Sentences with phrase «cellular mechanisms by»

What are the molecular and cellular mechanisms by which patients with certain chronic diseases have increased or decreased risks for developing cancer, and can these connections be exploited to develop novel preventive or therapeutic strategies?

Future studies should elucidate the molecular and cellular mechanisms by which regional environment controls phenotypic variations of neuronal types.

In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

They revealed that many of these exosomes contained ephrins and Ephs, and decoded the cellular mechanism by which they were packed into the exosomes.

University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety.

«It's critical to understand the cellular mechanism by which the liver renews itself.

Not exact matches

It seems redundant that the perplexities of molecular mechanisms are made via a cellular blueprint followed in conjunctions of and by intelligent designers all living amid and within each and every molecular mechanisms while the base roots residencies of such super small yet very intelligent beings could very well be each and every cell's DNA.

Analysis of endogenous small RNAs indicated that a fraction derive from a biosynthetic mechanism that is similar to that of secondary siRNAs formed during RNAi, suggesting that small antisense transcripts derived from cellular messenger RNAs by RdRP activity may have key roles in cellular regulation.

A research team from iMM Lisboa led by Luís Graça has found a cellular mechanism that underlies the development of autoimmune diseases.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

«We are trying to understand the causes of aging by linking the mechanisms that control the oxidation of proteins at the cellular level with the mechanisms that determine the lifespan of the whole organism,» Apfeld says.

Valproic acid is widely used to treat various types of seizure disorders, but to this point, the cellular mechanism affected by its anticonvulsant properties were not well understood.

The more primitive virus, however, carries no repair mechanisms; a new virion (complete virus) acquires lipids for its envelope by literally ripping them off of the cellular membrane as it buds off from the infected cell.

The Loyola study is titled, «Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.»

«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.

In this case, he was testing the idea that a buildup of cellular damage caused by oxidation — technically, the chemical removal of electrons from a molecule by highly reactive compounds, such as free radicals — is the main mechanism behind aging.

In fact, the Mitalipov group found that cellular repair mechanisms, at least in their experiments, did not respond very well to the introduction of a synthetic repair template added by the researchers.

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

«First aid kit in some living organisms helps fix DNA after lengthy sun exposure: New study unveils the binding mechanisms of enzymes capable of repairing DNA damaged by UV light before any risk of cellular malfunction sets in.»

But Skalak says Allen intends to fund such established scientists» work in «wholly new» areas: Doudna, for example, will explore a new mechanism to edit cellular function by targeting RNA.

This work highlights the importance of appropriate statistical analyses of the large quantitative data sets that are increasingly being produced by experimentalists and are being used to study fundamental cellular mechanisms.

A previous study by Segev at the laboratory for research of molecular and cellular mechanisms, directed by Prof. Kobi Rosenblum in the Sagol Department of Neurobiology at the University of Haifa, found a connection between a genetic condition known to be a risk factor for sporadic Alzheimer's and premature aging as manifested in ongoing metabolic stress.

This mechanism helps «clean up» cellular debris at the synapse, by engulfing the debris in a membrane and then removing it, for instance.

Look up «lysogenic virus» and you read: «a special type of virus bacterial cell interaction maintained by a complex cellular regulatory mechanism».

For instance, this device can help us understand the mechanisms by which various inputs and treatments alter plant growth at the cellular level.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

To gain an understanding of the mechanism that connects low mtDNA levels with a cellular change that leads to cancer and metastasis, Guha, Avadhani and their colleagues set up two systems by which they could purposefully reduce the amount of mtDNA in a cell.

«Our study shows that the ability of malaria parasites to engage red blood cells is driven by an ancient mechanism for cellular attachment,» said lead author Aditya Paul, a postdoctoral researcher at the Harvard Chan School.

Thus, these results indicate that FOXO3 is an important general mechanism by activating multiple cellular protective functions that the normal liver uses to resist the toxic effects of alcohol.»

A University of Rochester team found a way to make chemotherapy more effective, by stopping a cellular quality - control mechanism, according to a study published in Nature Communications.

To avoid detrimental outcome for the organism, cells with mutations that generate deviations from normal chromosomal number are eliminated by cellular protection mechanisms.

Researchers from the Institut Pasteur, CNRS and Inserm, in collaboration with a team from Switzerland, have discovered a previously unknown mechanism by which L. pneumophila targets mitochondria to modulate mitochondrial dynamics and thereby impairs mitochondrial respiration which in turn leads to a change in the cellular metabolism.

The research, taken together, suggests a cellular - level mechanism to back up a 2013 study that concluded children born to mothers whose choline intake was well below the recommendation have lower academic outcomes by age seven.

A team of scientists led by Gladstone's Dr. Steven Finkbeiner have identified a cellular mechanism that can be targeted to treat amyotrophic lateral sclerosis (ALS).

Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes.

In addition, her lab is evaluating ways to target anti-cancer medications more specifically to the cancer cell by targeting the cellular mechanism of the cancer.

Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease.

Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron - related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients» biological samples.

Dr. Tarazi studies the behavioral, genetic, molecular, and cellular mechanisms that mediate the actions of dissimilar psychotropic drugs by using animal models that mimic the core symptoms of different neuropsychiatric diseases.

He studies the molecular mechanisms by which female steroid hormones such as estrogen control development, differentiation, cellular proliferation and survival in hormone - responsive tissues and cancers.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

This includes cellular mechanisms such as photosynthesis and transpiration, and how plant processes are affected by environmental factors or natural variations.

Royet will present his latest data dissecting the cellular and molecular mechanisms by which one single microbiota - derived compound, peptidoglycan, influences the behavior, the physiology, and the homeostasis of its infected host.

The Dotiwala laboratory uses cellular, molecular, biochemical and omics approaches, as well as sophisticated in vivo imaging, to dissect the mechanism by which cell - based immunity (neutrophils, macrophages and killer lymphocytes) is activated in the presence of different pathogenic bacteria, such as intra - and extracellular bacteria, fungi and protozoa.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

She also investigates the cellular and molecular mechanisms of innate and adaptive immune responses by RNA vaccines.

By uncovering the precise cellular mechanisms of nicotine's effect, this study suggests new and more precise targets for drugs designed to block this powerful craving.

The IFN system is a major mechanism by which many viruses evade the cellular antiviral response.

Now, a research team headed by investigators from the Icahn School of Medicine at Mount Sinai is the first to identify a mechanism by which influenza A, a family of pathogens that includes the most deadly strains of flu worldwide, hijacks cellular machinery to replicate.