It involves cell degradation of unnecessary or dysfunctional cellular components, which ensures cellular survival during starvation by
maintaining cellular energy levels.
That led Shaw and his team to a class of drugs called biguanides, which
lower cellular energy levels by attacking the power stations of the cell, called mitochondria.
SAN FRANCISCO, CA — A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria — the brain's cellular power plants — can
deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.
Scientific evidence is mounting to support CoQ10 as a powerful tool when used to
improve cellular energy levels and fight the advances of cardiovascular disease.
Another connection is that ALA promotes an increase in AMPk, an enzyme activated as a result of
lower cellular energy levels (higher NAD + / NADH ratio).
In both cases, UDCA improved mitochondrial function as demonstrated by the increase in oxygen consumption and
cellular energy levels.»
One of the earliest events in HD is that mutant huntingtin aggregates disrupt the function of mitochondria, lowering
cellular energy levels and causing oxidative damage.
AMPK (adenosine monophosphate - activated protein kinase) is an enzyme that acts as a metabolic master switch and is activated in response to low
cellular energy levels.
AMPK senses the ADP / ATP ratio, thus knowing
the cellular energy levels — sort of like a fuel gauge but in reverse.
«AMPK detects the AMP / ATP ratio and when this ratio is low (low
cellular energy levels), AMPK is activated» should read «AMPK detects the AMP / ATP ratio and when this ratio is HIGH (low cellular energy levels), AMPK is activated»