Sentences with phrase «cellular hypoxia response»
It was a gene called the von Hippel - Lindau (VHL) factor, which encodes a protein that puts a brake on the cellular hypoxia response.
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In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
The hypoxia inducible factors (HIFs) integrate cellular responses to hypoxia.
Autophagy, a cellular cleaning process, gets activated in response to certain types of metabolic stress, including nutrient deprivation, growth factor depletion and hypoxia.