Sentences with phrase «cellular interactions in»

Once they had achieved this precise control over the cellular interactions in the brain, they turned to exploring behavior: Mice that are less fearful are more likely to venture farther than others.

For example, the researchers are gaining a better understanding of how tweaks to the chemical structure of their test compounds affect the substances» cellular interactions in the body.

Not exact matches

In a new study researchers have investigated the associations between office type (cellular office, shared - room office, small open - plan office, and medium - sized open - plan office) and employees» job satisfaction, well - being, and ease of interaction with co-workers.

Although blood cells serve multiple roles in the body and have complex interactions with other cellular materials, most synthetic blood products have aimed to just stick to the bare basics — shuttling oxygen from the lungs to different vital organs and then bringing carbon dioxide back to the lungs to be exhaled.

Necessity Is the Mother of Invention: SciJobs.org As a graduate student, Plautz used cellular and molecular biology techniques to examine the interactions that lead to lens and eye formation in vertebrates such as frogs.

This interaction activates MALT1 to cleave and inactivate a number of cellular proteins that normally keep the immune system in check.

AgriLife Research scientists in Lubbock began searching the fields and plants for answers to help farmers cope, while another team in College Station took a deep look at the bacterium and cotton interaction at the cellular level and discovered its covert operations.

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

Lüpold says that such interactions underlie the coevolution of sperm - female tract traits observed in numerous taxa: «Giant sperm tails represent the cellular, postcopulatory equivalent of peacock tails, having evolved mainly through female sperm choice.»

«Our study on the TACC3 - chTOG interaction will allow cellular biologists and researchers on microtubule dynamics to better understand how microtubule assembly is regulated during cellular division,» says Montoya, and he anticipates that «it could also help in developing new anti-microtubule drugs, providing more effective therapeutic options in cancer treatment.»

As nanomedicine advances from passive technologies, in which nanoparticles act as vehicles for drugs, to active treatments that involve more complex cellular interactions, specialized oversight may become ever more necessary, says Roco.

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

«When we study the interactions between the host cell and the virus, we get information about both of them and about how cellular machinery is working under viral infection,» says Alessia Ruggieri, a group leader and virologist at University of Heidelberg in Germany and senior researcher on the study.

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

Proteins are responsible for the vast majority of the cellular functions that shape life, but like guests at a crowded dinner party, they interact transiently and in complex networks, making it difficult to determine which specific interactions are most important.

Researchers are building a substantial understanding of the biophysical, molecular, and cellular interactions of neurons, but directly relating those interactions to outward behaviors is an ongoing challenge in the field.

Through a variety of mechanistic interactions, mTORC1 interprets cues in the cellular environment, including the availability of nutrients, and signals the organism to act accordingly.

The goal is to not only provide broadly applicable experimental tools but also help transform the way in which we think about single cells, cell - cell interactions, diseased cellular states and therapeutics so as to create a new paradigm for understanding and designing systems - level cellular behaviors in multicellular organisms.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

This is in part due to the complexity of host - virus interactions leading to cellular transformation.

Research in our laboratory focuses on the cellular and molecular mechanisms of action of substances of abuse and their interaction with neurotransmitter systems.

The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.

From a functional perspective, «interaction» can mean anything from direct physical binding to indirect functional association such as participation in the same metabolic pathway or cellular process.

The quantitative analysis of molecule interactions in bioimaging is key for understanding the molecular orchestration of cellular processes and is generally achieved through the study of the spatial colocalization between different populations of molecules.

«Cell - nanoparticle interactions can produce significant change in cellular behaviour that we can observe using this technique,» explains Irtisha Singh, who is one of the senior authors of this study.

SAN DIEGO — January 9, 2014 Researchers from the La Jolla Institute for Allergy and Immunology have revealed a critical player in the cellular interactions leading to eczema — a chronic inflammatory skin condition affecting more than 14 million U.S. children and adults.

According to a release from Dr. Hassan Dihazi, editor in chief, the journal covers all areas of proteomics including basic proteomic research; structural, functional, property, and interaction analysis of cellular systems, organelles, and protein complexes; and protein expression profiling for the discovery and validation of diagnostic and prognostic disease biomarkers.

Being able to isolate, manipulate and image single & multiple cells in their natural environments is vital to researchers in many fields, notably those involved in drug discovery, early stage diagnosis and cellular force interactions making the addition of FluidFM ® to the world of AFM imaging and force spectroscopy an ideal pairing.

«Given the importance of stem cell - based transplantation therapies as well as the clinical significance of tumor metastastis to the bone marrow, there is great therapeutic potential in understanding these cellular interactions,» Sipkins said.

Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and age - related neurodegenerative diseases.

In the latest issue of Neuronal Signaling, Tata and Ruhrberg discuss cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels.

Our strong expertise allows us study lipid - protein interaction based phenomena at different scales, from the organ and cellular systems down to minimal synthetic systems in which we can control the proteins as well as the lipid, for instance to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor (Coskun et al (2011) PNAS) and the insulin receptor.

In addition, a fluorescent microscope was used to examine host - pathogen interaction on a cellular level.

Therefore, key challenges for biology in the twenty - first century are the exploration of the structure and the dynamics of this complex inter - and intra - cellular web of interactions that contribute to the structure and function of a living cell.

This is the only way one can accurately mimic the myriad cellular interactions that might play a role in causing the disease phenotype.»

An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.

The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors.

In the study, the researchers describe the microscopic physical interactions and chemical changes of proteins associated with several cellular functions, including disease forms, and how still - healthy cells could try to temper it.

In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanismIn conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanismin complex diseases and provides insights into the underlying cellular and molecular mechanisms.

Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA - protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour of cells in tissues and organisms (wound healing, morphogenesis).

In addition to their antioxidant properties, these polyphenolic compounds exhibit neuroprotective properties by their interaction with cellular signaling pathways followed by transcription and translation that mediate cell function under both normal and pathologic conditions.

Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site - specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure.

Humanity is not «heated by Energy in the surface incident UV Spectrum, the cells of the bio-form are infact directly damaged by these «Photons» in interaction with the molecules constituting that cellular structure.

In contrast, with Gondwana centred over the South Pole, climate in the Southern Hemisphere must have been dominated by the interaction of cellular air masses over land and wateIn contrast, with Gondwana centred over the South Pole, climate in the Southern Hemisphere must have been dominated by the interaction of cellular air masses over land and watein the Southern Hemisphere must have been dominated by the interaction of cellular air masses over land and water.