These findings indicate that protein misfolding and aggregation may play an important role
in cellular dysfunction during aging, opening a novel approach to increase longevity and enhance the quality of life during aging.
They found that the genetic mutation associated with Leigh's disease compromised ATP levels, and this reduction of ATP was enough to cause
significant cellular dysfunction.
Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in
cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].
But chronic inflammation — a danger signal blaring indefinitely — can lead to all manner
of cellular dysfunction, contributing to many degenerative diseases.
ALA acts as a powerful anti-aging substance by combating the two major factors responsible
for cellular dysfunction (and death)-- free radical damage and glycation.
«The therapeutic areas,» Hong said, «are merging at the molecular levels and transforming into metabolic disorders or
cellular dysfunction.»
One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to
cellular dysfunction or cell death.
Experts will discuss topics such as site - specific recombination reactions and
cellular dysfunction, as well as how to utilize cutting - edge technology to discover pathways and specific patterns that impact such factors as the inability of the body to mount an immune response and somatic recombination in antibody production.
But why
the cellular dysfunction occurs decades after exposure is still a puzzle, he adds.
In many degenerative diseases, including neurological, metabolic, genetic, and inflammatory diseases, it's thought that the accumulation of misfolded proteins leads to
cellular dysfunction and death.
Over the course of your lifetime free radical damage tends to accumulate, and scientists theorize that this accumulated damage contributes to
cellular dysfunction and ultimately to declining health as we age, and is thought to be a significant part of the aging process itself.
«If it's later [in life], then they may have
cellular dysfunction.»