Sentences with phrase «cellular mechanisms at»

The prize, considered among the most prestigious in the scientific community, recognizes Schreiber for his work in chemical biology and for the use of small molecules as probes to uncover novel cellular mechanisms at the root of human health and disease.

«Our findings both validate and prompt further use of this first - in - kind fly model of kidney cyst formation in order to pinpoint the molecular and cellular mechanisms at work,» says Gamberi.

Not exact matches

Cédric Blanpain, MD / PhD, WELBIO investigator, and Professor at the Université libre de Bruxelles, Belgium, defined the cellular and molecular mechanisms that regulate wound healing in the skin.

«While rodents are essential for understanding mechanisms at a cellular or molecular level, at a higher cognitive level, the best you could do was a sort of rough analogy.

«We are trying to understand the causes of aging by linking the mechanisms that control the oxidation of proteins at the cellular level with the mechanisms that determine the lifespan of the whole organism,» Apfeld says.

Today is the 70th birthday of Elizabeth Hay, an embryologist at Harvard Medical School who, through pioneering studies on regeneration of amphibian limbs, has shed light on the cellular mechanisms that transform normal cells into tumors.

This LTP mechanism is how the brain operates at the cellular level to allow us to learn and remember.

Now, scientists at Princeton have used «designer chromatin'templates — highly customized replicas of cellular DNA and histone proteins, the scaffolding proteins around which DNA is wrapped — to reveal new details about Suv39h1's mechanism.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

In fact, the Mitalipov group found that cellular repair mechanisms, at least in their experiments, did not respond very well to the introduction of a synthetic repair template added by the researchers.

But in the study being published, researchers at the Department of Cell and Molecular Biology at Karolinska Institutet present a molecular time mechanism that can help explain neuronal stem cell regulation and therefore also the occurrence of cellular diversity in the brain.

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

Researchers at Aarhus University, Denmark, have succeeded in identifying the mechanisms involved in what is known as the acid pump, which at the cellular level pumps acid into the stomach — in some cases leading to gastric ulcers and gastroesophageal reflux disease.

«We have already demonstrated that these two synapses process different types of information that in turn is likely to comprise the cellular mechanisms for memory encoding and retrieval at these synapses» explains Hardy Hagena.

As researchers at the Max Planck Institute of Biochemistry report in the current issue of Nature, they have now decoded a new cellular mechanism for the development of aggregates.

Understanding mechanisms of vocal learning at a cellular level is a huge step toward being able to someday address the biological issues behind the behavioral issues,» said Sarah Bottjer, senior author of an article on the research that appears in the Journal of Neuroscience on Sept. 4.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

The mechanisms underlying consciousness could reside at any of a variety of physical levels: molecular, cellular, circuit, pathway, or some organizational level not yet described.

A previous study by Segev at the laboratory for research of molecular and cellular mechanisms, directed by Prof. Kobi Rosenblum in the Sagol Department of Neurobiology at the University of Haifa, found a connection between a genetic condition known to be a risk factor for sporadic Alzheimer's and premature aging as manifested in ongoing metabolic stress.

This mechanism helps «clean up» cellular debris at the synapse, by engulfing the debris in a membrane and then removing it, for instance.

For instance, this device can help us understand the mechanisms by which various inputs and treatments alter plant growth at the cellular level.

Researchers from the Institute of Neuroscience at the Universitat Autònoma de Barcelona have discovered the cellular mechanism involved in memory consolidation and were able to develop a gene therapy which reverses the loss of memory in mice models with initial stages of Alzheimer's disease.

The body's own cellular and humoral mechanisms are usually still operating at some level.

He and his colleagues at the University of Wisconsin — Madison have begun to explore how fruit flies could help uncover the cellular mechanisms behind traumatic brain injury (TBI) in humans.

Research at CNIC is aimed at identifying the cellular and molecular mechanisms underlying the origin and evolution of cardiovascular illnesses.

«Our study shows that the ability of malaria parasites to engage red blood cells is driven by an ancient mechanism for cellular attachment,» said lead author Aditya Paul, a postdoctoral researcher at the Harvard Chan School.

Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.

Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly.

P16: P16 is perhaps best known as an indicator of cellular senescence, a part of the mechanisms that cause damaged cells or those at the Hayflick limit to become senescent or self - destruct.

At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the molecular and cellular mechanisms through which experience alters the structure and function of neural circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

Yusuke did his graduate work in Dr Yukiko Gotoh lab at University of Tokyo and joined the Polleux lab in 2013 where he studies the molecular and cellular mechanisms underlying presynaptic capture of mitochondria.

The major portion of our research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the (ER).

She continued to develop these models and to investigate the molecular and cellular mechanisms underlying human tumor dormancy as an instructor in Folkman's lab and later as an Assistant Professor at the Center of Cancer Systems Biology at Tufts University School of Medicine, Boston.

My research interest is to understand the neuroendocrine mechanisms that regulate reproductive function and behaviors at molecular, cellular, and systemic levels.

Modern biophysics is a broad and rapidly advancing field encompassing the study of biological structures with a focus on mechanisms at the molecular, cellular, and systems level using the concepts and methods of physics, chemistry, mathematics, engineering, and computational science.

Most of the discussion section at the end of the paper focuses on the complexity of the molecular and cellular mechanisms involved with vascular injury, especially in very advanced lesions.

Plenary Address: Alcino Silva Departments of Neurobiology and Psychology, and the Brain Research Institute, University of California at Los Angeles, USA Molecular and cellular cognition: from memory mechanisms to treatments

Writing in the June 9 online edition of Nature Genetics, the scientists reveal a cellular signaling mechanism in place at the earliest developmental stage.

Now, a research team headed by investigators from the Icahn School of Medicine at Mount Sinai is the first to identify a mechanism by which influenza A, a family of pathogens that includes the most deadly strains of flu worldwide, hijacks cellular machinery to replicate.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

We are currently dissecting the molecular mechanisms used at the cellular and tissue - wide level to dampen the deleterious effects of CIN in the wing epithelium.

This includes proposals that address mechanisms of memory or cognition at the synaptic, cellular, molecular, genetic or behavioral level in animals, including humans.

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

Our group focuses on this question and uses the cnidarian Nematostella vectensis as a model organism to study how such morphological plasticity mechanisms are encoded at the molecular and cellular level.

The Flow Cytometry and Cell Imaging Core Facility in the Department of Epigenetics and Molecular Carcinogenesis at Science Park provides cutting - edge resources to dissect the cellular and molecular mechanisms of developmental and disease processes.

Research out of the University of Cambridge has verified the link between toxic chemicals called aldehydes, the destruction of DNA repair mechanisms and a higher risk of cancer due to their effects at the cellular level.

NASA recently accepted a research proposal to study this topic further, but Dr. David Zawieja, the author of the study and the director of the Division of Lymphatic Biology at Texas A&M, admits the cellular mechanisms regulating the lymphatic contractions are still unknown.

A just - published new study pulls back the curtain to show how quercetin operates at a cellular level to foil cancer - promoting mechanisms in the body.

In fact, it has a lot to do with what we don't ingest This is because cellular cleansing often comes about when we give our bodies a rest from regular meals, which helps our bodies use their built - in mechanisms to cleanse themselves at the cellular level.