They also found that TRIM25 (previously believed to be present only in the cell cytoplasm) is also present in the cell nucleus, which is the
same cellular location where flu replication occurs.
It is likely that asymmetries in the friction between proteins and these biopolymers will prove to be important in guiding them to the
correct cellular locations.»
In certain cancers, low - complexity domains are improperly attached to other proteins that may then incorrectly form droplets
in cellular locations, leading to mis - regulated expression of genes, Fawzi said.
The most famous is the gene ontology, in which categories are assigned to genes based on
their cellular location, molecular function, and biological process.
As scientists began to sequence human genes in the 1990s, sorting out
the cellular locations of each gene's proteins became a priority, says Mathias Uhlén, a microbiologist at the Royal Institute of Technology in Stockholm, Sweden, and director of the Protein Atlas effort.
Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and
their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.
Using high - tech robots and old - fashioned hard labor, Howard Hughes Medical Institute researchers have measured the abundance and pinpointed
the cellular locations of more than 4,000 proteins in yeast...