Sentences with phrase «cellular development in»

Not exact matches

«There are two ways to connect a car: There's the original telemetry readings, but the new phase, now that we have 4G is infotainment devices, and the vehicle as a hotspot,» says Larry Zibrik, vice-president of Market Development at Sierra Wireless, a Vancouver - based company that's become a global leader in the modules that allow machines to communicate over cellular networks.

And there have been developments in cellular therapies to treat cancer, with two treatments aiming for approval by the end of 2017.

Upon an imaginary earth of constantly increasing extent, living organisms, being only loosely associated, might well remain at the mono - cellular stage (if indeed they got so far); and certainly Man, if free to live in a scattered state, would never have reached even the neolithic stage of social development.

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

In the future, she adds, «we might be able to alter the course of brain development» with drugs targeted at the cellular anomalies and delivered during pregnancy.

Cancer cells are opportunistic in the sense that they hijack cellular events necessary for development and survival.

The use of MRI for research, rather than diagnostic, purposes is a relatively new development, and clinical investigators in the imaging community often do not understand the basic cellular and neural circuitry issues as well as they should, he says.

He says it's also important to understand the protein's biological role in cellular signaling and normal animal development as well as to consolidate its role in human cancer development, progression and drug - resistance.

In addition to the dangers posed to fetal development, unregulated amounts of nanoparticles in the environment are now known to affect us at the cellular level, and the genetic consequences could be at the root of the greatest public health crises, including heart disease, hypertension, obesity and diabeteIn addition to the dangers posed to fetal development, unregulated amounts of nanoparticles in the environment are now known to affect us at the cellular level, and the genetic consequences could be at the root of the greatest public health crises, including heart disease, hypertension, obesity and diabetein the environment are now known to affect us at the cellular level, and the genetic consequences could be at the root of the greatest public health crises, including heart disease, hypertension, obesity and diabetes.

Those deletions tended to involve genes that affect cilia, cellular structures that are important for signaling and patterning in embryonic development.

The next step in this line of investigation, already in development, is to learn how cellular responses vary, on a molecular level, among roots of flooded plants when the hormone is not present, which would make it possible to create a response model where this signaling path would play a key role.

They found many of the 131 regions were related to genes involved in growth and development and cellular function and maintenance.

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life.

«Bacteria development marks new era in cellular design: Scientists have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production.»

«This opens the door to an entirely different aspect of [the] cellular environment that we had not previously considered in eye development.»

As researchers at the Max Planck Institute of Biochemistry report in the current issue of Nature, they have now decoded a new cellular mechanism for the development of aggregates.

These categories involve cellular processes that occur early in kidney development.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

The research produced another important finding: «We were able to explain the role of iodine in embryonic brain development at the cellular level,» says Denise Stenzel.

The major goals of this project are to determine the combined influences of light and gravity on plant development through the identification of changes in the mechanisms and regulation of essential cellular functions.

The recent development of genetically - encoded fluorescent biosensors specific to glutathione (GSH), the most abundant cellular redox buffer, has facilitated the IGB research group's discovery of distinct alterations of glutathione redox potentials in the cytosol versus mitochondria within the cell.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

The finding is anticipated to help in the search for causes of kidney disease, new drug development, and other cellular research.

He said: «Our study has shown for the first time the evidence that local anaesthetic may affect the development of children's teeth in cellular and molecular levels.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

Traditional hydrogels made up of either synthetic polymers or natural biomolecules often serve as passive scaffolds for molecular or cellular species, which render these materials unable to fully recapitulate the dynamic signaling involved in biological processes, such as cell / tissue development.

The PAF1 complex has many essential diverse roles in controlling cellular processes and organ development in the embryo.

Scientists at the Montreal Neurological Institute and Hospital - The Neuro, McGill University, have made important discoveries about a cellular process that occurs during normal brain development and may play an important role in neurodegenerative diseases.

The new cellular and molecular data uncovered in the current study will be «exploited in the future to further improve liver bud organoids» and «precisely recapitulate differentiation of all cell types» in fetal human development, the authors write.

Scientists from The Scripps Research Institute (TSRI), working closely with researchers at the National Institutes of Health (NIH), have mapped out the structure of an important protein involved in cellular function and nervous system development.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

The precise timing of those cellular activities is critical to normal heart development, with disruptions in the structure of proteins called histones linked to later heart problems..»

It is caused by a mutation in the ACVR1 gene, which over-activates a cellular signaling process that is important for embryo development and involves a protein called BMP.

Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and / or protein modifications with reporter functionalities.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

The Belmonte Laboratory is interested in the cellular and molecular functions of plant development and plant pathogenesis.

One view of the Phylogeny of Life on Earth (at the University of California at Berkeley's Museum of Paleontology) highlights the role of archeabacteria among prokaryotes — as a separate «Archaea domain» apart from Eubacteria — in the development of cellular life with nuclei (eukaryotes).

Selected Fellows will utilize a wide variety of biological systems, approaches and technologies in the study and translation of basic cellular processes involved in the development of cancer.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

I have established research interests in the cellular and molecular mechanisms regulating the development and function of the testes and which influences spermatogenesis.

Over the last decade, I have been dedicating myself to the cellular and molecular background of the observation I made in 2004, that the cephalic neural crest (CNC), exerts an autonomous and prominent control on forebrain development.

The research of the department focuses on the development of cryo - electron tomography which is widely seen now as a method of unique potential for visualizing macromolecular complexes in their functional cellular context.

Toll2018, like the previous five meetings, aims at displaying and challenging most recent developments in cellular innate immunity.

The common characteristic of all types of SCID is absence of T - cell - mediated cellular immunity due to a defect in T - cell development.

He studies the molecular mechanisms by which female steroid hormones such as estrogen control development, differentiation, cellular proliferation and survival in hormone - responsive tissues and cancers.