How can we reconstruct the circuitry of the cell to qualitatively and quantitatively assess the phenotype from measurements
of cellular constituents?
Our bodies must have an adequate supply of purines and pyrimidines to form
major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP).
The Keap1 - Nrf2 system has evolved to respond to intracellular oxidative stress; in particular the generation of reactive electrophiles produced from oxidation of endogenous
cellular constituents as well as xenobiotics [2]--[4].
Molecular biologists went on to crystallize most of the essential components of cells and are today accustomed to thinking
about cellular constituents — for example, ribosomes, mitochondria, membranes, DNA and proteins — as either chemical machinery or the stuff that the machinery uses or produces.
«Those types of cartilage have
different cellular constituents, so we would have to really investigate the molecular underpinnings regarding how these cells are regulated,» the researcher said.
Gained experience in the chemistry of
major cellular constituents and their metabolism using a spectrophotometer to obtain the spectrums of different solutions.
The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for
the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis.