One of the ten emerging technologies selected was the Human Cell Atlas, which aims to integrate research exploring all the «omes»: the genome (the full set of
genes), the transcriptome (the RNA made from all
genes), the proteome (the proteins), the metabolome (small molecules, such as sugars, fatty acids and amino acids, involved or generated by
cellular processes), and the fluxome (metabolic reactions
whose rates can vary under different conditions).
Now a research team led by Broad Institute Imaging Platform director Anne Carpenter and postdoctoral fellow Mohammad Rohban has shown that a high - throughput, computerized imaging technique for studying morphology, called Cell Painting, can provide insight into the
cellular roles of
genes or disease - linked
gene alleles
whose function or impact is unknown.
In contrast, the most enriched functional categories with
genes whose promoters were more methylated in the CPA group included neurological diseases (encephalopathy),
cellular growth and proliferation (cancer and blood cells) and
gene expression (Table S1).