Sentences with phrase «cellular mechanism of the cancer»

In addition, her lab is evaluating ways to target anti-cancer medications more specifically to the cancer cell by targeting the cellular mechanism of the cancer.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

Not exact matches

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

«We reasoned that if we could identify microRNAs that regulate the progression of colorectal cancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer Bicancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer BiCancer Biology.

To gain an understanding of the mechanism that connects low mtDNA levels with a cellular change that leads to cancer and metastasis, Guha, Avadhani and their colleagues set up two systems by which they could purposefully reduce the amount of mtDNA in a cell.

«Our research reveals a new regulatory mechanism that coordinates two distinct intracellular processes that are critical to cellular homeostasis and disease development,» said Chengyu Liang, M.D., Ph.D., a member of the USC Norris Comprehensive Cancer Center and principal investigator of the study.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

Sabatini and Yilmaz, whose labs study the relationship between diet and cancer, set out to uncover the cellular mechanisms underpinning the enhanced risk of colon cancer.

She is currently studying the cellular and genetic mechanisms of liver cancer with the hope of identifying new biomarkers and drug targets for this often fatal disease.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

Our ultimate goals in this activity include (1) a better understanding of the molecular mechanisms governing cellular processes and especially those involved in certain kinds of diseases such as cancer and (2) the development of computational tools that can be used for diagnostic / prognostic purposes based on genomic data.

She continued to develop these models and to investigate the molecular and cellular mechanisms underlying human tumor dormancy as an instructor in Folkman's lab and later as an Assistant Professor at the Center of Cancer Systems Biology at Tufts University School of Medicine, Boston.

Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.

Our team is using a combination of cutting - edge proteomics, molecular and cellular biology strategies to uncover new alt - EJ players and decipher their mechanisms of action in cancer.

This understanding of the cellular and molecular mechanism of recovery from acute promyelocytic leukaemia opens prospects for activating this same PML / p53 pathway in other types of cancers.

His laboratory focuses on the cellular and molecular mechanisms of cancer progression.

The major two focuses of his Ph.D. study were to study the cellular and molecular mechanisms of prostate cancer metastasis and to study the effects of pomegranate derived natural products on prostate and breast cancer progression.

Genotype - driven early phase trials, including exceptional responders and mechanisms of resistance and immune mechanisms in cancer and cellular therapy.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.

Cancer hijacks the immune system by various cellular and molecular mechanisms and dysfunction of immune system arises during the early stages of cancer and throughout progression to later aggressive sCancer hijacks the immune system by various cellular and molecular mechanisms and dysfunction of immune system arises during the early stages of cancer and throughout progression to later aggressive scancer and throughout progression to later aggressive stages.

Research out of the University of Cambridge has verified the link between toxic chemicals called aldehydes, the destruction of DNA repair mechanisms and a higher risk of cancer due to their effects at the cellular level.

A very recent study on the effects of fasting and calorie restriction on cancer patients receiving chemotherapy found that calorie restriction and fasting seem to trigger a protective cellular mechanism so strong, that it would be difficult to achieve such an effect with potent drug intervention.

Because the pathophysiology of cancer is linked to alteration of cellular gene expression, the bioinformatics toolbox promises to offer countless molecular insights into mechanisms, diagnostics, and new medical interventions for cancer.

Faculty research interests and expertise include mechanisms of metastasis in cancer; gene therapy (including electroporation) in cancer; cell and molecular biology of tooth eruption; pharmacology and toxicology of aquatic species; environmental and ecological toxicology; cellular ultrastructure; environmental risk assessment; analytical pharmacology and toxicology; diagnostic neurophysiology; pharmacology of pain and inflammation; exercise physiology; xenobiotic metabolism and disposition; neurochemistry; pulmonary pharmacology; cardiovascular disease; and cetacean morphology.