Sentences with phrase «cellular defect in»

These findings suggest HLHS may be associated with a fundamental cellular defect in the heart muscle that can compromise blood flow in patients.

The cellular defects in DC created an opportunity for Agarwal and his collaborators to attempt immunosuppression - only pre-transplant conditioning.

Though further characterization of the developmental and cellular defects in mouse Boule mutant testes is needed to determine the full extent of similarity in developmental and cellular defects between mouse and Drosophila Boule mutants [61], our data demonstrate a key physiological requirement of Boule in sperm development and conservation of its male reproduction function between two distant lineages of a protostome (Drosophila) and a deuterostome (mouse).

These mutations are also relevant to melanoma and to numerous associated birth defects of organs including the ear, eye, brain, reproductive, digestive and respiratory tracts, hemophilia, and cellular defects in protein transport, organelle biogenesis and apoptosis.

Not exact matches

A forward genetic screen in Drosophila melanogaster (fruit flies) identified mutant copies, or alleles, of a gene called cacophony associated with defects in autophagy and cellular homeostasis.

This has important therapeutic implications, as surgical repair will not be able to address the cellular muscle defect in HLHS patients, noted Lo.

This is the case of mitochondrial disease, a rare condition caused by defects in the «cellular powerhouse.»

Disruption of this structure caused DNA synthesis to proceed beyond the normal template boundary, resulting in altered telomere sequences, telomere shortening, and cellular growth defects.

Using real - time cellular imaging to monitor the changes in aged flies» neuron activity before and after learning, Davis and his colleague Ayako Tonoki found structural connectivity defects between a set of neurons known as dorsal paired medial neurons and mushroom body neurons; these defects prevented long - term memories from forming.

In order to dissect these defects, we utilize a unique approach including deep assessment of patient phenotype, clinical genetic testing to identify underlying genetic contributions to these features, and the application of combinatorial functional omics (transcriptome, metabolome, etc.) to uncover the pathological cellular states that result from these genetic changes.

The grains are not very small, but the cellular structures and other defects inside the grains that are commonly seen in welding seem to be controlling the properties.

The common characteristic of all types of SCID is absence of T - cell - mediated cellular immunity due to a defect in T - cell development.

The primary defects that cause muscle degenerative diseases are affecting distinct cellular pathways; accordingly, there is a large variability in clinical pathology and onset.

Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

(9) Indeed, the degenerative aging process is by definition one in which the organism progressively accumulates damage to its cellular and molecular components over time, so any genetic or environmental factor that leads to a greater burden of such damage will bear some resemblance to the aging phenotype, irrespective of the causal origin of the defect or its relationship to «normal» aging.

Gene Yeo, PhD, assistant professor of cellular and molecular medicine, will apply innovative technologies to detect abnormal patterns of RNA in neurons and discover molecules that reverse these defects.

Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine - producing nerve cells and ultimately symptoms of Parkinson's...

But defects of the DNA repair system in brain cells could contribute to the accumulation of potentially disruptive and toxic metabolites of cellular insult, and lead to neurological dysfunction.»

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