With respect to biological applications, the group is focusing on
how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).
Current protocols for generating hepatocytes from hESCs are hampered by inefficient differentiation procedures that lead to low yields and
large cellular heterogeneity.
«Such bulk approaches fail to
reveal cellular heterogeneity and the interplay that underlies many pivotal biological functions» says Sten Linnarsson, Platform Director of the Eukaryotic Single - Cell Analysis facility.
They did so by including factors like the mechanical forces acting on the cells and the tumor's
cellular heterogeneity.
This approach will help us define
the cellular heterogeneity within each cancer, an important step towards improving cancer treatment.»
Attempts to obtain global analyses of premalignant gastric material have so far been hampered by minimal yields and
cellular heterogeneity.
This cellular heterogeneity has been thought to reflect mostly the developmental and maturation stages of various normal stem and progenitor cells (1).