutamate, exactly how has remained a mystery.

Other hypersensitivity reactions (II, III and IV) are mediated by other antibody classes, immune cells or cellular components.

«By identifying the most important cellular components that viruses hijack and re-wire, we can more intelligently design drugs that target the virus's weak points and where it interacts with the host.»

The Gladstone Center for Cell Circuitry (GC3) addresses this fundamental challenge by developing single - cell tools to map how cellular components connect into circuits.

(9) Indeed, the degenerative aging process is by definition one in which the organism progressively accumulates damage to its cellular and molecular components over time, so any genetic or environmental factor that leads to a greater burden of such damage will bear some resemblance to the aging phenotype, irrespective of the causal origin of the defect or its relationship to «normal» aging.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

It involves cell degradation of unnecessary or dysfunctional cellular components, which ensures cellular survival during starvation by maintaining cellular energy levels.

Mitochondrial damage further drains cellular energy by creating a disproportionate need for repair, perpetuating a vicious cycle.21 Mitochondrial dysfunction can affect immunity, digestion, cognition and any energy - intensive system within the body and is a key component of many chronic illnesses.

The secondary display is a 3.5 - inch, 320 by 240 - pixel QVGA LCD touchscreen running Android 1.6 (Cupcake) minus the cellular and GPS components.

Defended an LTE cellular network provider in a lawsuit by a California - based wireless broadband network component provider in an action for breach of a contract to purchase component parts necessary to build an LTE network in West Texas.