Sentences with phrase «cellular functioning in»

Alfredo Dubra, PhD, and his colleagues at the Medical College of Wisconsin, Milwaukee, are applying adaptive optics to study cellular function in order to uncover glaucoma biomarkers.

Analysis of targeted mutation in DJ - 1 on cellular function in primary astrocytes.

Actin dynamics and organisation are tightly regulated processes responsible for the range of different and specific cellular functions in response to various stimuli.

In addition, he is also studying the normal huntingtin cellular function in autophagy and how expansion of the poly - Q repeat may impair this function in HD.

Because psychiatric diseases predominantly affect cellular function in the brain, it can be hard to get a clear picture of exactly what is being affected at the molecular level.

A subclass of ncRNA transcripts are encoded by highly regulated, multi-exon, transcriptional units, are processed like typical protein - coding mRNAs and are increasingly implicated in regulation of many cellular functions in eukaryotes.

When endurance athletes train, they use up the glycogen in their muscles, but when bodybuilders train they use adenosine triphosphate (ATP) which is a whole other fuel source and also a major source of energy for most cellular functions in a human body.

Potassium is a mineral that is necessary for electrical and cellular functions in the body.

According to the National Institute of Health, magnesium is responsible for more than 300 cellular functions in the body.

Modern lifestyles and environments have induced changes in cellular function in unimaginable ways, often to the detriment of the human body.

Not exact matches

Although the work is done in the context of a more general problem — the effect of environmental electromagnetic fields upon cellular functions — Adey is also concerned with the question of how brain waves might play a role in normal brain function.

It contains Hyaluronic Spheres (found naturally in the body) to improve cellular function, prevent dehydration, and fill in lines and wrinkles.

Some autopsy data shows that infants of smokers have signs of established hypoxic - ischemic cellular injury in the brain and the heart which probably occurred in antenatal life, may have been caused by suboptimal placental function and may have been sub-clinical, but if the baby continues to be in a vulnerable environment exposed to post-natal passive smoking, this could affect autonomic nervous system function and lead to poor temperature control, and poor heart rate and respiration control.

Although much of the cellular and sub-cellular functions of the human brain remain unknown, the insights we currently have paint a more nuanced understanding of human nature, which in turn helps shape our understanding of politics, IR theory, and global order.

For it to be useful, cryopreserved ovarian tissue must thaw in a way that maintains its original cellular structure and function.

This junction is important because of the roles it plays in cellular communication, nutrient exchange and absorption, and other skin functions.

The idea is that the mitochondria — cellular energy generators — in young, primitive cells function much better than those in the mature eggs collected for IVF.

The idea is the mitochondria — the cellular energy generators — in these primitive cells function better than those in the eggs of women struggling to conceive.

«Lipids play a vital role in cellular function, because they form the membranes that surround each cell and many of the structures inside of it,» Quinlivan said.

The affected mitochondria could no longer provide the synapses with enough energy, which ultimately prevented the synapses from functioning — providing the first direct link between cellular injury caused by amyloid protein and the characteristic breakdown of neuronal communication that occurs in Alzheimer's patients.

These data demonstrate that in RNA's with very different cellular functions, there are domains with similar structural and functional properties and that there is a nucleotide in M1 RNA that affects the site of cleavage by the enzyme.

The organizers, including researchers from Frankfurt, expect that many cellular functions of membrane lipids will be revisited from a new perspective and that it will be possible to support hormone - producing cells in a more targeted manner.

The most famous is the gene ontology, in which categories are assigned to genes based on their cellular location, molecular function, and biological process.

In both cases, UDCA improved mitochondrial function as demonstrated by the increase in oxygen consumption and cellular energy levels.&raquIn both cases, UDCA improved mitochondrial function as demonstrated by the increase in oxygen consumption and cellular energy levels.&raquin oxygen consumption and cellular energy levels.»

HIF - 1 senses reduced oxygen levels and triggers many changes in cellular function, including a changed metabolism and sending signals for the formation of new blood vessels.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

Although no functions could be assigned to three of the proteins, bioinformatics analysis suggested that the remainder are involved in a wide range of biological processes, including reproduction, cellular metabolic processes, multicellular organismal growth, developmental processes, growth, locomotion, response to stimuli, localization and biological regulation.

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

This enabled the researchers to detect mutations in three genes — GNPTAB, GNPTG, and NAGPA — involved in the function of lysosomes, the cellular sacs where debris gets recycled.

In humans, stuttering has long been linked to a mutation in the «housekeeping» gene Gnptab, which maintains basic levels of cellular functioIn humans, stuttering has long been linked to a mutation in the «housekeeping» gene Gnptab, which maintains basic levels of cellular functioin the «housekeeping» gene Gnptab, which maintains basic levels of cellular function.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

But a string of recent discoveries indicates that a class of RNA molecules called small RNAs are actually in charge of many cellular functions.

They found many of the 131 regions were related to genes involved in growth and development and cellular function and maintenance.

«Our findings indicate that metabolites alone appear to be able drive many of the key changes in cellular function and differentiation,» Ruohola - Baker said.

Recently, researchers have begun to describe the function of autophagy, a cellular recycling process critical for homeostasis, in germline stem - cell proliferation of C. elegans.

Optogenetic methods and tools have evolved fast, and in addition to be able to control cellular activity, researchers can now control the activity of gene function.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

«While more work is required to elucidate the cellular and molecular mechanisms through which B cells exert their beneficial function in wound healing, we are in the process of obtaining the required regulatory approvals to conduct a first clinical study in patients with diabetic foot ulcers.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and more damaging cellular waste.

But these molecules have been difficult to study, and Tavazoie's team wanted to know if changes in the amount of tRNAs can affect cellular function.

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

But Skalak says Allen intends to fund such established scientists» work in «wholly new» areas: Doudna, for example, will explore a new mechanism to edit cellular function by targeting RNA.

Her research is at the interface between bioimaging and proteomics, and aims to define the spatiotemporal organization of the human proteome at a subcellular level in an effort to understand how variations and deviations in localization contribute to cellular function as well as disease.

His pioneering research has focused on defining the cellular and molecular nature of immune exhaustion — the failure of normal immune system function — in chronic infection and cancer.

Professors Marshall - Gradisnik and Don Staines and their research team have identified significant impairments in cellular function of people with CFS.