Sentences with phrase «cellular effect of»

The hair analysis measures a metabolic or cellular effect of the thyroid hormones upon the metabolic rate.

Lower hair potassium is associated with reduced cellular effects of thyroid hormones.

Park, M. K., Kwon, H. Y., Ahn, W. S., Bae, S., Rhyu, M. R., and Lee, Y. Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf - 7 human breast cancer cells.

Not exact matches

Although the work is done in the context of a more general problem — the effect of environmental electromagnetic fields upon cellular functions — Adey is also concerned with the question of how brain waves might play a role in normal brain function.

PACKED WITH POWERFUL COMPOUNDS - the antioxidants in cacao offer cellular defense against the effects of free radicals, improving the look of skin and promoting cellular repair and rejuvenation.

The antioxidants in cacao offer cellular defense against the effects of free radicals, improving the look of skin and promoting cellular repair and rejuvenation.

One possibility is that they interfere with the beneficial effects of exercise, as there are hints that free radicals might be used by the body to prevent cellular damage after exercise.

The boosted genes had three main effects: improving cellular energy efficiency; upping insulin production, which improves control of blood sugar; and preventing the breakdown of caps on chromosomes that help prevent cells wearing out and ageing.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumors.

It is critical for physicians to monitor these secondary tissue damages, as they are frequently the origin of significant long - term effects, including brain damage, cognitive deficits, psychosocial / behavioral / emotional changes, bodily damage and biochemical changes at the cellular level.

There was little evidence that switching from the cellular to the acellular pertussis vaccine had a significant effect on the spread of pertussis in Massachusetts.

Patricia Garcez examines the cellular and molecular effects of Zika virus congenital syndrome during brain development.

Hackermüller suspects that non-coding RNAs have an important function at the epigenetic level, for example as a type of cellular long - term memory: «This could also explain why the health effects caused by exposure to hazardous environmental substances often do not emerge until years later.»

To date, much of the research on irradiation's effects on the cellular microenvironment has dealt with samples that included cells, obfuscating the irradiation's effect on just the ECM rather than the cell's internal machinery.

The NRC panel, chaired by neurobiologist Charles Stevens of the Salk Institute in La Jolla, California, looked at more than 500 human, animal, and cellular studies on EMFs and found «no conclusive and consistent evidence... that exposures to residential electric and magnetic fields produce cancer, adverse neurobehavioral effects, or reproductive and developmental effects.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

The agency's results showed broad similarities with industry's analyses — some effects on silverside fish and mysid shrimp, but no significant disruption of hormonal systems of animals, at least at the cellular level.

Other factors have no significant influence — even with new low - molecular weight HES solutions, cellular - level toxic effects appear just as likely, once the total mass of HES molecules is taken into account.

Many who study radiation's effects on the cellular level prefer to err on the side of caution.

Ana Soto, professor of cellular biology at Tufts University School of Medicine, and her colleagues were studying the effects of estrogen on a breast cancer cell line.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

In their study, the Geneva researchers were also able to dissect the fine cellular mechanisms involved: Of the three estrogens receptors, only one is mainly involved in this protective effect.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

Two approaches to fat grafting — injection of fat cells versus fat - derived stem cells — have similar effects in reversing the cellular - level signs of aging skin, reports a study in the April issue of Plastic and Reconstructive Surgery ®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Their study suggests that EGCG has high potential as a treatment for rheumatoid arthritis because of how effectively the molecule blocks the effects of the disease without blocking other cellular functions.

«The effects observed in this study may be part of larger PTSD - related accelerated cellular aging process that is manifested in premature health decline,» she said..

The group observed that, at the cellular level, one of the side effects of the diet was an expansion of hair follicle stem cells, leading to increasing hair follicle growth and retention rates.

Animal and cellular studies have found that some phthalates block the effects of testosterone on the body's organs and tissues.

Such effects alone could explain why memory seems to falter with age, without there being any weakening of the molecular and cellular mechanisms of memory itself.

Thus, these results indicate that FOXO3 is an important general mechanism by activating multiple cellular protective functions that the normal liver uses to resist the toxic effects of alcohol.»

Despite much study of attention in the brain, the cellular mechanisms responsible for the effects of attention have remained a mystery... until now.

«Our experiments suggest that mGluR5 amplifies the cellular response to a chemical signal, and that by blocking mGlur5 receptors in inhibitory neurons involved in depression, these new therapies can achieve an antidepressant effect,» says senior author Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience.

In addition, LDD patients had abnormally high concentrations of the CILP protein in their lumbar disks.To see what effect the mutated CILP protein has at the cellular level, the researchers added it to rabbit disk matrix cells grown in a Petri dish.

There were no signs of toxic effects on the eye, either in terms of inflammation / infection or on the cellular level.

Although the metabolic responses observed are consistent with the cellular consequences of osteocalcin exposure in pancreatic β - cells and myoblasts in vitro (27 — 29, 61), the metabolic effects of exercise and WBV may not be dependent on osteocalcin per se.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

While ferrous sulphate had no effect, both ferric citrate and ferric EDTA caused an increase in cellular levels of amphiregulin, a biomarker for cancer.

Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.

The advent of high - throughput technologies to systematically evaluate drug effects across different cellular contexts enables such discoveries.

What we are developing now are a really unique set of tools that are going to allow us to monitor the changes in the retina at the cellular scale over time in the same person; and we think that this is really going to have a transformative effect because it's not only very powerful from the statistical point of view but it really is going to allow us to do experiments that were not possible before.

Writing in the February 23 issue of Nature, the team revealed they had once again used small molecules to effect a near - complete cellular transformation.

Hsieh brings expert knowledge of prostate cancer and the PI3K pathway and its effects on a critical cellular process: translating genetic material into proteins, our cells» workhorses.

The lab's findings in the study, «D - serine Deficiency Attenuates the Behavioral and Cellular Effects Induced by the Hallucinogenic 5 - HT2A Receptor Agonist DOI,» suggested that D - serine - dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5 - HT2AR activation.

Multiple effects of a novel epothilone analog on cellular processes and signaling pathways regulated by Rac1 GTPase in the human breast cancer cells.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

Interference with a host of cellular functions tested and synergistic activities with a wide range of other drugs is best explained by direct interaction with various DNA sequences and general interference with replication and transcription, except for some effects exerted by binding to tubulin.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

A major lab project involves the study of prohormone convertase enzymology and potential dominant negative effects (effects of oligomerization, the role of the inhibitory tail domain, and cellular targeting).